Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits

Recent data suggests that the glutamatergic system is involved in the pathophysiology and treatment of major depressive disorder (MDD) and that the N-methyl-d-aspartate (NMDA) receptor is a potential target for antidepressant drugs. The magnesium ion blocks the ion channel of the NMDA receptor and p...

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Bibliographic Details
Published in:	The international journal of neuropsychopharmacology Vol. 17; no. 3; pp. 393 - 405
Main Authors:	Pochwat, Bartłomiej, Szewczyk, Bernadeta, Sowa-Kucma, Magdalena, Siwek, Agata, Doboszewska, Urszula, Piekoszewski, Wojciech, Gruca, Piotr, Papp, Mariusz, Nowak, Gabriel
Format:	Journal Article
Language:	English
Published:	Cambridge, UK Cambridge University Press 01.03.2014 Oxford University Press
Subjects:	Analysis of Variance Animals Antidepressants Antidepressive Agents - blood Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Brain - drug effects Brain - metabolism Chronic Disease Disease Models, Animal Disks Large Homolog 4 Protein Dose-Response Relationship, Drug Gene Expression Regulation - drug effects Intracellular Signaling Peptides and Proteins - metabolism Magnesium - blood Magnesium - pharmacology Magnesium - therapeutic use Male Membrane Proteins - metabolism Protein Subunits - metabolism Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - metabolism Stress, Psychological - blood Stress, Psychological - drug therapy Stress, Psychological - pathology NMDA Chronic mild stress magnesium depression glutamatergic system
ISSN:	1461-1457, 1469-5111, 1469-5111
Online Access:	Get full text
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