Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study

Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxi...

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Bibliographic Details
Published in:	The lancet oncology Vol. 13; no. 1; pp. 65 - 77
Main Authors:	Barnett, Gillian C, Coles, Charlotte E, Elliott, Rebecca M, Baynes, Caroline, Luccarini, Craig, Conroy, Don, Wilkinson, Jennifer S, Tyrer, Jonathan, Misra, Vivek, Platte, Radka, Gulliford, Sarah L, Sydes, Matthew R, Hall, Emma, Bentzen, Søren M, Dearnaley, David P, Burnet, Neil G, Pharoah, Paul DP, Dunning, Alison M, West, Catharine ML
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 2012 Elsevier Limited
Subjects:	Androgens Biomedical research Breast cancer Breast Neoplasms - genetics Breast Neoplasms - radiotherapy Cancer research Cancer therapies DNA damage Dose Fractionation, Radiation Dose-Response Relationship, Radiation Female Gene Frequency Genes Genetic Predisposition to Disease Genomics Hematology, Oncology and Palliative Medicine Humans Hypotheses Linear Models Male Medical research Odds Ratio Polymorphism, Single Nucleotide Prospective Studies Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - radiotherapy Radiation Injuries - genetics Radiation Injuries - pathology Radiation therapy Radiotherapy, Adjuvant - adverse effects Radiotherapy, Intensity-Modulated - adverse effects Recruitment Risk Assessment Risk Factors Surgery Time Factors Toxicity United Kingdom United Kingdom > UK British Isles British Isles, England, Cambridge British Isles, England, Greater Manchester, Manchester
ISSN:	1470-2045, 1474-5488, 1474-5488
Online Access:	Get full text
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