IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset

Background Multifocal motor neuropathy (MMN) is a rare, chronic immune-mediated polyneuropathy characterized by asymmetric distal limb weakness. An important feature of MMN is the presence of IgM antibodies against gangliosides, in particular GM1 and less often GM2. Antibodies against GM1 bind to mo...

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Bibliographic Details
Published in:	Journal of neuroinflammation Vol. 21; no. 1; pp. 100 - 14
Main Authors:	Budding, Kevin, Bos, Jeroen W., Dijkxhoorn, Kim, de Zeeuw, Elisabeth, Bloemenkamp, Lauri M., Zekveld, Eva M., Groen, Ewout J.N., Jacobs, Bart C., Huizinga, Ruth, Goedee, H. Stephan, Cats, Elisabeth A., Leusen, Jeanette H.W., van den Berg, Leonard H., Hack, C. Erik, van der Pol, W. Ludo
Format:	Journal Article
Language:	English
Published:	London BioMed Central 17.04.2024 BioMed Central Ltd BMC
Subjects:	Analysis Anti-ganglioside antibodies Antibodies Biomedical and Life Sciences Biomedicine Complement IgM anti-GM2 Immunology Multifocal motor neuropathy Neurobiology Neurology Neurosciences Puncture Schwann cells Spine Testing Viral antibodies Netherlands Multifocal motor neuropathy Complement Anti-ganglioside antibodies IgM anti-GM2 Schwann cells
ISSN:	1742-2094, 1742-2094
Online Access:	Get full text
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