The ‘Digital Twin’ to enable the vision of precision cardiology

Abstract Providing therapies tailored to each patient is the vision of precision medicine, enabled by the increasing ability to capture extensive data about individual patients. In this position paper, we argue that the second enabling pillar towards this vision is the increasing power of computers...

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Published in:European heart journal Vol. 41; no. 48; pp. 4556 - 4564
Main Authors: Corral-Acero, Jorge, Margara, Francesca, Marciniak, Maciej, Rodero, Cristobal, Loncaric, Filip, Feng, Yingjing, Gilbert, Andrew, Fernandes, Joao F, Bukhari, Hassaan A, Wajdan, Ali, Martinez, Manuel Villegas, Santos, Mariana Sousa, Shamohammdi, Mehrdad, Luo, Hongxing, Westphal, Philip, Leeson, Paul, DiAchille, Paolo, Gurev, Viatcheslav, Mayr, Manuel, Geris, Liesbet, Pathmanathan, Pras, Morrison, Tina, Cornelussen, Richard, Prinzen, Frits, Delhaas, Tammo, Doltra, Ada, Sitges, Marta, Vigmond, Edward J, Zacur, Ernesto, Grau, Vicente, Rodriguez, Blanca, Remme, Espen W, Niederer, Steven, Mortier, Peter, McLeod, Kristin, Potse, Mark, Pueyo, Esther, Bueno-Orovio, Alfonso, Lamata, Pablo
Format: Journal Article
Language:English
Published: England Oxford University Press 21.12.2020
Subjects:
Algorithms
Artificial Intelligence
Cardiology
Humans
Precision Medicine
Precision medicine
Digital twin
Artificial intelligence
Computational modelling
ISSN:0195-668X, 1522-9645, 1522-9645
Online Access:Get full text
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Summary:Abstract Providing therapies tailored to each patient is the vision of precision medicine, enabled by the increasing ability to capture extensive data about individual patients. In this position paper, we argue that the second enabling pillar towards this vision is the increasing power of computers and algorithms to learn, reason, and build the ‘digital twin’ of a patient. Computational models are boosting the capacity to draw diagnosis and prognosis, and future treatments will be tailored not only to current health status and data, but also to an accurate projection of the pathways to restore health by model predictions. The early steps of the digital twin in the area of cardiovascular medicine are reviewed in this article, together with a discussion of the challenges and opportunities ahead. We emphasize the synergies between mechanistic and statistical models in accelerating cardiovascular research and enabling the vision of precision medicine.
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ISSN:0195-668X
1522-9645
1522-9645
DOI:10.1093/eurheartj/ehaa159