High-throughput DNA melt measurements enable improved models of DNA folding thermodynamics

DNA folding thermodynamics are central to many biological processes and biotechnological applications involving base-pairing. Current methods for predicting stability from DNA sequence use nearest-neighbor models that struggle to accurately capture the diverse sequence dependence of secondary struct...

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Veröffentlicht in:	Nature communications Jg. 16; H. 1; S. 5572 - 19
Hauptverfasser:	Ke, Yuxi, Sharma, Eesha, Wayment-Steele, Hannah K., Becker, Winston R., Ho, Anthony, Marklund, Emil, Greenleaf, William J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.07.2025 Nature Publishing Group Nature Portfolio
Schlagworte:	45 45/47 45/56 45/77 49 49/23 631/114/1305 631/1647/2163 631/45/147 631/45/535 631/57/2272/951 64 Accuracy Base Pairing Binding sites Biological activity Biotechnology Deoxyribonucleic acid Design DNA DNA - chemistry DNA - genetics DNA probes Folding Graph neural networks High-Throughput Nucleotide Sequencing - methods Humanities and Social Sciences Hybridization Mathematical models multidisciplinary Nearest-neighbor Neural networks Neural Networks, Computer Nucleic Acid Conformation Nucleic Acid Denaturation Nucleotide sequence Science Science (multidisciplinary) Stability Temperature Thermodynamics
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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