A work group report on ultrafine particles (American Academy of Allergy, Asthma & Immunology): Why ambient ultrafine and engineered nanoparticles should receive special attention for possible adverse health outcomes in human subjects

Ultrafine particles (UFPs) are airborne particulates of less than 100 nm in aerodynamic diameter. Examples of UFPs are diesel exhaust particles, products of cooking, heating, and wood burning in indoor environments, and, more recently, products generated through the use of nanotechnology. Studies ha...

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Veröffentlicht in:	Journal of allergy and clinical immunology Jg. 138; H. 2; S. 386 - 396
Hauptverfasser:	Li, Ning, Georas, Steve, Alexis, Neil, Fritz, Patricia, Xia, Tian, Williams, Marc A., Horner, Elliott, Nel, Andre
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.08.2016 Elsevier Limited
Schlagworte:	Air Pollutants Air Pollution allergic inflammation Allergy and Immunology Ambient ultrafine particles Animals Asthma Atoms & subatomic particles Composite materials Cosmetics Disease Susceptibility effect on human health Emissions engineered nanoparticles Environmental Exposure - adverse effects Human subjects Humans Inflammation - etiology Inflammation - metabolism lung inflammation Nanomaterials Nanoparticles - adverse effects Nanotechnology Organic chemicals Oxidative Stress particle deposition and distribution Particulate Matter - adverse effects Public Health Surveillance Roads & highways Silicones - adverse effects Skin Traffic flow allergic inflammation particle deposition and distribution ENM CNT asthma engineered nanoparticles OC PAH AgNP PM2.5 ROS effect on human health PM10 MWCNT ZnO OVA Ambient ultrafine particles oxidative stress EC UFP lung inflammation DC TiO2 Organic carbon Particulate matter with an aerodynamic diameter of less than 2.5 μm Reactive oxygen species Particulate matter with an aerodynamic diameter of less than 10 μm Polycyclic aromatic hydrocarbon PM 2.5 Ultrafine particle Multiwall carbon nanotube Silver nanoparticle Engineered nanomaterial Elemental carbon Zinc oxide Titanium dioxide Dendritic cell Ovalbumin PM 10 Carbon nanotube TiO 2
ISSN:	0091-6749, 1097-6825, 1097-6825
Online-Zugang:	Volltext
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Zusammenfassung:	Ultrafine particles (UFPs) are airborne particulates of less than 100 nm in aerodynamic diameter. Examples of UFPs are diesel exhaust particles, products of cooking, heating, and wood burning in indoor environments, and, more recently, products generated through the use of nanotechnology. Studies have shown that ambient UFPs have detrimental effects on both the cardiovascular and respiratory systems, including a higher incidence of atherosclerosis and exacerbation rate of asthma. UFPs have been found to alter in vitro and in vivo responses of the immune system to allergens and can also play a role in allergen sensitization. The inflammatory properties of UFPs can be mediated by a number of different mechanisms, including the ability to produce reactive oxygen species, leading to the generation of proinflammatory cytokines and airway inflammation. In addition, because of their small size, UFPs also have unique distribution characteristics in the respiratory tree and circulation and might be able to alter cellular function in ways that circumvent normal signaling pathways. Additionally, UFPs can penetrate intracellularly and potentially cause DNA damage. The recent advances in nanotechnology, although opening up new opportunities for the advancement of technology and medicine, could also lead to unforeseen adverse health effects in exposed human subjects. Further research is needed to clarify the safety of nanoscale particles, as well as the elucidation of the possible beneficial use of these particulates to treat disease. [Display omitted]
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0091-6749 1097-6825 1097-6825
DOI:	10.1016/j.jaci.2016.02.023