A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors

The natural compound Artemisinin is the most widely used antimalarial drug worldwide. Based on its cytotoxicity, it is also used for anticancer therapy. Artemisinin and its derivates are endoperoxides that damage proteins in eukaryotic cells; their definite mechanism of action and host cell targets,...

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Bibliographic Details
Published in:	EMBO molecular medicine Vol. 15; no. 3; pp. e16959 - n/a
Main Authors:	Taubenschmid‐Stowers, Jasmin, Orthofer, Michael, Laemmerer, Anna, Krauditsch, Christian, Rózsová, Marianna, Studer, Christian, Lötsch, Daniela, Gojo, Johannes, Gabler, Lisa, Dyczynski, Matheus, Efferth, Thomas, Hagelkruys, Astrid, Widhalm, Georg, Peyrl, Andreas, Spiegl‐Kreinecker, Sabine, Hoepfner, Dominic, Bian, Shan, Berger, Walter, Knoblich, Juergen A, Elling, Ulrich, Horn, Moritz, Penninger, Josef M
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.03.2023 EMBO Press John Wiley and Sons Inc Springer Nature
Subjects:	5‐ALA Aminolevulinic Acid Antimalarials - pharmacology Artemisinin Artemisinins - pharmacology Artemisinins - therapeutic use Biosynthesis Brain cancer Brain Neoplasms - drug therapy Brain tumors Breast cancer Carbon Cytotoxicity Dihydroartemisinin Drug resistance EMBO03 EMBO08 Genetic engineering genome wide screen Genomes Glioblastoma glioblastoma therapy Glycerol Heme Heme - metabolism Humans Malaria Mutagenesis Organoids porphyrin biogenesis Porphyrins Proteins Spheroids Stem cells Tumor cells Tumors Xenografts Yeast genome wide screen porphyrin biogenesis 5‐ALA glioblastoma therapy Artemisinin 5-ALA
ISSN:	1757-4676, 1757-4684, 1757-4684
Online Access:	Get full text
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