Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism dis...

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Bibliographic Details
Published in:Journal of cachexia, sarcopenia and muscle Vol. 8; no. 5; pp. 686 - 701
Main Authors: Molina, Pablo, Carrero, Juan J., Bover, Jordi, Chauveau, Philippe, Mazzaferro, Sandro, Torres, Pablo Ureña
Format: Journal Article
Language:English
Published: Germany John Wiley & Sons, Inc 01.10.2017
John Wiley and Sons Inc
Subjects:
Animals
Bone
Bone and Bones - metabolism
Bone Density
Bone Diseases, Metabolic - etiology
Bone Diseases, Metabolic - metabolism
Chronic kidney disease
Fibroblasts
Fractures
Gene expression
Growth factors
Homeostasis
Humans
Kidney diseases
Kinases
Metabolism
Mineralization
Muscle
Muscle function
Muscle Weakness - etiology
Muscle Weakness - metabolism
Muscles - metabolism
Muscular Diseases - etiology
Muscular Diseases - metabolism
Musculoskeletal System - metabolism
Nutrition
Phosphatase
Physical performance
Proteins
Receptors, Calcitriol - metabolism
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - etiology
Renal Insufficiency, Chronic - metabolism
Review
Reviews
Sarcopenia
Signal Transduction
Vitamin D
Vitamin D - metabolism
Vitamin D Deficiency - etiology
Vitamin D Deficiency - metabolism
Vitamin deficiency
Working groups
Italy
Netherlands
United Kingdom > UK
France
Germany
Spain
Chronic kidney disease
Muscle
Bone
Physical performance
Vitamin D
ISSN:2190-5991, 2190-6009, 2190-6009
Online Access:Get full text
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Description
Summary:The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. Here, we review how vitamin D represents a pathway in which bone and muscle may interact. In vitro studies have confirmed that the vitamin D receptor is present on muscle, describing the mechanisms whereby vitamin D directly affects skeletal muscle. These include genomic and non‐genomic (rapid) effects, regulating cellular differentiation and proliferation. Observational studies have shown that circulating 25‐hydroxyvitamin D levels correlate with the clinical symptoms and muscle morphological changes observed in CKD patients. Vitamin D deficiency has been linked to low bone formation rate and bone mineral density, with an increased risk of skeletal fractures. The impact of low vitamin D status on skeletal muscle may also affect muscle metabolic pathways, including its sensitivity to insulin. Although some interventional studies have shown that vitamin D may improve physical performance and protect against the development of histological and radiological signs of hyperparathyroidism, evidence is still insufficient to draw definitive conclusions.
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Board members of the ERN and CKD‐MBD working groups are listed in the Acknowledgements
ISSN:2190-5991
2190-6009
2190-6009
DOI:10.1002/jcsm.12218