Stabilizer-Guided Inhibition of Protein-Protein Interactions

The discovery of novel protein–protein interaction (PPI) modulators represents one of the great molecular challenges of the modern era. PPIs can be modulated by either inhibitor or stabilizer compounds, which target different though proximal regions of the protein interface. In principle, protein–st...

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Veröffentlicht in:	Angewandte Chemie International Edition Jg. 54; H. 52; S. 15720 - 15724
Hauptverfasser:	Milroy, Lech-Gustav, Bartel, Maria, Henen, Morkos A., Leysen, Seppe, Adriaans, Joris M. C., Brunsveld, Luc, Landrieu, Isabelle, Ottmann, Christian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Weinheim WILEY-VCH Verlag 21.12.2015 WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc Wiley-VCH Verlag
Ausgabe:	International ed. in English
Schlagworte:	14-3-3 Proteins - chemistry Adapter proteins Adapters Alzheimer's disease Biochemistry, Molecular Biology Chemical Sciences Chemistry Chemistry, Multidisciplinary Crystallography drug discovery Inhibitors Life Sciences Magnetic resonance spectroscopy Medicinal Chemistry Modulators Neurodegenerative diseases NMR NMR spectroscopy Nuclear magnetic resonance peptide inhibitors Physical Sciences Protein Binding Protein interaction protein-protein interactions Proteins Science & Technology Structural Biology structure-guided design Tau protein Therapeutic targets drug discovery INTERFACE PHOSPHORYLATION MICROTUBULES SMALL-MOLECULE INHIBITORS peptide inhibitors TAU BINDING protein-protein interactions structure-guided design
ISSN:	1433-7851, 1521-3773, 1521-3773
Online-Zugang:	Volltext
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