Roles of extracellular vesicles in the aging microenvironment and age‐related diseases

Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double‐edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically ha...

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Vydáno v:Journal of extracellular vesicles Ročník 10; číslo 12; s. e12154 - n/a
Hlavní autoři: Yin, Yujia, Chen, Huihui, Wang, Yizhi, Zhang, Ludi, Wang, Xipeng
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States John Wiley & Sons, Inc 01.10.2021
John Wiley and Sons Inc
Wiley
Témata:
age‐related diseases
Aging
Aging - genetics
aging microenvironment
antiaging therapy
Autophagy
Biosynthesis
Cell cycle
Cell death
Cell interactions
Cellular Senescence
Cyclin-dependent kinases
DNA damage
Extracellular vesicles
Extracellular Vesicles - metabolism
Gene expression
Homeostasis
Humans
Kinases
Metabolism
Metabolites
Microenvironments
Mitochondria
Mutation
Paracrine signalling
Phosphorylation
Proteins
Review
Senescence
Signal Transduction
age-related diseases
aging microenvironment
cellular senescence
extracellular vesicles
antiaging therapy
ISSN:2001-3078, 2001-3078
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Abstract Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double‐edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically harmful in age‐related diseases. Among the hallmarks of senescence, the SASP, especially SASP‐related extracellular vesicle (EV) signalling, plays the leading role in aging transmission via paracrine and endocrine mechanisms. EVs are successful in intercellular and interorgan communication in the aging microenvironment and age‐related diseases. They have detrimental effects on downstream targets at the levels of immunity, inflammation, gene expression, and metabolism. Furthermore, EVs obtained from different donors are also promising materials and tools for antiaging treatments and are used for regeneration and rejuvenation in cell‐free systems. Here, we describe the characteristics of cellular senescence and the aging microenvironment, concentrating on the production and function of EVs in age‐related diseases, and provide new ideas for antiaging therapy with EVs.
AbstractList Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double‐edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically harmful in age‐related diseases. Among the hallmarks of senescence, the SASP, especially SASP‐related extracellular vesicle (EV) signalling, plays the leading role in aging transmission via paracrine and endocrine mechanisms. EVs are successful in intercellular and interorgan communication in the aging microenvironment and age‐related diseases. They have detrimental effects on downstream targets at the levels of immunity, inflammation, gene expression, and metabolism. Furthermore, EVs obtained from different donors are also promising materials and tools for antiaging treatments and are used for regeneration and rejuvenation in cell‐free systems. Here, we describe the characteristics of cellular senescence and the aging microenvironment, concentrating on the production and function of EVs in age‐related diseases, and provide new ideas for antiaging therapy with EVs.
Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double-edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically harmful in age-related diseases. Among the hallmarks of senescence, the SASP, especially SASP-related extracellular vesicle (EV) signalling, plays the leading role in aging transmission via paracrine and endocrine mechanisms. EVs are successful in intercellular and interorgan communication in the aging microenvironment and age-related diseases. They have detrimental effects on downstream targets at the levels of immunity, inflammation, gene expression, and metabolism. Furthermore, EVs obtained from different donors are also promising materials and tools for antiaging treatments and are used for regeneration and rejuvenation in cell-free systems. Here, we describe the characteristics of cellular senescence and the aging microenvironment, concentrating on the production and function of EVs in age-related diseases, and provide new ideas for antiaging therapy with EVs.Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double-edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically harmful in age-related diseases. Among the hallmarks of senescence, the SASP, especially SASP-related extracellular vesicle (EV) signalling, plays the leading role in aging transmission via paracrine and endocrine mechanisms. EVs are successful in intercellular and interorgan communication in the aging microenvironment and age-related diseases. They have detrimental effects on downstream targets at the levels of immunity, inflammation, gene expression, and metabolism. Furthermore, EVs obtained from different donors are also promising materials and tools for antiaging treatments and are used for regeneration and rejuvenation in cell-free systems. Here, we describe the characteristics of cellular senescence and the aging microenvironment, concentrating on the production and function of EVs in age-related diseases, and provide new ideas for antiaging therapy with EVs.
Abstract Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double‐edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically harmful in age‐related diseases. Among the hallmarks of senescence, the SASP, especially SASP‐related extracellular vesicle (EV) signalling, plays the leading role in aging transmission via paracrine and endocrine mechanisms. EVs are successful in intercellular and interorgan communication in the aging microenvironment and age‐related diseases. They have detrimental effects on downstream targets at the levels of immunity, inflammation, gene expression, and metabolism. Furthermore, EVs obtained from different donors are also promising materials and tools for antiaging treatments and are used for regeneration and rejuvenation in cell‐free systems. Here, we describe the characteristics of cellular senescence and the aging microenvironment, concentrating on the production and function of EVs in age‐related diseases, and provide new ideas for antiaging therapy with EVs.
Author Chen, Huihui
Yin, Yujia
Wang, Xipeng
Zhang, Ludi
Wang, Yizhi
AuthorAffiliation 1 Department of Obstetrics and Gynecology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
2 State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences Chinese Academy of Sciences, University of Chinese Academy of Sciences Shanghai China
AuthorAffiliation_xml – name: 2 State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences Chinese Academy of Sciences, University of Chinese Academy of Sciences Shanghai China
– name: 1 Department of Obstetrics and Gynecology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
Author_xml – sequence: 1
  givenname: Yujia
  surname: Yin
  fullname: Yin, Yujia
  organization: Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
– sequence: 2
  givenname: Huihui
  surname: Chen
  fullname: Chen, Huihui
  organization: Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
– sequence: 3
  givenname: Yizhi
  surname: Wang
  fullname: Wang, Yizhi
  organization: Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
– sequence: 4
  givenname: Ludi
  surname: Zhang
  fullname: Zhang, Ludi
  organization: Chinese Academy of Sciences, University of Chinese Academy of Sciences
– sequence: 5
  givenname: Xipeng
  surname: Wang
  fullname: Wang, Xipeng
  email: wangxipeng@xinhuamed.com.cn
  organization: Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34609061$$D View this record in MEDLINE/PubMed
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Copyright 2021 The Authors. published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles
2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.
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– notice: 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Keywords age-related diseases
aging microenvironment
cellular senescence
extracellular vesicles
antiaging therapy
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2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.
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Snippet Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double‐edged...
Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double-edged...
Abstract Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a...
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SubjectTerms age‐related diseases
Aging
Aging - genetics
aging microenvironment
antiaging therapy
Autophagy
Biosynthesis
Cell cycle
Cell death
Cell interactions
Cellular Senescence
Cyclin-dependent kinases
DNA damage
Extracellular vesicles
Extracellular Vesicles - metabolism
Gene expression
Homeostasis
Humans
Kinases
Metabolism
Metabolites
Microenvironments
Mitochondria
Mutation
Paracrine signalling
Phosphorylation
Proteins
Review
Senescence
Signal Transduction
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Title Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjev2.12154
https://www.ncbi.nlm.nih.gov/pubmed/34609061
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https://pubmed.ncbi.nlm.nih.gov/PMC8491204
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Volume 10
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