Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats

Intraoperative bioprinting (IOB), which refers to the bioprinting process performed on a live subject in a surgical setting, has made it feasible to directly deliver gene-activated matrices into craniomaxillofacial (CMF) defect sites. In this study, we demonstrated a novel approach to overcome the c...

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Bibliographic Details
Published in:	Biomaterials Vol. 281; p. 121333
Main Authors:	Moncal, Kazim K., Tigli Aydın, R. Seda, Godzik, Kevin P., Acri, Timothy M., Heo, Dong N., Rizk, Elias, Wee, Hwabok, Lewis, Gregory S., Salem, Aliasger K., Ozbolat, Ibrahim T.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.02.2022
Subjects:	Animals biocompatible materials bioprinting Bioprinting - methods Bone and Bones bone formation Bone Morphogenetic Protein 2 - pharmacology bone morphogenetic proteins Bone Regeneration - genetics bones Controlled co-delivery gene transfer Gene Transfer Techniques Humans In-situ delivery Intraoperative bioprinting Osteogenesis Plasmid-DNAs Rats Controlled co-delivery Plasmid-DNAs In-situ delivery Intraoperative bioprinting
ISSN:	0142-9612, 1878-5905, 1878-5905
Online Access:	Get full text
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