Cervical spinal demyelination with ethidium bromide impairs respiratory (phrenic) activity and forelimb motor behavior in rats

► Spinal ethidium bromide injections produced transient dorsolateral demyelination. ► Ventilation did not change with ethidium bromide (EB) demyelination. ► Ipsilateral phrenic nerve amplitude was transiently reduced post-EB. ► Ipsilateral limb function was continually impaired post-EB. ► EB provide...

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Veröffentlicht in:	Neuroscience Jg. 229; S. 77 - 87
Hauptverfasser:	Nichols, N.L., Punzo, A.M., Duncan, I.D., Mitchell, G.S., Johnson, R.A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Amsterdam Elsevier Ltd 15.01.2013 Elsevier
Schlagworte:	Animals Biological and medical sciences Cervical Vertebrae compensatory plasticity Demyelinating Diseases - chemically induced Demyelinating Diseases - physiopathology Diaphragm - innervation Diaphragm - physiopathology Ethidium Forelimb - physiology Fundamental and applied biological sciences. Psychology Motor Activity - physiology Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration motor function Motor Neurons - physiology myelin Neurology Phrenic Nerve - physiopathology phrenic nerve amplitude Rats Rats, Sprague-Dawley Respiration Spinal cord Spinal Cord - physiopathology ventilation Vertebrates: nervous system and sense organs Walking - physiology PBS myelin Spinal cord V˙E VT/TI f FIO2 ventilation CNS PETCO2 PaO2 ANOVA TI phrenic nerve amplitude motor function LSD EB VT compensatory plasticity FIO 2 phosphate-buffered saline V T inspiratory fraction of oxygen analysis of variance mean inspiratory flow tidal volume P ETCO 2 arterial partial pressure of oxygen V ˙ E inspiratory time PaO 2 breathing frequency Fisher’s least significant difference V T/ T I central nervous system minute ventilation (the product of breathing frequency and tidal volume) partial pressure of end-tidal carbon dioxide T I ethidium bromide Rat Myelin Rodentia Central nervous system Respiratory system Motor control Vertebrata Mammalia Phrenic nerve Demyelination Animal Plasticity Upper limb Behavior Pulmonary ventilation Respiration Forelimb
ISSN:	0306-4522, 1873-7544, 1873-7544
Online-Zugang:	Volltext
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