Evaluation of dose reduction versus standard dosing for maintenance of remission in patients with spondyloarthritis and clinical remission with anti-TNF (REDES-TNF): study protocol for a randomized controlled trial

Background Dose reduction schedules of tumor necrosis factor antagonists (anti-TNF) as maintenance therapy in patients with spondyloarthritis are used empirically in clinical practice, despite the lack of clinical trials providing evidence for this practice. Methods/Design To address this issue the...

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Bibliographic Details
Published in:	Current controlled trials in cardiovascular medicine Vol. 16; no. 1; pp. 370 - 381
Main Authors:	Pontes, Caridad, Gratacós, Jordi, Torres, Ferran, Avendaño, Cristina, Sanz, Jesús, Vallano, Antoni, Juanola, Xavier, de Miguel, Eugenio, Sanmartí, Raimon, Calvo, Gonzalo
Format:	Journal Article
Language:	English
Published:	London BioMed Central 20.08.2015 BioMed Central Ltd Springer Nature B.V
Subjects:	Administració de medicaments Administration of drugs Ankylosing spondylitis Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - adverse effects Arthritis Assaigs clínics Biological Products - administration & dosage Biological Products - adverse effects Biomechanical Phenomena Biomedicine Clinical Protocols Clinical trials Decision Support Techniques Disease Drug Administration Schedule Drug dosages Drug withdrawal Espondiloartritis anquilosant Health Sciences Humans Joints diseases Malalties de les articulacions Medical protocols Medical research Medicine Medicine & Public Health Medicine, Experimental Pain Patients Pharmaceutical industry Product development Prospective Studies Protocols clínics Quality of life Recovery of Function Remission (Medicine) Remission Induction Research Design Reumatisme Rheumatism Rheumatology Spain Spine - drug effects Spine - immunology Spine - physiopathology Spondylarthritis - diagnosis Spondylarthritis - drug therapy Spondylarthritis - immunology Spondylarthritis - physiopathology Statistics for Life Sciences Study Protocol Time Factors Treatment Outcome Tumor necrosis factor Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-TNF Spain United States DMARDs (biologic) Disease Activity Spondyloarthritis/therapy Treatment
ISSN:	1745-6215, 1745-6215
Online Access:	Get full text
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