Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6

The identification of regulatory networks contributing to fetal/adult gene expression switches is a major challenge in developmental biology and key to understand the aberrant proliferation of cancer cells, which often reactivate fetal oncogenes. One key example is represented by the developmental g...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; pp. 10287 - 12
Main Authors:	Pastori, Valentina, Zambanini, Gianluca, Citterio, Elisabetta, Weiss, Tamina, Nakamura, Yukio, Cantù, Claudio, Ronchi, Antonella Ellena
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.05.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/136 631/208 692/4028 Cancer Cell Line, Tumor Cell proliferation Developmental biology Down-regulation Erythroid cells Erythroid Cells - metabolism Erythropoiesis Erythropoiesis - genetics Fetuses Gene expression Gene Expression Regulation, Developmental Gene Expression Regulation, Neoplastic Gene regulation Gene silencing Hep G2 Cells Humanities and Social Sciences Humans K562 Cells MicroRNAs - genetics MicroRNAs - metabolism multidisciplinary Myc protein RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Science Science (multidisciplinary) SOXD Transcription Factors - genetics SOXD Transcription Factors - metabolism Transcription factors
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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