Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability

Genomic copy number variants (CNVs) are routinely identified and reported back to patients with neuropsychiatric disorders, but their quantitative effects on essential traits such as cognitive ability are poorly documented. We have recently shown that the effect size of deletions on cognitive abilit...

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Bibliographic Details
Published in:	Molecular psychiatry Vol. 26; no. 6; pp. 2663 - 2676
Main Authors:	Huguet, Guillaume, Schramm, Catherine, Douard, Elise, Tamer, Petra, Main, Antoine, Monin, Pauline, England, Jade, Jizi, Khadije, Renne, Thomas, Poirier, Myriam, Nowak, Sabrina, Martin, Charles-Olivier, Younis, Nadine, Knoth, Inga Sophia, Jean-Louis, Martineau, Saci, Zohra, Auger, Maude, Tihy, Frédérique, Mathonnet, Géraldine, Maftei, Catalina, Léveillé, France, Porteous, David, Davies, Gail, Redmond, Paul, Harris, Sarah E, Hill, W David, Lemyre, Emmanuelle, Schumann, Gunter, Bourgeron, Thomas, Pausova, Zdenka, Paus, Tomas, Karama, Sherif, Lippe, Sarah, Deary, Ian J, Almasy, Laura, Labbe, Aurélie, Glahn, David, Greenwood, Celia M T, Jacquemont, Sébastien
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.06.2021
Subjects:	Autism Cognition Cognitive ability Copy number DNA Copy Number Variations - genetics Gene Dosage Gene regulation Genes Genome Genomes Haploinsufficiency Heredity Humans Intelligence Intelligence Tests Intolerance Mathematical models Mental disorders Statistical analysis
ISSN:	1359-4184, 1476-5578, 1476-5578
Online Access:	Get full text
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