Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability

Genomic copy number variants (CNVs) are routinely identified and reported back to patients with neuropsychiatric disorders, but their quantitative effects on essential traits such as cognitive ability are poorly documented. We have recently shown that the effect size of deletions on cognitive abilit...

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Vydáno v:	Molecular psychiatry Ročník 26; číslo 6; s. 2663 - 2676
Hlavní autoři:	Huguet, Guillaume, Schramm, Catherine, Douard, Elise, Tamer, Petra, Main, Antoine, Monin, Pauline, England, Jade, Jizi, Khadije, Renne, Thomas, Poirier, Myriam, Nowak, Sabrina, Martin, Charles-Olivier, Younis, Nadine, Knoth, Inga Sophia, Jean-Louis, Martineau, Saci, Zohra, Auger, Maude, Tihy, Frédérique, Mathonnet, Géraldine, Maftei, Catalina, Léveillé, France, Porteous, David, Davies, Gail, Redmond, Paul, Harris, Sarah E, Hill, W David, Lemyre, Emmanuelle, Schumann, Gunter, Bourgeron, Thomas, Pausova, Zdenka, Paus, Tomas, Karama, Sherif, Lippe, Sarah, Deary, Ian J, Almasy, Laura, Labbe, Aurélie, Glahn, David, Greenwood, Celia M T, Jacquemont, Sébastien
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.06.2021
Témata:	Autism Cognition Cognitive ability Copy number DNA Copy Number Variations - genetics Gene Dosage Gene regulation Genes Genome Genomes Haploinsufficiency Heredity Humans Intelligence Intelligence Tests Intolerance Mathematical models Mental disorders Statistical analysis
ISSN:	1359-4184, 1476-5578, 1476-5578
On-line přístup:	Získat plný text
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