Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability

Genomic copy number variants (CNVs) are routinely identified and reported back to patients with neuropsychiatric disorders, but their quantitative effects on essential traits such as cognitive ability are poorly documented. We have recently shown that the effect size of deletions on cognitive abilit...

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Veröffentlicht in:	Molecular psychiatry Jg. 26; H. 6; S. 2663 - 2676
Hauptverfasser:	Huguet, Guillaume, Schramm, Catherine, Douard, Elise, Tamer, Petra, Main, Antoine, Monin, Pauline, England, Jade, Jizi, Khadije, Renne, Thomas, Poirier, Myriam, Nowak, Sabrina, Martin, Charles-Olivier, Younis, Nadine, Knoth, Inga Sophia, Jean-Louis, Martineau, Saci, Zohra, Auger, Maude, Tihy, Frédérique, Mathonnet, Géraldine, Maftei, Catalina, Léveillé, France, Porteous, David, Davies, Gail, Redmond, Paul, Harris, Sarah E, Hill, W David, Lemyre, Emmanuelle, Schumann, Gunter, Bourgeron, Thomas, Pausova, Zdenka, Paus, Tomas, Karama, Sherif, Lippe, Sarah, Deary, Ian J, Almasy, Laura, Labbe, Aurélie, Glahn, David, Greenwood, Celia M T, Jacquemont, Sébastien
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.06.2021
Schlagworte:	Autism Cognition Cognitive ability Copy number DNA Copy Number Variations - genetics Gene Dosage Gene regulation Genes Genome Genomes Haploinsufficiency Heredity Humans Intelligence Intelligence Tests Intolerance Mathematical models Mental disorders Statistical analysis
ISSN:	1359-4184, 1476-5578, 1476-5578
Online-Zugang:	Volltext
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