Precise physical models of protein-DNA interaction from high-throughput data

A cell's ability to regulate gene transcription depends in large part on the energy with which transcription factors (TFs) bind their DNA regulatory sites. Obtaining accurate models of this binding energy is therefore an important goal for quantitative biology. In this article, we present a pri...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 2; p. 501
Main Authors:	Kinney, Justin B, Tkacik, Gasper, Callan, Jr, Curtis G
Format:	Journal Article
Language:	English
Published:	United States 09.01.2007
Subjects:	Binding Sites Biophysical Phenomena Biophysics DNA - chemistry DNA - metabolism DNA, Fungal - chemistry DNA, Fungal - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Likelihood Functions Models, Chemical Protein Array Analysis Protein Binding Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Thermodynamics Transcription Factors - chemistry Transcription Factors - metabolism
ISSN:	0027-8424
Online Access:	Get more information
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