Precise physical models of protein-DNA interaction from high-throughput data

A cell's ability to regulate gene transcription depends in large part on the energy with which transcription factors (TFs) bind their DNA regulatory sites. Obtaining accurate models of this binding energy is therefore an important goal for quantitative biology. In this article, we present a pri...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 104; číslo 2; s. 501
Hlavní autoři:	Kinney, Justin B, Tkacik, Gasper, Callan, Jr, Curtis G
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 09.01.2007
Témata:	Binding Sites Biophysical Phenomena Biophysics DNA - chemistry DNA - metabolism DNA, Fungal - chemistry DNA, Fungal - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Likelihood Functions Models, Chemical Protein Array Analysis Protein Binding Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Thermodynamics Transcription Factors - chemistry Transcription Factors - metabolism
ISSN:	0027-8424
On-line přístup:	Zjistit podrobnosti o přístupu
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