Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening pl...

Full description

Saved in:
Bibliographic Details
Published in:Nature communications Vol. 14; no. 1; pp. 6785 - 16
Main Authors: Monteil, Vanessa, Kwon, Hyesoo, John, Lijo, Salata, Cristiano, Jonsson, Gustav, Vorrink, Sabine U., Appelberg, Sofia, Youhanna, Sonia, Dyczynski, Matheus, Leopoldi, Alexandra, Leeb, Nicole, Volz, Jennifer, Hagelkruys, Astrid, Kellner, Max J., Devignot, Stéphanie, Michlits, Georg, Foong-Sobis, Michelle, Weber, Friedemann, Lauschke, Volker M., Horn, Moritz, Feldmann, Heinz, Elling, Ulrich, Penninger, Josef M., Mirazimi, Ali
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 25.10.2023
Nature Publishing Group
Nature Portfolio
Subjects:
13/1
13/100
13/31
14/19
631/326/596/2041
631/326/596/2042
631/326/596/2557
631/326/596/4130
82/29
Animals
Blood vessels
Cell lines
Cell migration
Ebola virus
Ebolavirus
Ebolavirus - metabolism
Endocytosis
Endosomes
Filoviridae
Guanine nucleotide exchange factor
Guanine Nucleotide Exchange Factors - metabolism
Hemorrhagic Fever, Ebola
Humanities and Social Sciences
Humans
Infections
Lysosomes
Marburg Virus Disease - genetics
Marburg Virus Disease - metabolism
Marburgvirus
Marburgvirus - metabolism
multidisciplinary
Nucleotides
Organoids
Protein transport
Receptors
Science
Science (multidisciplinary)
Screening
Severe acute respiratory syndrome coronavirus 2
Therapeutic targets
Trafficking
Tropism
Vesicular Transport Proteins - metabolism
Viral diseases
Viruses
ISSN:2041-1723, 2041-1723
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication. The critical role of CCZ1 for filovirus infections is validated in 3D primary human hepatocyte cultures and human blood-vessel organoids, both critical target sites for Ebola and Marburg virus tropism. Mechanistically, CCZ1 controls early to late endosomal trafficking of these viruses. In addition, we report that CCZ1 has a role in the endosomal trafficking of endocytosis-dependent SARS-CoV-2 infections, but not in infections by Lassa virus, which enters endo-lysosomal trafficking at the late endosome stage. Thus, we have identified an essential host pathway for filovirus infections in cell lines and engineered human target tissues. Inhibition of CCZ1 nearly completely abolishes Marburg and Ebola infections. Thus, targeting CCZ1 could potentially serve as a promising drug target for controlling infections caused by various viruses, such as SARS-CoV-2, Marburg, and Ebola. Host factors involved in filovirus infection are incompletely understood. Here, the authors used a haploid cell screening system to unveil CCZ1’s crucial role in regulating endosomal trafficking thus virus movement within cells and thereby impacting Marburg and Ebola infection.
AbstractList Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication. The critical role of CCZ1 for filovirus infections is validated in 3D primary human hepatocyte cultures and human blood-vessel organoids, both critical target sites for Ebola and Marburg virus tropism. Mechanistically, CCZ1 controls early to late endosomal trafficking of these viruses. In addition, we report that CCZ1 has a role in the endosomal trafficking of endocytosis-dependent SARS-CoV-2 infections, but not in infections by Lassa virus, which enters endo-lysosomal trafficking at the late endosome stage. Thus, we have identified an essential host pathway for filovirus infections in cell lines and engineered human target tissues. Inhibition of CCZ1 nearly completely abolishes Marburg and Ebola infections. Thus, targeting CCZ1 could potentially serve as a promising drug target for controlling infections caused by various viruses, such as SARS-CoV-2, Marburg, and Ebola.Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication. The critical role of CCZ1 for filovirus infections is validated in 3D primary human hepatocyte cultures and human blood-vessel organoids, both critical target sites for Ebola and Marburg virus tropism. Mechanistically, CCZ1 controls early to late endosomal trafficking of these viruses. In addition, we report that CCZ1 has a role in the endosomal trafficking of endocytosis-dependent SARS-CoV-2 infections, but not in infections by Lassa virus, which enters endo-lysosomal trafficking at the late endosome stage. Thus, we have identified an essential host pathway for filovirus infections in cell lines and engineered human target tissues. Inhibition of CCZ1 nearly completely abolishes Marburg and Ebola infections. Thus, targeting CCZ1 could potentially serve as a promising drug target for controlling infections caused by various viruses, such as SARS-CoV-2, Marburg, and Ebola.
Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication. The critical role of CCZ1 for filovirus infections is validated in 3D primary human hepatocyte cultures and human blood-vessel organoids, both critical target sites for Ebola and Marburg virus tropism. Mechanistically, CCZ1 controls early to late endosomal trafficking of these viruses. In addition, we report that CCZ1 has a role in the endosomal trafficking of endocytosis-dependent SARS-CoV-2 infections, but not in infections by Lassa virus, which enters endo-lysosomal trafficking at the late endosome stage. Thus, we have identified an essential host pathway for filovirus infections in cell lines and engineered human target tissues. Inhibition of CCZ1 nearly completely abolishes Marburg and Ebola infections. Thus, targeting CCZ1 could potentially serve as a promising drug target for controlling infections caused by various viruses, such as SARS-CoV-2, Marburg, and Ebola.
Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication. The critical role of CCZ1 for filovirus infections is validated in 3D primary human hepatocyte cultures and human blood-vessel organoids, both critical target sites for Ebola and Marburg virus tropism. Mechanistically, CCZ1 controls early to late endosomal trafficking of these viruses. In addition, we report that CCZ1 has a role in the endosomal trafficking of endocytosis-dependent SARS-CoV-2 infections, but not in infections by Lassa virus, which enters endo-lysosomal trafficking at the late endosome stage. Thus, we have identified an essential host pathway for filovirus infections in cell lines and engineered human target tissues. Inhibition of CCZ1 nearly completely abolishes Marburg and Ebola infections. Thus, targeting CCZ1 could potentially serve as a promising drug target for controlling infections caused by various viruses, such as SARS-CoV-2, Marburg, and Ebola.Host factors involved in filovirus infection are incompletely understood. Here, the authors used a haploid cell screening system to unveil CCZ1’s crucial role in regulating endosomal trafficking thus virus movement within cells and thereby impacting Marburg and Ebola infection.
Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication. The critical role of CCZ1 for filovirus infections is validated in 3D primary human hepatocyte cultures and human blood-vessel organoids, both critical target sites for Ebola and Marburg virus tropism. Mechanistically, CCZ1 controls early to late endosomal trafficking of these viruses. In addition, we report that CCZ1 has a role in the endosomal trafficking of endocytosis-dependent SARS-CoV-2 infections, but not in infections by Lassa virus, which enters endo-lysosomal trafficking at the late endosome stage. Thus, we have identified an essential host pathway for filovirus infections in cell lines and engineered human target tissues. Inhibition of CCZ1 nearly completely abolishes Marburg and Ebola infections. Thus, targeting CCZ1 could potentially serve as a promising drug target for controlling infections caused by various viruses, such as SARS-CoV-2, Marburg, and Ebola. Host factors involved in filovirus infection are incompletely understood. Here, the authors used a haploid cell screening system to unveil CCZ1’s crucial role in regulating endosomal trafficking thus virus movement within cells and thereby impacting Marburg and Ebola infection.
Abstract Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication. The critical role of CCZ1 for filovirus infections is validated in 3D primary human hepatocyte cultures and human blood-vessel organoids, both critical target sites for Ebola and Marburg virus tropism. Mechanistically, CCZ1 controls early to late endosomal trafficking of these viruses. In addition, we report that CCZ1 has a role in the endosomal trafficking of endocytosis-dependent SARS-CoV-2 infections, but not in infections by Lassa virus, which enters endo-lysosomal trafficking at the late endosome stage. Thus, we have identified an essential host pathway for filovirus infections in cell lines and engineered human target tissues. Inhibition of CCZ1 nearly completely abolishes Marburg and Ebola infections. Thus, targeting CCZ1 could potentially serve as a promising drug target for controlling infections caused by various viruses, such as SARS-CoV-2, Marburg, and Ebola.
ArticleNumber 6785
Author Feldmann, Heinz
Michlits, Georg
Leopoldi, Alexandra
Leeb, Nicole
John, Lijo
Mirazimi, Ali
Vorrink, Sabine U.
Volz, Jennifer
Youhanna, Sonia
Devignot, Stéphanie
Appelberg, Sofia
Weber, Friedemann
Kellner, Max J.
Hagelkruys, Astrid
Kwon, Hyesoo
Elling, Ulrich
Jonsson, Gustav
Monteil, Vanessa
Horn, Moritz
Penninger, Josef M.
Salata, Cristiano
Lauschke, Volker M.
Dyczynski, Matheus
Foong-Sobis, Michelle
Author_xml – sequence: 1
  givenname: Vanessa
  orcidid: 0000-0002-2652-5695
  surname: Monteil
  fullname: Monteil, Vanessa
  organization: Karolinska Institute and Karolinska University Hospital, Department of Laboratory Medicine, Unit of Clinical Microbiology
– sequence: 2
  givenname: Hyesoo
  orcidid: 0000-0003-4637-4609
  surname: Kwon
  fullname: Kwon, Hyesoo
  organization: National Veterinary Institute
– sequence: 3
  givenname: Lijo
  surname: John
  fullname: John, Lijo
  organization: National Veterinary Institute
– sequence: 4
  givenname: Cristiano
  orcidid: 0000-0002-5136-7406
  surname: Salata
  fullname: Salata, Cristiano
  organization: Department of Molecular Medicine, University of Padova
– sequence: 5
  givenname: Gustav
  orcidid: 0000-0001-6692-8395
  surname: Jonsson
  fullname: Jonsson, Gustav
  organization: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Science, Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna
– sequence: 6
  givenname: Sabine U.
  surname: Vorrink
  fullname: Vorrink, Sabine U.
  organization: Department of Physiology and Pharmacology, Karolinska Institutet
– sequence: 7
  givenname: Sofia
  orcidid: 0000-0002-7381-3606
  surname: Appelberg
  fullname: Appelberg, Sofia
  organization: Public Health Agency of Sweden
– sequence: 8
  givenname: Sonia
  surname: Youhanna
  fullname: Youhanna, Sonia
  organization: Department of Physiology and Pharmacology, Karolinska Institutet
– sequence: 9
  givenname: Matheus
  surname: Dyczynski
  fullname: Dyczynski, Matheus
  organization: Acus Laboratories GmbH, JLP Health GmbH
– sequence: 10
  givenname: Alexandra
  surname: Leopoldi
  fullname: Leopoldi, Alexandra
  organization: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Science
– sequence: 11
  givenname: Nicole
  surname: Leeb
  fullname: Leeb, Nicole
  organization: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Science
– sequence: 12
  givenname: Jennifer
  surname: Volz
  fullname: Volz, Jennifer
  organization: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Science
– sequence: 13
  givenname: Astrid
  orcidid: 0000-0003-3015-4038
  surname: Hagelkruys
  fullname: Hagelkruys, Astrid
  organization: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Science
– sequence: 14
  givenname: Max J.
  surname: Kellner
  fullname: Kellner, Max J.
  organization: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Science, Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna
– sequence: 15
  givenname: Stéphanie
  orcidid: 0000-0002-0618-5611
  surname: Devignot
  fullname: Devignot, Stéphanie
  organization: Karolinska Institute and Karolinska University Hospital, Department of Laboratory Medicine, Unit of Clinical Microbiology
– sequence: 16
  givenname: Georg
  orcidid: 0000-0002-3337-8291
  surname: Michlits
  fullname: Michlits, Georg
  organization: Acus Laboratories GmbH, JLP Health GmbH
– sequence: 17
  givenname: Michelle
  surname: Foong-Sobis
  fullname: Foong-Sobis, Michelle
  organization: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Science
– sequence: 18
  givenname: Friedemann
  orcidid: 0000-0001-9737-337X
  surname: Weber
  fullname: Weber, Friedemann
  organization: Institute for Virology, FB10-Veterinary Medicine, Justus Liebig University
– sequence: 19
  givenname: Volker M.
  orcidid: 0000-0002-1140-6204
  surname: Lauschke
  fullname: Lauschke, Volker M.
  organization: Department of Physiology and Pharmacology, Karolinska Institutet, University Tübingen, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
– sequence: 20
  givenname: Moritz
  surname: Horn
  fullname: Horn, Moritz
  organization: Acus Laboratories GmbH, JLP Health GmbH
– sequence: 21
  givenname: Heinz
  orcidid: 0000-0001-9448-8227
  surname: Feldmann
  fullname: Feldmann, Heinz
  organization: Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 22
  givenname: Ulrich
  orcidid: 0000-0002-4514-2809
  surname: Elling
  fullname: Elling, Ulrich
  organization: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Science
– sequence: 23
  givenname: Josef M.
  orcidid: 0000-0002-8194-3777
  surname: Penninger
  fullname: Penninger, Josef M.
  organization: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Science, Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Department of Laboratory Medicine, Medical University of Vienna, Helmholtz Centre for Infection Research
– sequence: 24
  givenname: Ali
  orcidid: 0000-0003-2371-6055
  surname: Mirazimi
  fullname: Mirazimi, Ali
  email: ali.mirazimi@ki.se
  organization: Karolinska Institute and Karolinska University Hospital, Department of Laboratory Medicine, Unit of Clinical Microbiology, National Veterinary Institute, Public Health Agency of Sweden
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37880247$$D View this record in MEDLINE/PubMed
BookMark eNp9kk9v1DAQxSNUREvpF-CALHHpJeB_cewTQqsCKxVxgQsXy5nYwYvXLnZSqd8e724LbQ_1xZbnvZ-eZuZlcxRTtE3zmuB3BDP5vnDCRd9iylpOOypa8aw5oZiTlvSUHd17HzdnpWxwPUwRyfmL5pj1UmLK-5MmrEcbZ-88mNmniJJDq9VPgkxBJiJbyq5qAgo3JZW0ra85G1flv32cULbTEsycMvIRfTV5WPJUfSO6GFIw6NrnpdSSs7CDl1fNc2dCsWe392nz49PF99WX9vLb5_Xq42ULXa_mtoYcVS8x0L43QilhpeKSYdcLIrjiPTAGDEYqHHRkJCOmdADlMKiuGyRlp836wB2T2eir7Lcm3-hkvN5_pDxpk2cPwWrCJFAgYEYBXHZWDcYZQgcFnRldB5X14cC6WoatHaH2I5vwAPqwEv0vPaVrTbDAmGJWCee3hJz-LLbMeusL2BBMtGkpmsoamRKFZZW-fSTdpCXH2qudinSc1RZU1Zv7kf5luZtqFciDAHIqJVunwc_7-daEPtRoerdD-rBDuu6Q3u-QFtVKH1nv6E-a2MFUqjhONv-P_YTrL4y02PI
CitedBy_id crossref_primary_10_1021_acsomega_5c01888
crossref_primary_10_1093_lifemeta_loaf017
crossref_primary_10_1016_j_celrep_2024_114921
crossref_primary_10_1124_pharmrev_124_001433
crossref_primary_10_1038_s41564_024_01672_3
crossref_primary_10_1097_MS9_0000000000003213
crossref_primary_10_1038_s44298_024_00017_5
crossref_primary_10_1038_s41467_024_51356_z
crossref_primary_10_1016_j_antiviral_2024_105844
Cites_doi 10.1038/nature10348
10.1038/nbt.1857
10.1038/nature10380
10.15252/embj.2021107821
10.1126/science.1252480
10.1096/fj.201601375R
10.1371/journal.ppat.1002232
10.1016/j.stem.2011.10.012
10.1126/science.1233675
10.1073/pnas.0505577102
10.7554/eLife.74623
10.1016/S0092-8674(01)00418-4
10.1128/JVI.76.13.6841-6844.2002
10.1016/j.cell.2010.04.013
10.1126/science.1178955
10.1016/j.cell.2020.04.004
10.1016/j.cell.2016.05.022
10.1016/j.celrep.2021.109364
10.1038/s41596-019-0213-z
10.3390/v14071369
10.1038/emboj.2011.286
10.1093/bioinformatics/btq054
10.1124/dmd.116.074369
10.1128/JVI.05708-11
10.1093/infdis/jiv255
10.3390/v11010025
10.1371/journal.ppat.1003911
10.1016/j.febslet.2014.06.032
10.1038/s41579-019-0233-2
10.1128/JCM.39.11.4125-4130.2001
10.3390/v11030274
10.1016/j.cell.2010.03.011
10.1186/s13073-022-01013-1
10.1038/nature24027
10.18632/oncotarget.24305
10.1038/s41572-020-0147-3
10.1128/JVI.02160-18
10.3390/v12070784
10.1007/978-1-4939-9145-7_1
10.1371/journal.ppat.1001110
10.1038/s41564-021-00931-x
10.1038/emboj.2012.53
10.1038/nprot.2013.143
10.1371/journal.ppat.1001258
10.1128/JVI.00560-08
10.1128/JVI.00422-09
10.1038/nmeth.2089
10.26508/lsa.202302005
10.1371/journal.ppat.1003772
10.1128/JVI.80.8.4174-4178.2006
10.1038/s41467-018-08135-4
10.1126/science.abb3753
10.1099/vir.0.81749-0
10.1038/s41586-018-0858-8
10.1038/s41580-021-00418-x
10.1080/14787210.2017.1305888
10.1038/s43586-021-00093-4
10.1128/JVI.78.10.5458-5465.2004
ContentType Journal Article
Copyright The Author(s) 2023
2023. Springer Nature Limited.
The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Springer Nature Limited 2023
Copyright_xml – notice: The Author(s) 2023
– notice: 2023. Springer Nature Limited.
– notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Springer Nature Limited 2023
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
COVID
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-023-42526-6
DatabaseName Springer Nature OA Free Journals (WRLC)
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Computer Science Collection
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central
ProQuest Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
Coronavirus Research Database
ProQuest Central Korea
Engineering Research Database
ProQuest Health & Medical Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
Health & Medical Collection (Alumni Edition)
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Proquest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Coronavirus Research Database
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
CrossRef
MEDLINE
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: ProQuest Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 16
ExternalDocumentID oai_doaj_org_article_138c2c1cad6c485e9bafa12b9c5adf5c
PMC10600203
37880247
10_1038_s41467_023_42526_6
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Vetenskapsrådet (Swedish Research Council)
  grantid: 2018-05766
  funderid: https://doi.org/10.13039/501100004359
– fundername: Austrian Science Fund FWF
  grantid: Z 271
– fundername: ;
  grantid: 2018-05766
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LGEZI
LK8
LOTEE
M1P
M48
M7P
M~E
NADUK
NAO
NXXTH
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
AFFHD
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
COVID
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
5PM
ID FETCH-LOGICAL-c579t-184d9780c277a6996e894830f76164947c33c3cd26fc51d1d022bc9f0c955b823
IEDL.DBID DOA
ISICitedReferencesCount 10
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001096436800015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2041-1723
IngestDate Fri Oct 03 12:35:17 EDT 2025
Tue Nov 04 02:06:15 EST 2025
Sun Nov 09 09:19:42 EST 2025
Tue Oct 07 07:36:42 EDT 2025
Mon Jul 21 05:52:32 EDT 2025
Tue Nov 18 22:32:19 EST 2025
Sat Nov 29 03:29:31 EST 2025
Fri Feb 21 02:38:11 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2023. Springer Nature Limited.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c579t-184d9780c277a6996e894830f76164947c33c3cd26fc51d1d022bc9f0c955b823
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-4514-2809
0000-0002-5136-7406
0000-0002-1140-6204
0000-0002-2652-5695
0000-0001-6692-8395
0000-0002-3337-8291
0000-0003-3015-4038
0000-0002-7381-3606
0000-0002-0618-5611
0000-0001-9737-337X
0000-0002-8194-3777
0000-0003-2371-6055
0000-0003-4637-4609
0000-0001-9448-8227
OpenAccessLink https://doaj.org/article/138c2c1cad6c485e9bafa12b9c5adf5c
PMID 37880247
PQID 2881543761
PQPubID 546298
PageCount 16
ParticipantIDs doaj_primary_oai_doaj_org_article_138c2c1cad6c485e9bafa12b9c5adf5c
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10600203
proquest_miscellaneous_2882321908
proquest_journals_2881543761
pubmed_primary_37880247
crossref_citationtrail_10_1038_s41467_023_42526_6
crossref_primary_10_1038_s41467_023_42526_6
springer_journals_10_1038_s41467_023_42526_6
PublicationCentury 2000
PublicationDate 2023-10-25
PublicationDateYYYYMMDD 2023-10-25
PublicationDate_xml – month: 10
  year: 2023
  text: 2023-10-25
  day: 25
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2023
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Wrensch (CR17) 2015; 212
Vorrink (CR22) 2017; 31
Puray-Chavez (CR36) 2021; 36
Huotari, Helenius (CR28) 2011; 30
Jacob (CR1) 2020; 6
Yasuda (CR25) 2016; 129
Pasqual, Rojek, Masin, Chatton, Kunz (CR47) 2011; 7
Garbutt (CR15) 2004; 78
Monteil (CR33) 2020; 181
CR34
Elling, Penninger (CR54) 2014; 588
CR32
Brecher (CR4) 2012; 86
Gong (CR43) 2016; 165
Ren (CR37) 2006; 87
Elling (CR52) 2017; 550
Gibb, Norwood, Woollen, Henchal (CR60) 2001; 39
Simmons (CR49) 2005; 102
Saeed, Kolokoltsov, Albrecht, Davey (CR19) 2010; 6
Bell (CR20) 2017; 45
Volz, Schuller, Elling (CR53) 2019; 1953
CR2
Schornberg (CR46) 2006; 80
Hoenen, Groseth, Feldmann (CR3) 2019; 17
Cabrera, Ungermann (CR26) 2010; 141
Elling (CR14) 2011; 9
Carette (CR5) 2011; 29
Rojek, Sanchez, Nguyen, de la Torre, Kunz (CR48) 2008; 82
Timms (CR9) 2013; 9
Jae (CR18) 2013; 340
Chan (CR42) 2001; 106
Carette (CR6) 2011; 477
Quinn (CR45) 2009; 83
MacLean (CR58) 2010; 26
Hoffmann, Pöhlmann (CR51) 2021; 6
Grodzki (CR31) 2022; 14
Poteryaev, Datta, Ackema, Zerial, Spang (CR27) 2010; 141
Cote (CR13) 2011; 477
Salata, Calistri, Parolin, Baritussio, Palu (CR39) 2017; 15
CR55
Miller (CR41) 2012; 31
Huang (CR16) 2011; 7
Ran (CR57) 2013; 8
Schneider, Rasband, Eliceiri (CR59) 2012; 9
Jae (CR7) 2014; 344
Koch (CR38) 2021; 40
Horn (CR30) 2018; 9
Jackson, Farzan, Chen, Choe (CR35) 2022; 23
Bruchez (CR50) 2020; 370
Alvarez (CR44) 2002; 76
Flint (CR12) 2019; 10
Bell (CR21) 2016; 6
CR29
CR24
Luteijn (CR11) 2019; 93
Wimmer (CR23) 2019; 565
Bock (CR40) 2022; 2
Wimmer, Leopoldi, Aichinger, Kerjaschki, Penninger (CR56) 2019; 14
Carette (CR8) 2009; 326
Petersen (CR10) 2014; 10
TR Gibb (42526_CR60) 2001; 39
M Horn (42526_CR30) 2018; 9
U Elling (42526_CR14) 2011; 9
J Huotari (42526_CR28) 2011; 30
EH Miller (42526_CR41) 2012; 31
42526_CR34
F Wrensch (42526_CR17) 2015; 212
42526_CR32
CC Bell (42526_CR20) 2017; 45
C Salata (42526_CR39) 2017; 15
JE Carette (42526_CR6) 2011; 477
M Garbutt (42526_CR15) 2004; 78
K Schornberg (42526_CR46) 2006; 80
FA Ran (42526_CR57) 2013; 8
JE Carette (42526_CR8) 2009; 326
LT Jae (42526_CR18) 2013; 340
M Cabrera (42526_CR26) 2010; 141
RT Timms (42526_CR9) 2013; 9
CC Bell (42526_CR21) 2016; 6
U Elling (42526_CR54) 2014; 588
U Elling (42526_CR52) 2017; 550
M Hoffmann (42526_CR51) 2021; 6
MF Saeed (42526_CR19) 2010; 6
X Ren (42526_CR37) 2006; 87
IC Huang (42526_CR16) 2011; 7
JM Rojek (42526_CR48) 2008; 82
RA Wimmer (42526_CR23) 2019; 565
C Bock (42526_CR40) 2022; 2
A Bruchez (42526_CR50) 2020; 370
M Flint (42526_CR12) 2019; 10
X Gong (42526_CR43) 2016; 165
JC Volz (42526_CR53) 2019; 1953
RA Wimmer (42526_CR56) 2019; 14
M Cote (42526_CR13) 2011; 477
ST Jacob (42526_CR1) 2020; 6
SU Vorrink (42526_CR22) 2017; 31
CB Jackson (42526_CR35) 2022; 23
RD Luteijn (42526_CR11) 2019; 93
42526_CR55
V Monteil (42526_CR33) 2020; 181
J Petersen (42526_CR10) 2014; 10
SY Chan (42526_CR42) 2001; 106
B MacLean (42526_CR58) 2010; 26
S Yasuda (42526_CR25) 2016; 129
42526_CR2
K Quinn (42526_CR45) 2009; 83
42526_CR29
LT Jae (42526_CR7) 2014; 344
CA Schneider (42526_CR59) 2012; 9
M Puray-Chavez (42526_CR36) 2021; 36
42526_CR24
T Hoenen (42526_CR3) 2019; 17
G Simmons (42526_CR49) 2005; 102
D Poteryaev (42526_CR27) 2010; 141
CP Alvarez (42526_CR44) 2002; 76
M Brecher (42526_CR4) 2012; 86
M Grodzki (42526_CR31) 2022; 14
JE Carette (42526_CR5) 2011; 29
J Koch (42526_CR38) 2021; 40
G Pasqual (42526_CR47) 2011; 7
References_xml – volume: 102
  start-page: 11876
  year: 2005
  end-page: 11881
  ident: CR49
  article-title: Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 2
  start-page: 8
  year: 2022
  ident: CR40
  article-title: High-content CRISPR screening
  publication-title: Nat. Rev. Methods Prim.
– volume: 141
  start-page: 404
  year: 2010
  end-page: 406
  ident: CR26
  article-title: Guiding endosomal maturation
  publication-title: Cell
– volume: 340
  start-page: 479
  year: 2013
  end-page: 483
  ident: CR18
  article-title: Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry
  publication-title: Science
– volume: 15
  start-page: 483
  year: 2017
  end-page: 492
  ident: CR39
  article-title: Antiviral activity of cationic amphiphilic drugs
  publication-title: Expert Rev. Anti Infect. Ther.
– volume: 344
  start-page: 1506
  year: 2014
  end-page: 1510
  ident: CR7
  article-title: Virus entry. Lassa virus entry requires a trigger-induced receptor switch
  publication-title: Science
– volume: 78
  start-page: 5458
  year: 2004
  end-page: 5465
  ident: CR15
  article-title: Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses
  publication-title: J. Virol.
– ident: CR29
– volume: 8
  start-page: 2281
  year: 2013
  end-page: 2308
  ident: CR57
  article-title: Genome engineering using the CRISPR-Cas9 system
  publication-title: Nat. Protoc.
– volume: 6
  start-page: e1001110
  year: 2010
  ident: CR19
  article-title: Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes
  publication-title: PLoS Pathog.
– volume: 106
  start-page: 117
  year: 2001
  end-page: 126
  ident: CR42
  article-title: Folate receptor-alpha is a cofactor for cellular entry by Marburg and Ebola viruses
  publication-title: Cell
– volume: 7
  start-page: e1001258
  year: 2011
  ident: CR16
  article-title: Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus
  publication-title: PLoS Pathog.
– volume: 6
  start-page: 828
  year: 2021
  end-page: 829
  ident: CR51
  article-title: How SARS-CoV-2 makes the cut
  publication-title: Nat. Microbiol.
– volume: 17
  start-page: 593
  year: 2019
  end-page: 606
  ident: CR3
  article-title: Therapeutic strategies to target the Ebola virus life cycle
  publication-title: Nat. Rev. Microbiol.
– volume: 83
  start-page: 10176
  year: 2009
  end-page: 10186
  ident: CR45
  article-title: Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors
  publication-title: J. Virol.
– volume: 39
  start-page: 4125
  year: 2001
  end-page: 4130
  ident: CR60
  article-title: Development and evaluation of a fluorogenic 5’ nuclease assay to detect and differentiate between Ebola virus subtypes Zaire and Sudan
  publication-title: J. Clin. Microbiol.
– volume: 565
  start-page: 505
  year: 2019
  end-page: 510
  ident: CR23
  article-title: Human blood vessel organoids as a model of diabetic vasculopathy
  publication-title: Nature
– volume: 7
  start-page: e1002232
  year: 2011
  ident: CR47
  article-title: Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport
  publication-title: PLoS Pathog.
– volume: 31
  start-page: 2696
  year: 2017
  end-page: 2708
  ident: CR22
  article-title: Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics
  publication-title: FASEB J.
– volume: 9
  start-page: 563
  year: 2011
  end-page: 574
  ident: CR14
  article-title: FpMan
  publication-title: Cell Stem Cell
– volume: 40
  start-page: e107821
  year: 2021
  ident: CR38
  article-title: TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells
  publication-title: EMBO J.
– volume: 86
  start-page: 364
  year: 2012
  end-page: 372
  ident: CR4
  article-title: Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change
  publication-title: J. Virol.
– volume: 6
  start-page: 13
  year: 2020
  ident: CR1
  article-title: Ebola virus disease
  publication-title: Nat. Rev. Dis. Prim.
– volume: 29
  start-page: 542
  year: 2011
  end-page: 546
  ident: CR5
  article-title: Global gene disruption in human cells to assign genes to phenotypes by deep sequencing
  publication-title: Nat. Biotechnol.
– volume: 181
  start-page: 905
  year: 2020
  end-page: 913.e907
  ident: CR33
  article-title: Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2
  publication-title: Cell
– volume: 477
  start-page: 340
  year: 2011
  end-page: 343
  ident: CR6
  article-title: Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
  publication-title: Nature
– volume: 141
  start-page: 497
  year: 2010
  end-page: 508
  ident: CR27
  article-title: Identification of the switch in early-to-late endosome transition
  publication-title: Cell
– volume: 326
  start-page: 1231
  year: 2009
  end-page: 1235
  ident: CR8
  article-title: Haploid genetic screens in human cells identify host factors used by pathogens
  publication-title: Science
– ident: CR32
– volume: 1953
  start-page: 3
  year: 2019
  end-page: 21
  ident: CR53
  article-title: Using functional genetics in haploid cells for drug target identification
  publication-title: Methods Mol. Biol.
– volume: 14
  start-page: 3082
  year: 2019
  end-page: 3100
  ident: CR56
  article-title: Generation of blood vessel organoids from human pluripotent stem cells
  publication-title: Nat. Protoc.
– volume: 14
  year: 2022
  ident: CR31
  article-title: Genome-scale CRISPR screens identify host factors that promote human coronavirus infection
  publication-title: Genome Med.
– volume: 129
  start-page: 329
  year: 2016
  end-page: 340
  ident: CR25
  article-title: Mon1-Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells
  publication-title: J. Cell Sci.
– volume: 82
  start-page: 7677
  year: 2008
  end-page: 7687
  ident: CR48
  article-title: Different mechanisms of cell entry by human-pathogenic Old World and New World arenaviruses
  publication-title: J. Virol.
– ident: CR2
– volume: 550
  start-page: 114
  year: 2017
  end-page: 118
  ident: CR52
  article-title: A reversible haploid mouse embryonic stem cell biobank resource for functional genomics
  publication-title: Nature
– volume: 30
  start-page: 3481
  year: 2011
  end-page: 3500
  ident: CR28
  article-title: Endosome maturation
  publication-title: EMBO J.
– volume: 31
  start-page: 1947
  year: 2012
  end-page: 1960
  ident: CR41
  article-title: Ebola virus entry requires the host-programmed recognition of an intracellular receptor
  publication-title: EMBO J.
– volume: 370
  start-page: 241
  year: 2020
  end-page: 247
  ident: CR50
  article-title: MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses
  publication-title: Science
– volume: 588
  start-page: 2415
  year: 2014
  end-page: 2421
  ident: CR54
  article-title: Genome wide functional genetics in haploid cells
  publication-title: FEBS Lett.
– volume: 26
  start-page: 966
  year: 2010
  end-page: 968
  ident: CR58
  article-title: Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
  publication-title: Bioinformatics
– volume: 6
  year: 2016
  ident: CR21
  article-title: Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
  publication-title: Sci. Rep.
– volume: 10
  start-page: e1003911
  year: 2014
  ident: CR10
  article-title: The major cellular sterol regulatory pathway is required for Andes virus infection
  publication-title: PLoS Pathog.
– volume: 477
  start-page: 344
  year: 2011
  end-page: 348
  ident: CR13
  article-title: Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection
  publication-title: Nature
– volume: 165
  start-page: 1467
  year: 2016
  end-page: 1478
  ident: CR43
  article-title: Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
  publication-title: Cell
– volume: 80
  start-page: 4174
  year: 2006
  end-page: 4178
  ident: CR46
  article-title: Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein
  publication-title: J. Virol.
– volume: 9
  start-page: 9838
  year: 2018
  end-page: 9851
  ident: CR30
  article-title: Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells
  publication-title: Oncotarget
– volume: 87
  start-page: 1691
  year: 2006
  end-page: 1695
  ident: CR37
  article-title: Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus
  publication-title: J. Gen. Virol.
– volume: 23
  start-page: 3
  year: 2022
  end-page: 20
  ident: CR35
  article-title: Mechanisms of SARS-CoV-2 entry into cells
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 9
  start-page: e1003772
  year: 2013
  ident: CR9
  article-title: Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases
  publication-title: PLoS Pathog.
– volume: 10
  year: 2019
  ident: CR12
  article-title: A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
  publication-title: Nat. Commun.
– ident: CR34
– volume: 212
  start-page: S210
  year: 2015
  end-page: S218
  ident: CR17
  article-title: Interferon-induced transmembrane protein-mediated inhibition of host cell entry of Ebola viruses
  publication-title: J. Infect. Dis.
– volume: 45
  start-page: 419
  year: 2017
  end-page: 429
  ident: CR20
  article-title: Transcriptional, functional, and mechanistic comparisons of stem cell-derived hepatocytes, HepaRG cells, and three-dimensional human hepatocyte spheroids as predictive in vitro systems for drug-induced liver injury
  publication-title: Drug Metab. Dispos.
– ident: CR55
– volume: 9
  start-page: 671
  year: 2012
  end-page: 675
  ident: CR59
  article-title: NIH Image to ImageJ: 25 years of image analysis
  publication-title: Nat. Methods
– ident: CR24
– volume: 76
  start-page: 6841
  year: 2002
  end-page: 6844
  ident: CR44
  article-title: C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
  publication-title: J. Virol.
– volume: 93
  start-page: e02160
  year: 2019
  end-page: 02118
  ident: CR11
  article-title: A genome-wide haploid genetic screen identifies heparan sulfate-associated genes and the macropinocytosis modulator TMED10 as factors supporting vaccinia virus infection
  publication-title: J. Virol.
– volume: 36
  start-page: 109364
  year: 2021
  ident: CR36
  article-title: Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
  publication-title: Cell Rep.
– volume: 477
  start-page: 340
  year: 2011
  ident: 42526_CR6
  publication-title: Nature
  doi: 10.1038/nature10348
– volume: 29
  start-page: 542
  year: 2011
  ident: 42526_CR5
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1857
– volume: 477
  start-page: 344
  year: 2011
  ident: 42526_CR13
  publication-title: Nature
  doi: 10.1038/nature10380
– volume: 40
  start-page: e107821
  year: 2021
  ident: 42526_CR38
  publication-title: EMBO J.
  doi: 10.15252/embj.2021107821
– volume: 344
  start-page: 1506
  year: 2014
  ident: 42526_CR7
  publication-title: Science
  doi: 10.1126/science.1252480
– volume: 31
  start-page: 2696
  year: 2017
  ident: 42526_CR22
  publication-title: FASEB J.
  doi: 10.1096/fj.201601375R
– volume: 7
  start-page: e1002232
  year: 2011
  ident: 42526_CR47
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1002232
– volume: 9
  start-page: 563
  year: 2011
  ident: 42526_CR14
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2011.10.012
– volume: 340
  start-page: 479
  year: 2013
  ident: 42526_CR18
  publication-title: Science
  doi: 10.1126/science.1233675
– volume: 102
  start-page: 11876
  year: 2005
  ident: 42526_CR49
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0505577102
– ident: 42526_CR34
  doi: 10.7554/eLife.74623
– volume: 106
  start-page: 117
  year: 2001
  ident: 42526_CR42
  publication-title: Cell
  doi: 10.1016/S0092-8674(01)00418-4
– volume: 76
  start-page: 6841
  year: 2002
  ident: 42526_CR44
  publication-title: J. Virol.
  doi: 10.1128/JVI.76.13.6841-6844.2002
– volume: 6
  year: 2016
  ident: 42526_CR21
  publication-title: Sci. Rep.
– volume: 141
  start-page: 404
  year: 2010
  ident: 42526_CR26
  publication-title: Cell
  doi: 10.1016/j.cell.2010.04.013
– volume: 326
  start-page: 1231
  year: 2009
  ident: 42526_CR8
  publication-title: Science
  doi: 10.1126/science.1178955
– volume: 181
  start-page: 905
  year: 2020
  ident: 42526_CR33
  publication-title: Cell
  doi: 10.1016/j.cell.2020.04.004
– volume: 165
  start-page: 1467
  year: 2016
  ident: 42526_CR43
  publication-title: Cell
  doi: 10.1016/j.cell.2016.05.022
– volume: 36
  start-page: 109364
  year: 2021
  ident: 42526_CR36
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.109364
– volume: 14
  start-page: 3082
  year: 2019
  ident: 42526_CR56
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-019-0213-z
– ident: 42526_CR32
  doi: 10.3390/v14071369
– volume: 30
  start-page: 3481
  year: 2011
  ident: 42526_CR28
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.286
– volume: 26
  start-page: 966
  year: 2010
  ident: 42526_CR58
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq054
– volume: 45
  start-page: 419
  year: 2017
  ident: 42526_CR20
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.116.074369
– volume: 86
  start-page: 364
  year: 2012
  ident: 42526_CR4
  publication-title: J. Virol.
  doi: 10.1128/JVI.05708-11
– volume: 212
  start-page: S210
  year: 2015
  ident: 42526_CR17
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jiv255
– ident: 42526_CR2
  doi: 10.3390/v11010025
– volume: 10
  start-page: e1003911
  year: 2014
  ident: 42526_CR10
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1003911
– volume: 588
  start-page: 2415
  year: 2014
  ident: 42526_CR54
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2014.06.032
– volume: 17
  start-page: 593
  year: 2019
  ident: 42526_CR3
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/s41579-019-0233-2
– volume: 39
  start-page: 4125
  year: 2001
  ident: 42526_CR60
  publication-title: J. Clin. Microbiol.
  doi: 10.1128/JCM.39.11.4125-4130.2001
– ident: 42526_CR24
  doi: 10.3390/v11030274
– volume: 141
  start-page: 497
  year: 2010
  ident: 42526_CR27
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.011
– volume: 14
  year: 2022
  ident: 42526_CR31
  publication-title: Genome Med.
  doi: 10.1186/s13073-022-01013-1
– volume: 550
  start-page: 114
  year: 2017
  ident: 42526_CR52
  publication-title: Nature
  doi: 10.1038/nature24027
– volume: 9
  start-page: 9838
  year: 2018
  ident: 42526_CR30
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.24305
– volume: 6
  start-page: 13
  year: 2020
  ident: 42526_CR1
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/s41572-020-0147-3
– volume: 93
  start-page: e02160
  year: 2019
  ident: 42526_CR11
  publication-title: J. Virol.
  doi: 10.1128/JVI.02160-18
– ident: 42526_CR29
  doi: 10.3390/v12070784
– volume: 1953
  start-page: 3
  year: 2019
  ident: 42526_CR53
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-9145-7_1
– volume: 6
  start-page: e1001110
  year: 2010
  ident: 42526_CR19
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1001110
– volume: 6
  start-page: 828
  year: 2021
  ident: 42526_CR51
  publication-title: Nat. Microbiol.
  doi: 10.1038/s41564-021-00931-x
– volume: 31
  start-page: 1947
  year: 2012
  ident: 42526_CR41
  publication-title: EMBO J.
  doi: 10.1038/emboj.2012.53
– volume: 8
  start-page: 2281
  year: 2013
  ident: 42526_CR57
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.143
– volume: 7
  start-page: e1001258
  year: 2011
  ident: 42526_CR16
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1001258
– volume: 82
  start-page: 7677
  year: 2008
  ident: 42526_CR48
  publication-title: J. Virol.
  doi: 10.1128/JVI.00560-08
– volume: 83
  start-page: 10176
  year: 2009
  ident: 42526_CR45
  publication-title: J. Virol.
  doi: 10.1128/JVI.00422-09
– volume: 9
  start-page: 671
  year: 2012
  ident: 42526_CR59
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2089
– ident: 42526_CR55
  doi: 10.26508/lsa.202302005
– volume: 9
  start-page: e1003772
  year: 2013
  ident: 42526_CR9
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1003772
– volume: 80
  start-page: 4174
  year: 2006
  ident: 42526_CR46
  publication-title: J. Virol.
  doi: 10.1128/JVI.80.8.4174-4178.2006
– volume: 10
  year: 2019
  ident: 42526_CR12
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-08135-4
– volume: 129
  start-page: 329
  year: 2016
  ident: 42526_CR25
  publication-title: J. Cell Sci.
– volume: 370
  start-page: 241
  year: 2020
  ident: 42526_CR50
  publication-title: Science
  doi: 10.1126/science.abb3753
– volume: 87
  start-page: 1691
  year: 2006
  ident: 42526_CR37
  publication-title: J. Gen. Virol.
  doi: 10.1099/vir.0.81749-0
– volume: 565
  start-page: 505
  year: 2019
  ident: 42526_CR23
  publication-title: Nature
  doi: 10.1038/s41586-018-0858-8
– volume: 23
  start-page: 3
  year: 2022
  ident: 42526_CR35
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-021-00418-x
– volume: 15
  start-page: 483
  year: 2017
  ident: 42526_CR39
  publication-title: Expert Rev. Anti Infect. Ther.
  doi: 10.1080/14787210.2017.1305888
– volume: 2
  start-page: 8
  year: 2022
  ident: 42526_CR40
  publication-title: Nat. Rev. Methods Prim.
  doi: 10.1038/s43586-021-00093-4
– volume: 78
  start-page: 5458
  year: 2004
  ident: 42526_CR15
  publication-title: J. Virol.
  doi: 10.1128/JVI.78.10.5458-5465.2004
SSID ssj0000391844
Score 2.4801948
Snippet Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors...
Abstract Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 6785
SubjectTerms 13/1
13/100
13/31
14/19
631/326/596/2041
631/326/596/2042
631/326/596/2557
631/326/596/4130
82/29
Animals
Blood vessels
Cell lines
Cell migration
Ebola virus
Ebolavirus
Ebolavirus - metabolism
Endocytosis
Endosomes
Filoviridae
Guanine nucleotide exchange factor
Guanine Nucleotide Exchange Factors - metabolism
Hemorrhagic Fever, Ebola
Humanities and Social Sciences
Humans
Infections
Lysosomes
Marburg Virus Disease - genetics
Marburg Virus Disease - metabolism
Marburgvirus
Marburgvirus - metabolism
multidisciplinary
Nucleotides
Organoids
Protein transport
Receptors
Science
Science (multidisciplinary)
Screening
Severe acute respiratory syndrome coronavirus 2
Therapeutic targets
Trafficking
Tropism
Vesicular Transport Proteins - metabolism
Viral diseases
Viruses
SummonAdditionalLinks – databaseName: Biological Science Database
  dbid: M7P
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Jb9QwFLaggMSFfQkUZCRuEDWxHS8nBKNWHKDqAVDFxfIStyMNSUlmKvXf8-ws1bD0wi2KbcnOe89vzfcQel0FQUkoArgl3OasKopcWS9ya70xlhNrUjHmt0_i8FAeH6ujMeDWj2WV052YLmrfuhgj3yNSgrYHcSjfnf3MY9eomF0dW2hcRzciSgJNpXtHc4wlop9LxsZ_ZQoq93qWbgZQVDkwK-E539JHCbb_b7bmnyWTv-VNkzo6uPu_B7mH7oyGKH4_cM59dK1uHqBbQ2vKi4doNfzBG8aQHm4DXiy-l9j02DQ4Ao7DKKxfXfRt3_6AJ9hwhKOIoXfcDR3u2w4vG_zZRMqdwDqP9y240vh82W16PNWBNf0j9PVg_8viYz52ZshdJdQ6h6_qI3SRI0IYDi5TLRWTtAhwKs4UE45SR50nPLiq9KUHS8E6FQqnqspKQh-jnaZt6qcI1z5Iw6lQNQPrEhxmroLhvC58LbzxLEPlRB_tRtjy2D1jpVP6nEo90FQDTXWiqeYZejOvORtAO66c_SGSfZ4ZAbfTi7Y70aP86pJKR1zpjOeOyapW1gRTEqtcZXyoXIZ2J2rr8Rbo9SWpM_RqHgb5jUkZ09TtJs0BoxbMMpmhJwOPzTuJWP9gQ4kMyS3u29rq9kizPE0Y4eDppyRzht5OjHq5r39_i2dXH-M5uk2i7IDuJtUu2ll3m_oFuunO18u-e5mE7xcQtDbe
  priority: 102
  providerName: ProQuest
Title Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections
URI https://link.springer.com/article/10.1038/s41467-023-42526-6
https://www.ncbi.nlm.nih.gov/pubmed/37880247
https://www.proquest.com/docview/2881543761
https://www.proquest.com/docview/2882321908
https://pubmed.ncbi.nlm.nih.gov/PMC10600203
https://doaj.org/article/138c2c1cad6c485e9bafa12b9c5adf5c
Volume 14
WOSCitedRecordID wos001096436800015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: DOA
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources (selected full-text only)
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M~E
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Advanced Technologies & Aerospace Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: P5Z
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/hightechjournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M7P
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection (ProQuest)
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: 7X7
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: BENPR
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Publicly Available Content Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: PIMPY
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEA96Kvgifls9lwi-abk2ab4evWUPBW8porLeS8lHowtrK-3uwf33TtLueuvniy-lNAkdZiaZmWTyG4SeMy8o8ZmHsISbtGBZlirjRGqM09pwYnRMxvz4VszncrFQ5aVSXyEnbIAHHhh3lFNpic2tdtwWktXKaK9zYpRl2nlmw-oLXs-lYCquwVRB6FKMt2QyKo_6Iq4JYKJSUFPCU75niSJg_--8zF-TJX86MY2G6OQ2ujV6kPjVQPkddKVu7qIbQ03Ji3toNVy99eNeHG49nk7Pcqx7rBsckMKhFcavLvq2b7_CG_wv4EiEPXPcDaXp2w4vG3yqA8s_wziHZwZiYHy-7DY93iZwNf199OFk9n76Oh1LKqSWCbVOgSkuYA5ZIoTmEOvUUhWSZl6ArApVCEuppdYR7i3LXe7AxBurfGYVY0YS-gAdNG1TP0K4dl5qToWqC3ALIdLlymvO68zVwmlXJCjfsreyI954KHuxquK5N5XVIJIKRFJFkVQ8QS92Y74NaBt_7X0cpLbrGZCy4wfQn2rUn-pf-pOgw63Mq3H69hWRElxLWHvzBD3bNcPEC6cpuqnbTewD3ij4UzJBDwcV2VESQPrB-REJknvKs0fqfkuz_BLBvSFEj6fDCXq51bMfdP2ZF4__By-eoJskTBAwzYQdooN1t6mfouv2fL3suwm6KhYiPuUEXTuezct3kzjrJiFhtoRnyc6gpXxzWn76Don7MbA
linkProvider Directory of Open Access Journals
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELaqAoILb2iggJHgBFETO3GcA0KwtGrV7aqHgiouruPHstI2Kclu0f4pfiNjJ9lqefTWA7dobUeO95uZz57xDEKvUptRYiML2xJWhEkaRWFe6CwsCi1lwUghfTDml2E2GvHj4_xwDf3s78K4sMpeJ3pFrSvlzsi3COdg7UEc4vdn30NXNcp5V_sSGi0s9s3iB2zZmnd7n-D_fU3IzvbRYDfsqgqEKs3yWQhbGu3S7iiSZZIB3Tc8TziNLLyaJXmSKUoVVZowq9JYxxqsXKFyG6k8TQvuEh2Ayr8GNIJwHyp4uDzTcdnWeZJ0d3MiyreaxGsiMIwhCAdhIVuxf75MwN-47Z8hmr_5ab3527nzvy3cXXS7I9r4QysZ99CaKe-jG23pzcUDNG1vKNvuyBJXFg8GX2MsGyxL7BKqQyuMny6aqqlO4QkWyKXbcK4FXJuxK3tW1XhS4gPpkDmGcRpvF9VU4vNJPW9wH-dWNg_R5yv51EdovaxKs4Gw0ZZLRrPcJMCeKeUst5IxE2mTaamTAMU9HoTq0rK76iBT4cMDKBcthgRgSHgMCRagN8sxZ21Skkt7f3QwW_Z0CcX9D1U9Fp1-EjHliqhYSc1UwlOTF9LKmBS5SqW2qQrQZo8u0Wm5RlxAK0Avl82gn5zTSZammvs-QNqBdvIAPW4xvZyJq2UAHDELEF9B-8pUV1vKyTefAz2OmHeiB-htLxgX8_r3Wjy5_DNeoJu7RwdDMdwb7T9Ft4iTW-ApJN1E67N6bp6h6-p8Nmnq517wMTq5aoH5Bft3kJA
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLamcREv3C-BAUaCJ4iaOIljPyAE3SqmjaoPgCZeMl9LpZKMpB3qX-PXcewkncplb3vgLaptxXG_c7HP8XcQep7ZPCE2srAtoTJMsygKudR5KKUWQlIihU_G_HyYj8fs6IhPttDP_i6MS6vsdaJX1LpS7ox8QBgDaw_iEA9slxYx2R29OfkeugpSLtLal9NoIXJgVj9g-9a83t-F__oFIaO9j8P3YVdhIFRZzhchbG-0o-BRJM8FBdffMJ6yJLLwGpryNFdJohKlCbUqi3WsweJJxW2keJZJ5kgPQP1fyh1puU8bnKzPdxzzOkvT7p5OlLBBk3qtBEYyBEEhNKQbttCXDPibn_tnuuZvMVtvCkc3_udFvImudw44fttKzC20Zcrb6EpbknN1B83bm8u2O8rElcXD4ZcYiwaLEjuidWiF8fNVUzXVN3iCxXI0HC7kgGszdeXQqhrPSvxBOMROYZzGe7KaC3w6q5cN7vPfyuYu-nQhn3oPbZdVaR4gbLRlgiY5Nyl41UnCKLeCUhNpk2uh0wDFPTYK1dG1u6oh88KnDSSsaPFUAJ4Kj6eCBujlesxJS1Zybu93DnLrno5o3P9Q1dOi01tFnDBFVKyEpiplmeFSWBETyVUmtM1UgHZ6pBWd9muKM5gF6Nm6GfSWC0aJ0lRL3weceXBHWYDut_hez8TVOADfMQ8Q20D-xlQ3W8rZV8-NHkfUB9cD9KoXkrN5_XstHp7_GU_RVZCT4nB_fPAIXSNOhMF9IdkO2l7US_MYXVani1lTP_E6AKPji5aXX7E_mU0
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+of+CCZ1+as+an+essential+lysosomal+trafficking+regulator+in+Marburg+and+Ebola+virus+infections&rft.jtitle=Nature+communications&rft.au=Monteil%2C+Vanessa&rft.au=Kwon%2C+Hyesoo&rft.au=John%2C+Lijo&rft.au=Salata%2C+Cristiano&rft.date=2023-10-25&rft.eissn=2041-1723&rft.volume=14&rft.issue=1&rft.spage=6785&rft_id=info:doi/10.1038%2Fs41467-023-42526-6&rft_id=info%3Apmid%2F37880247&rft.externalDocID=37880247
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon