Genetically engineered mouse models in oncology research and cancer medicine

Genetically engineered mouse models (GEMMs) have contributed significantly to the field of cancer research. In contrast to cancer cell inoculation models, GEMMs develop de novo tumors in a natural immune‐proficient microenvironment. Tumors arising in advanced GEMMs closely mimic the histopathologica...

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Veröffentlicht in:	EMBO molecular medicine Jg. 9; H. 2; S. 137 - 153
Hauptverfasser:	Kersten, Kelly, de Visser, Karin E, van Miltenburg, Martine H, Jonkers, Jos
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.02.2017 EMBO Press John Wiley and Sons Inc Springer Nature
Schlagworte:	Animal models Animals Animals, Genetically Modified Biology Cancer Cancer therapies Cell adhesion & migration Cell culture Clinical trials CRISPR Disease Models, Animal Drug resistance EMBO03 Extracellular matrix Fibroblasts Genes Genetic engineering genetically engineered mouse models Genomes Genomics Grants Humans Immune system Immunotherapy Inoculation Laboratories Medical Oncology - methods Medical research Metastases Metastasis Mice Mutation Neoplasms - pathology Neoplasms - therapy Oncology Patients Review Rodents Stem cells Therapeutic applications therapy tumor microenvironment Tumors Netherlands cancer genetically engineered mouse models tumor microenvironment metastasis therapy
ISSN:	1757-4676, 1757-4684
Online-Zugang:	Volltext
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