Long non-coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation

Transition from proliferative-to-invasive phenotypes promotes metastasis and therapy resistance in melanoma. Reversion of the invasive phenotype, however, is challenged by the poor understanding of mechanisms underlying its maintenance. Here, we report that the lncRNA TINCR is down-regulated in meta...

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Vydáno v:	EMBO reports Ročník 22; číslo 3; s. e50852 - n/a
Hlavní autoři:	Melixetian, Marine, Bossi, Daniela, Mihailovich, Marija, Punzi, Simona, Barozzi, Iros, Marocchi, Federica, Cuomo, Alessandro, Bonaldi, Tiziana, Testa, Giuseppe, Marine, Jean-Christophe, Leucci, Eleonora, Minucci, Saverio, Pelicci, Pier Giuseppe, Lanfrancone, Luisa
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 03.03.2021 Springer Nature B.V John Wiley and Sons Inc
Témata:	ATF4 Binding Depletion Drug resistance EMBO03 EMBO36 EMBO37 Genotype & phenotype integrated stress response lncRNAs MEK inhibitors Melanoma Metastases Metastasis Non-coding RNA Nutrients Phenotypes Phosphorylation Protein biosynthesis Protein synthesis Proteins Reversion Ribonucleic acid Ribosomes RNA Translation translational reprogramming Tumors lncRNAs melanoma translational reprogramming ATF4 integrated stress response
ISSN:	1469-221X, 1469-3178, 1469-3178
On-line přístup:	Získat plný text
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