Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer

Molecularly targeted therapies for advanced prostate cancer include castration modalities that suppress ligand-dependent transcriptional activity of the androgen receptor (AR). However, persistent AR signalling undermines therapeutic efficacy and promotes progression to lethal castration-resistant p...

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Veröffentlicht in:	Nature communications Jg. 7; H. 1; S. 13668
Hauptverfasser:	Henzler, Christine, Li, Yingming, Yang, Rendong, McBride, Terri, Ho, Yeung, Sprenger, Cynthia, Liu, Gang, Coleman, Ilsa, Lakely, Bryce, Li, Rui, Ma, Shihong, Landman, Sean R., Kumar, Vipin, Hwang, Tae Hyun, Raj, Ganesh V., Higano, Celestia S., Morrissey, Colm, Nelson, Peter S., Plymate, Stephen R., Dehm, Scott M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 29.11.2016 Nature Publishing Group Nature Portfolio
Schlagworte:	38 38/39 38/91 631/208/514/2256 631/208/69 692/4028/67/589/466 Alleles Androgens Cell Line, Tumor Chromosomes, Human, Pair 11 - genetics Clone Cells Exons - genetics Gene Dosage Gene Expression Regulation, Neoplastic Gene Rearrangement - genetics Genome, Human Geriatrics Heterogeneity Humanities and Social Sciences Humans Ligands Male Medical research multidisciplinary Mutation Neoplasm Metastasis Prostate cancer Prostatic Neoplasms, Castration-Resistant - genetics Receptors, Androgen - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Tumors Urology United States > US Texas Minnesota
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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