Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive molecular profiling of circulating metabolites captures highly heritable traits, which can help to uncover metabolic pathophysiology un...

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Published in:	Nature communications Vol. 7; no. 1; pp. 11122 - 9
Main Authors:	Kettunen, Johannes, Demirkan, Ayşe, Würtz, Peter, Draisma, Harmen H.M., Haller, Toomas, Rawal, Rajesh, Vaarhorst, Anika, Kangas, Antti J., Lyytikäinen, Leo-Pekka, Pirinen, Matti, Pool, René, Sarin, Antti-Pekka, Soininen, Pasi, Tukiainen, Taru, Wang, Qin, Tiainen, Mika, Tynkkynen, Tuulia, Amin, Najaf, Zeller, Tanja, Beekman, Marian, Deelen, Joris, van Dijk, Ko Willems, Esko, Tõnu, Hottenga, Jouke-Jan, van Leeuwen, Elisabeth M, Lehtimäki, Terho, Mihailov, Evelin, Rose, Richard J., de Craen, Anton J.M., Gieger, Christian, Kähönen, Mika, Perola, Markus, Blankenberg, Stefan, Savolainen, Markku J., Verhoeven, Aswin, Viikari, Jorma, Willemsen, Gonneke, Boomsma, Dorret I., van Duijn, Cornelia M., Eriksson, Johan, Jula, Antti, Järvelin, Marjo-Riitta, Kaprio, Jaakko, Metspalu, Andres, Raitakari, Olli, Salomaa, Veikko, Slagboom, P. Eline, Waldenberger, Melanie, Ripatti, Samuli, Ala-Korpela, Mika
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.03.2016 Nature Publishing Group Nature Portfolio
Subjects:	631/208/1516 631/208/205/2138 631/45/320 Adult Aged Amino acids Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Chromosome Mapping Female Genetic Predisposition to Disease Genome-Wide Association Study Health risks Humanities and Social Sciences Humans Lipoprotein(a) - genetics Lipoproteins, VLDL - metabolism Magnetic Resonance Spectroscopy Male Mendelian Randomization Analysis Metabolites Metabolomics - methods Middle Aged multidisciplinary NMR Nuclear magnetic resonance Science Science (multidisciplinary) Triglycerides - metabolism Young Adult
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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