Reprogramming of the circadian clock by nutritional challenge

Circadian rhythms and cellular metabolism are intimately linked. Here, we reveal that a high-fat diet (HFD) generates a profound reorganization of specific metabolic pathways, leading to widespread remodeling of the liver clock. Strikingly, in addition to disrupting the normal circadian cycle, HFD c...

Full description

Bibliographic Details

Published in:	Cell Vol. 155; no. 7; p. 1464
Main Authors:	Eckel-Mahan, Kristin L, Patel, Vishal R, de Mateo, Sara, Orozco-Solis, Ricardo, Ceglia, Nicholas J, Sahar, Saurabh, Dilag-Penilla, Sherry A, Dyar, Kenneth A, Baldi, Pierre, Sassone-Corsi, Paolo
Format:	Journal Article
Language:	English
Published:	United States 19.12.2013
Subjects:	Animals ARNTL Transcription Factors - metabolism Circadian Clocks Circadian Rhythm CLOCK Proteins - metabolism Diet, High-Fat Gene Expression Regulation Male Metabolic Networks and Pathways Mice Mice, Inbred C57BL Obesity - metabolism PPAR gamma - metabolism Transcriptome
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!