Reprogramming of the circadian clock by nutritional challenge

Circadian rhythms and cellular metabolism are intimately linked. Here, we reveal that a high-fat diet (HFD) generates a profound reorganization of specific metabolic pathways, leading to widespread remodeling of the liver clock. Strikingly, in addition to disrupting the normal circadian cycle, HFD c...

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Veröffentlicht in:	Cell Jg. 155; H. 7; S. 1464
Hauptverfasser:	Eckel-Mahan, Kristin L, Patel, Vishal R, de Mateo, Sara, Orozco-Solis, Ricardo, Ceglia, Nicholas J, Sahar, Saurabh, Dilag-Penilla, Sherry A, Dyar, Kenneth A, Baldi, Pierre, Sassone-Corsi, Paolo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 19.12.2013
Schlagworte:	Animals ARNTL Transcription Factors - metabolism Circadian Clocks Circadian Rhythm CLOCK Proteins - metabolism Diet, High-Fat Gene Expression Regulation Male Metabolic Networks and Pathways Mice Mice, Inbred C57BL Obesity - metabolism PPAR gamma - metabolism Transcriptome
ISSN:	1097-4172, 1097-4172
Online-Zugang:	Weitere Angaben
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