Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration

In vertebrates, activation of innate immunity is an early response to injury, implicating it in the regenerative process. However, the mechanisms by which innate signals might regulate stem cell functionality are unknown. Here, we demonstrate that type 2 innate immunity is required for regeneration...

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Vydané v:	Cell Ročník 153; číslo 2; s. 376
Hlavní autori:	Heredia, Jose E, Mukundan, Lata, Chen, Francis M, Mueller, Alisa A, Deo, Rahul C, Locksley, Richard M, Rando, Thomas A, Chawla, Ajay
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 11.04.2013
Predmet:	Animals Cobra Cardiotoxin Proteins Eosinophils - physiology Immunity, Innate Interleukin-13 - genetics Interleukin-13 - metabolism Interleukin-4 - genetics Interleukin-4 - metabolism Mice Muscle Development Muscle, Skeletal - cytology Muscle, Skeletal - injuries Muscle, Skeletal - physiology Myeloid Cells - metabolism Receptors, Cell Surface - metabolism Regeneration Signal Transduction STAT6 Transcription Factor - metabolism
ISSN:	1097-4172, 1097-4172
On-line prístup:	Zistit podrobnosti o prístupe
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