Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder

Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating severe BP (BP-I). By analyzing actigraphy data obtained...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 6; p. E754
Main Authors:	Pagani, Lucia, St Clair, Patricia A, Teshiba, Terri M, Service, Susan K, Fears, Scott C, Araya, Carmen, Araya, Xinia, Bejarano, Julio, Ramirez, Margarita, Castrillón, Gabriel, Gomez-Makhinson, Juliana, Lopez, Maria C, Montoya, Gabriel, Montoya, Claudia P, Aldana, Ileana, Navarro, Linda, Freimer, Daniel G, Safaie, Brian, Keung, Lap-Woon, Greenspan, Kiefer, Chou, Katty, Escobar, Javier I, Ospina-Duque, Jorge, Kremeyer, Barbara, Ruiz-Linares, Andres, Cantor, Rita M, Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Reus, Victor I, Sabatti, Chiara, Bearden, Carrie E, Takahashi, Joseph S, Freimer, Nelson B
Format:	Journal Article
Language:	English
Published:	United States 09.02.2016
Subjects:	Actigraphy Bipolar Disorder - genetics Bipolar Disorder - physiopathology Chromosomes, Human, Pair 1 - genetics Circadian Rhythm Family Female Humans Inheritance Patterns - genetics Lod Score Male Middle Aged Pedigree Phenotype Quantitative Trait, Heritable Sleep bipolar disorder actigraphy behavior circadian rhythms endophenotypes
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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