Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging

Tissues and organs are composed of distinct cell types that must operate in concert to perform physiological functions. Efforts to create high-dimensional biomarker catalogs of these cells have been largely based on single-cell sequencing approaches, which lack the spatial context required to unders...

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Bibliographic Details
Published in:	Nature methods Vol. 19; no. 3; pp. 284 - 295
Main Authors:	Hickey, John W., Neumann, Elizabeth K., Radtke, Andrea J., Camarillo, Jeannie M., Beuschel, Rebecca T., Albanese, Alexandre, McDonough, Elizabeth, Hatler, Julia, Wiblin, Anne E., Fisher, Jeremy, Croteau, Josh, Small, Eliza C., Sood, Anup, Caprioli, Richard M., Angelo, R. Michael, Nolan, Garry P., Chung, Kwanghun, Hewitt, Stephen M., Germain, Ronald N., Spraggins, Jeffrey M., Lundberg, Emma, Snyder, Michael P., Kelleher, Neil L., Saka, Sinem K.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.03.2022 Nature Publishing Group
Subjects:	631/1647/2067 631/1647/245/2225 706/648/697 Antibodies antibody Bioinformatics Biological Microscopy Biological Techniques Biomarkers Biomedical and Life Sciences Biomedical Engineering/Biotechnology Cell Communication Cell interactions Cellular communication Cellular structure Diagnostic Imaging Imaging Life Sciences Multiplexing Organs Peptide mapping Perspective Protein composition Proteins Proteomics Robustness
ISSN:	1548-7091, 1548-7105, 1548-7105
Online Access:	Get full text
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