The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound state. How cells process trapped PARP1 remains unclear. Using wild-type and a trapping-deficient PARP1 mutant combined with rapid immunopreci...

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Veröffentlicht in:	Nature cell biology Jg. 24; H. 1; S. 62 - 73
Hauptverfasser:	Krastev, Dragomir B., Li, Shudong, Sun, Yilun, Wicks, Andrew J., Hoslett, Gwendoline, Weekes, Daniel, Badder, Luned M., Knight, Eleanor G., Marlow, Rebecca, Pardo, Mercedes Calvo, Yu, Lu, Talele, Tanaji T., Bartek, Jiri, Choudhary, Jyoti S., Pommier, Yves, Pettitt, Stephen J., Tutt, Andrew N. J., Ramadan, Kristijan, Lord, Christopher J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.01.2022 Nature Publishing Group
Schlagworte:	13/106 13/109 13/31 14/19 14/35 631/337/1427/2566 631/80/458/538 631/80/458/582 692/699/67/1059/602 82/1 82/58 82/80 Adenosine diphosphate Adenosine triphosphatase Anticancer properties Biomedical and Life Sciences Cancer Research Cell Biology Cell Line, Tumor Chromatin Chromatin - metabolism Cytotoxicity Developmental Biology Disulfiram Disulfiram - analogs & derivatives Disulfiram - pharmacology HCT116 Cells HeLa Cells Homologous recombination Homology Humans Immunoprecipitation Inhibitors Labeling Life Sciences Mass spectrometry Mass spectroscopy MCF-7 Cells Metabolites Neoplasms - drug therapy Nuclear Proteins - metabolism Organoids Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors Poly (ADP-Ribose) Polymerase-1 - metabolism Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly-ADP-Ribose Binding Proteins - metabolism Protein Inhibitors of Activated STAT - metabolism Recruitment Ribose Scientific imaging Spectroscopy Stem Cells SUMO protein Sumoylation Toxicity Transcription Factors - metabolism Trapping Tumors Ubiquitin Ubiquitin-protein ligase Ubiquitination Valosin Containing Protein - metabolism
ISSN:	1465-7392, 1476-4679, 1476-4679
Online-Zugang:	Volltext
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