Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan

Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank),...

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Veröffentlicht in:	Nature communications Jg. 7; H. 1; S. 11174 - 7
Hauptverfasser:	Joshi, Peter K., Fischer, Krista, Schraut, Katharina E., Campbell, Harry, Esko, Tõnu, Wilson, James F.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 31.03.2016 Nature Publishing Group Nature Portfolio
Schlagworte:	631/208/726/649 631/443/7 Adult Age Factors Aged Aged, 80 and over Apolipoproteins E - genetics Apolipoproteins E - physiology Cohort Studies Female Genome-Wide Association Study Genotype Humanities and Social Sciences Humans Life span Longevity - genetics Male Middle Aged multidisciplinary Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Proportional Hazards Models Receptors, Nicotinic - genetics Receptors, Nicotinic - physiology Science Science (multidisciplinary) Sex Factors United Kingdom
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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