Hypoxia and hypoxia-inducible factors in diabetes and its complications

Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and funct...

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Bibliographic Details
Published in:	Diabetologia Vol. 64; no. 4; pp. 709 - 716
Main Authors:	Catrina, Sergiu-Bogdan, Zheng, Xiaowei
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2021 Springer Nature B.V
Subjects:	Animals Apoptosis Regulatory Proteins - metabolism Basic Helix-Loop-Helix Transcription Factors - metabolism Blood Glucose - metabolism Cell Hypoxia Cellular Microenvironment Diabetes Diabetes Complications - drug therapy Diabetes Complications - metabolism Diabetes Complications - physiopathology Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Diabetic nephropathy Diabetic neuropathy Diabetic retinopathy Foot diseases Homeostasis Human Physiology Humans Hyperglycemia Hypoglycemic Agents - therapeutic use Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Hypoxia-inducible factors Insulin resistance Internal Medicine Leg ulcers Medicine Medicine & Public Health Metabolic Diseases Molecular Targeted Therapy Oxygen - metabolism Prolyl-Hydroxylase Inhibitors - therapeutic use Repressor Proteins - metabolism Review Signal Transduction Diabetic retinopathy Prolyl hydroxylase inhibitor Diabetes complications Hypoxia-inducible factor Diabetic nephropathy Hypoxia Insulin resistance Diabetes Review Diabetic foot ulcer
ISSN:	0012-186X, 1432-0428, 1432-0428
Online Access:	Get full text
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