Hypoxia and hypoxia-inducible factors in diabetes and its complications

Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and funct...

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Podrobná bibliografie
Vydáno v:	Diabetologia Ročník 64; číslo 4; s. 709 - 716
Hlavní autoři:	Catrina, Sergiu-Bogdan, Zheng, Xiaowei
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2021 Springer Nature B.V
Témata:	Animals Apoptosis Regulatory Proteins - metabolism Basic Helix-Loop-Helix Transcription Factors - metabolism Blood Glucose - metabolism Cell Hypoxia Cellular Microenvironment Diabetes Diabetes Complications - drug therapy Diabetes Complications - metabolism Diabetes Complications - physiopathology Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Diabetic nephropathy Diabetic neuropathy Diabetic retinopathy Foot diseases Homeostasis Human Physiology Humans Hyperglycemia Hypoglycemic Agents - therapeutic use Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Hypoxia-inducible factors Insulin resistance Internal Medicine Leg ulcers Medicine Medicine & Public Health Metabolic Diseases Molecular Targeted Therapy Oxygen - metabolism Prolyl-Hydroxylase Inhibitors - therapeutic use Repressor Proteins - metabolism Review Signal Transduction Diabetic retinopathy Prolyl hydroxylase inhibitor Diabetes complications Hypoxia-inducible factor Diabetic nephropathy Hypoxia Insulin resistance Diabetes Review Diabetic foot ulcer
ISSN:	0012-186X, 1432-0428, 1432-0428
On-line přístup:	Získat plný text
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Shrnutí:	Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and function due to hyperglycaemia and elevated fatty acid levels. In this review, we will summarise and discuss current findings about the regulation of HIF signalling in diabetes and the pathogenic roles of hypoxia and dysregulated HIF signalling in the development of diabetes and its complications. The therapeutic potential of targeting HIF signalling for the prevention and treatment of diabetes and related complications is also discussed. Graphical abstract
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0012-186X 1432-0428 1432-0428
DOI:	10.1007/s00125-021-05380-z