Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas

Biallelic inactivation of the NF2 gene occurs in the majority of schwannomas. This usually involves a combination of a point mutation or multiexon deletion, in conjunction with either a second point mutation or loss of heterozygosity (LOH). We have performed DNA sequence and dosage analysis of the N...

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Bibliographic Details
Published in:	Oncogene Vol. 29; no. 47; pp. 6216 - 6221
Main Authors:	Hadfield, K D, Smith, M J, Urquhart, J E, Wallace, A J, Bowers, N L, King, A T, Rutherford, S A, Trump, D, Newman, W G, Evans, D G
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.11.2010 Nature Publishing Group
Subjects:	631/208/68 692/699/67/1922 Acoustic neuroma Adolescent Adult Apoptosis Biological and medical sciences Cancer Cell Biology Cell division Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Child Chromosome 22 Chromosome Breakpoints Copy number Fundamental and applied biological sciences. Psychology Gene deletion Gene Dosage - genetics Gene mutations Genes, Neurofibromatosis 2 Genetic aspects Genetic disorders Genotype & phenotype Genotyping Health aspects Heterozygosity Homozygote Human Genetics Humans Hybridization Internal Medicine Loss of heterozygosity Loss of Heterozygosity - genetics Medical sciences Medicine Medicine & Public Health Mitosis - genetics Molecular and cellular biology Mutation Nervous system Neurilemmoma - genetics Neurofibromatoses - genetics Neurofibromatosis Neurofibromatosis 2 Neurofibromatosis 2 - genetics Neurofibromin 2 Neurological disorders Neurology Nucleotide sequence Oncology original-article Point mutation Polymorphism, Single Nucleotide - genetics Recombination Recombination, Genetic - genetics Risk factors Schwann cells Sequence analysis Single nucleotide polymorphisms Skin Neoplasms - genetics Tumors Tumors of the nervous system. Phacomatoses Vestibular system Young Adult United Kingdom mitotic recombination schwannomatosis vestibular schwannoma Nervous system diseases SMARCB1 Mitotic recombination Sporadic Neurinoma Loss of heterozygosity Benign neoplasm NF2 Carcinogenesis
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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