Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

The absence of effective therapeutics against Alzheimer’s disease (AD) is a result of the limited understanding of its multifaceted aetiology. Because of the lack of chemical tools to identify pathological factors, investigations into AD pathogenesis have also been insubstantial. Here we report chem...

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Bibliographic Details
Published in:	Nature communications Vol. 7; no. 1; p. 13115
Main Authors:	Beck, Michael W., Derrick, Jeffrey S., Kerr, Richard A., Oh, Shin Bi, Cho, Woo Jong, Lee, Shin Jung C., Ji, Yonghwan, Han, Jiyeon, Tehrani, Zahra Aliakbar, Suh, Nayoung, Kim, Sujeong, Larsen, Scott D., Kim, Kwang S., Lee, Joo-Yong, Ruotolo, Brandon T., Lim, Mi Hee
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.10.2016 Nature Publishing Group Nature Portfolio
Subjects:	119/118 13/106 140/131 639/638/11/296 639/638/92/613 639/638/92/96 82/29 Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Amyloid - antagonists & inhibitors Amyloid - metabolism Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Animals Chemistry Design Drug Design Free Radicals - antagonists & inhibitors Free Radicals - metabolism Humanities and Social Sciences Humans Ionization Life sciences Metals Metals - antagonists & inhibitors Metals - metabolism Mice, Inbred C57BL Mice, Transgenic Molecular Structure multidisciplinary Pathogenesis Pathology Permeability Protein Aggregates - drug effects Proteins Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Science Science (multidisciplinary) Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology South Korea Ann Arbor Michigan United States > US Michigan
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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