A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells

Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential for DNA replication do not exhibit sequence-specific DNA binding. Here we identify a replication-initiation determinant (RepID) protein that...

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Bibliographic Details
Published in:	Nature communications Vol. 7; no. 1; pp. 11748 - 14
Main Authors:	Zhang, Ya, Huang, Liang, Fu, Haiqing, Smith, Owen K., Lin, Chii Mei, Utani, Koichi, Rao, Mishal, Reinhold, William C., Redon, Christophe E., Ryan, Michael, Kim, RyangGuk, You, Yang, Hanna, Harlington, Boisclair, Yves, Long, Qiaoming, Aladjem, Mirit I.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.06.2016 Nature Publishing Group Nature Portfolio
Subjects:	13/31 13/95 14/19 631/337/151 631/45/612/1229 Animals Base Sequence Binding sites Cell cycle Cell growth Cell Line Deoxyribonucleic acid DNA DNA Replication DNA-Binding Proteins - metabolism Embryo, Mammalian - cytology Fibroblasts - metabolism Genetic Loci Genome Genomes Humanities and Social Sciences Humans Locus Control Region Mammals Mammals - metabolism Mice Models, Biological multidisciplinary Protein Binding Proteins Replication Origin Science Science (multidisciplinary) Site selection Yeast United States > US
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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