A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells
Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential for DNA replication do not exhibit sequence-specific DNA binding. Here we identify a replication-initiation determinant (RepID) protein that...
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| Veröffentlicht in: | Nature communications Jg. 7; H. 1; S. 11748 - 14 |
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| Abstract | Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential for DNA replication do not exhibit sequence-specific DNA binding. Here we identify a replication-initiation determinant (RepID) protein that binds a subset of replication-initiation sites. A large fraction of RepID-binding sites share a common G-rich motif and exhibit elevated replication initiation. RepID is required for initiation of DNA replication from RepID-bound replication origins, including the origin at the human beta-globin
(HBB)
locus. At
HBB
, RepID is involved in an interaction between the replication origin (Rep-P) and the locus control region. RepID-depleted murine embryonic fibroblasts exhibit abnormal replication fork progression and fewer replication-initiation events. These observations are consistent with a model, suggesting that RepID facilitates replication initiation at a distinct group of human replication origins.
Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins. |
|---|---|
| AbstractList | Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential for DNA replication do not exhibit sequence-specific DNA binding. Here we identify a replication-initiation determinant (RepID) protein that binds a subset of replication-initiation sites. A large fraction of RepID-binding sites share a common G-rich motif and exhibit elevated replication initiation. RepID is required for initiation of DNA replication from RepID-bound replication origins, including the origin at the human beta-globin (HBB) locus. At HBB, RepID is involved in an interaction between the replication origin (Rep-P) and the locus control region. RepID-depleted murine embryonic fibroblasts exhibit abnormal replication fork progression and fewer replication-initiation events. These observations are consistent with a model, suggesting that RepID facilitates replication initiation at a distinct group of human replication origins.Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential for DNA replication do not exhibit sequence-specific DNA binding. Here we identify a replication-initiation determinant (RepID) protein that binds a subset of replication-initiation sites. A large fraction of RepID-binding sites share a common G-rich motif and exhibit elevated replication initiation. RepID is required for initiation of DNA replication from RepID-bound replication origins, including the origin at the human beta-globin (HBB) locus. At HBB, RepID is involved in an interaction between the replication origin (Rep-P) and the locus control region. RepID-depleted murine embryonic fibroblasts exhibit abnormal replication fork progression and fewer replication-initiation events. These observations are consistent with a model, suggesting that RepID facilitates replication initiation at a distinct group of human replication origins. Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential for DNA replication do not exhibit sequence-specific DNA binding. Here we identify a replication-initiation determinant (RepID) protein that binds a subset of replication-initiation sites. A large fraction of RepID-binding sites share a common G-rich motif and exhibit elevated replication initiation. RepID is required for initiation of DNA replication from RepID-bound replication origins, including the origin at the human beta-globin (HBB) locus. At HBB , RepID is involved in an interaction between the replication origin (Rep-P) and the locus control region. RepID-depleted murine embryonic fibroblasts exhibit abnormal replication fork progression and fewer replication-initiation events. These observations are consistent with a model, suggesting that RepID facilitates replication initiation at a distinct group of human replication origins. Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential for DNA replication do not exhibit sequence-specific DNA binding. Here we identify a replication-initiation determinant (RepID) protein that binds a subset of replication-initiation sites. A large fraction of RepID-binding sites share a common G-rich motif and exhibit elevated replication initiation. RepID is required for initiation of DNA replication from RepID-bound replication origins, including the origin at the human beta-globin (HBB) locus. At HBB , RepID is involved in an interaction between the replication origin (Rep-P) and the locus control region. RepID-depleted murine embryonic fibroblasts exhibit abnormal replication fork progression and fewer replication-initiation events. These observations are consistent with a model, suggesting that RepID facilitates replication initiation at a distinct group of human replication origins. Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins. Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential for DNA replication do not exhibit sequence-specific DNA binding. Here we identify a replication-initiation determinant (RepID) protein that binds a subset of replication-initiation sites. A large fraction of RepID-binding sites share a common G-rich motif and exhibit elevated replication initiation. RepID is required for initiation of DNA replication from RepID-bound replication origins, including the origin at the human beta-globin (HBB) locus. At HBB, RepID is involved in an interaction between the replication origin (Rep-P) and the locus control region. RepID-depleted murine embryonic fibroblasts exhibit abnormal replication fork progression and fewer replication-initiation events. These observations are consistent with a model, suggesting that RepID facilitates replication initiation at a distinct group of human replication origins. Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins. Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential for DNA replication do not exhibit sequence-specific DNA binding. Here we identify a replication-initiation determinant (RepID) protein that binds a subset of replication-initiation sites. A large fraction of RepID-binding sites share a common G-rich motif and exhibit elevated replication initiation. RepID is required for initiation of DNA replication from RepID-bound replication origins, including the origin at the human beta-globin (HBB) locus. At HBB, RepID is involved in an interaction between the replication origin (Rep-P) and the locus control region. RepID-depleted murine embryonic fibroblasts exhibit abnormal replication fork progression and fewer replication-initiation events. These observations are consistent with a model, suggesting that RepID facilitates replication initiation at a distinct group of human replication origins. Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins. |
| ArticleNumber | 11748 |
| Author | Ryan, Michael Huang, Liang Hanna, Harlington Boisclair, Yves Kim, RyangGuk Rao, Mishal Reinhold, William C. Zhang, Ya Lin, Chii Mei Smith, Owen K. Redon, Christophe E. Fu, Haiqing Utani, Koichi Long, Qiaoming You, Yang Aladjem, Mirit I. |
| Author_xml | – sequence: 1 givenname: Ya surname: Zhang fullname: Zhang, Ya organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 2 givenname: Liang orcidid: 0000-0003-1663-7025 surname: Huang fullname: Huang, Liang organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 3 givenname: Haiqing surname: Fu fullname: Fu, Haiqing organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 4 givenname: Owen K. surname: Smith fullname: Smith, Owen K. organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 5 givenname: Chii Mei surname: Lin fullname: Lin, Chii Mei organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 6 givenname: Koichi surname: Utani fullname: Utani, Koichi organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 7 givenname: Mishal surname: Rao fullname: Rao, Mishal organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 8 givenname: William C. surname: Reinhold fullname: Reinhold, William C. organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 9 givenname: Christophe E. surname: Redon fullname: Redon, Christophe E. organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 10 givenname: Michael surname: Ryan fullname: Ryan, Michael organization: In Silico Solutions – sequence: 11 givenname: RyangGuk surname: Kim fullname: Kim, RyangGuk organization: In Silico Solutions – sequence: 12 givenname: Yang surname: You fullname: You, Yang organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 13 givenname: Harlington surname: Hanna fullname: Hanna, Harlington organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 14 givenname: Yves surname: Boisclair fullname: Boisclair, Yves organization: Department of Animal Science, Cornell University – sequence: 15 givenname: Qiaoming surname: Long fullname: Long, Qiaoming organization: Department of Animal Science, Cornell University – sequence: 16 givenname: Mirit I. surname: Aladjem fullname: Aladjem, Mirit I. email: aladjemm@mail.nih.gov organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27272143$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.molcel.2006.08.010 10.1038/366588a0 10.1101/gad.4.10.1637 10.1002/jcb.23117 10.4161/cc.2.4.435 10.1128/MCB.01290-09 10.7554/eLife.06496 10.1038/ncomms7746 10.1093/nar/29.3.809 10.1101/gad.1084203 10.1128/MCB.02278-06 10.1371/journal.pgen.1003542 10.1128/MCB.00710-09 10.1016/j.molcel.2011.06.036 10.1126/science.281.5379.1005 10.1128/MCB.8.11.4958 10.1016/j.tig.2011.10.003 10.1038/73439 10.1002/jcb.10298 10.1126/science.270.5237.815 10.1146/annurev.biochem.052308.103205 10.1002/bies.10370 10.1186/1471-2164-10-277 10.1038/nrm1663 10.1128/MCB.00232-08 10.1093/oxfordjournals.molbev.a026321 10.1371/journal.pgen.1004923 10.1038/nsmb.2339 10.1093/nar/gkq1276 10.1073/pnas.86.19.7470 10.1128/MCB.22.24.8426-8437.2002 10.1101/gr.121830.111 10.1038/nbt1202 10.1038/emboj.2010.204 10.1016/j.molcel.2011.06.021 10.1073/pnas.1119949109 10.1101/gr.124644.111 10.1128/MCB.05587-11 10.1007/s10577-009-9087-1 10.1016/j.febslet.2010.08.042 10.1074/jbc.C000611200 10.1016/j.ceb.2006.04.001 10.1038/nrg2143 10.1128/MCB.24.8.3373-3386.2004 10.1093/nar/gku072 10.1101/sqb.2010.75.011 10.1073/pnas.96.2.592 10.1016/j.jmb.2007.11.006 10.1101/gad.1913210 10.1073/pnas.85.21.8081 10.1002/(SICI)1521-1878(199901)21:1<5::AID-BIES2>3.0.CO;2-6 10.1038/nrm2976 10.1128/MCB.02409-06 10.1007/s10577-009-9105-3 10.1016/j.molcel.2011.08.028 10.1038/ng.810 10.1038/sj.emboj.7600077 10.1002/iub.129 10.1073/pnas.0805208105 10.1074/jbc.M111.222802 10.1093/emboj/20.21.6150 10.1016/j.tibs.2011.05.002 10.1002/ijc.2910190505 10.1101/gr.142331.112 |
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| References | Thangavel (CR21) 2010; 30 Scherf (CR64) 2000; 24 Shimura (CR63) 2008; 375 Vashee (CR12) 2003; 17 Wei (CR48) 2011; 43 Aladjem (CR49) 1995; 270 Chowdhury (CR20) 2010; 30 Cayrou (CR7) 2011; 21 Shankavaram (CR47) 2009; 10 Epner, Forrester, Groudine (CR39) 1988; 85 Simon (CR40) 2001; 20 Huang (CR46) 2011; 31 Podcheko (CR25) 2007; 27 Schepers, Papior (CR19) 2010; 18 Forrester (CR38) 1990; 4 Liu (CR58) 2011; 286 Blow, Ge, Jackson (CR60) 2011; 36 Francino, Ochman (CR43) 2000; 17 Wang (CR34) 2004; 24 Henning (CR32) 1999; 96 Kitsberg, Selig, Keshet, Cedar (CR33) 1993; 366 Bielinsky (CR2) 2003; 2 Markova, Kantidze, Razin (CR65) 2011; 112 Cadoret (CR51) 2008; 105 Jin, Arias, Chen, Harper, Walter (CR28) 2006; 23 Dhar, Mager, Iqbal, Schildkraut (CR36) 1988; 8 Raman, Havens, Walter, Harper (CR29) 2011; 44 Giri (CR22) 2015; 4 DePamphilis (CR56) 1999; 21 Remus, Beall, Botchan (CR13) 2004; 23 Mendez, Stillman (CR11) 2003; 25 Kamath, Leffak (CR41) 2001; 29 Gilbert (CR5) 2010; 75 Mechali (CR1) 2010; 11 Yun (CR54) 2014; 42 Donley, Smith, Thayer (CR57) 2015; 11 Farhang-Fallah, Yin, Trentin, Cheng, Rozakis-Adcock (CR24) 2000; 275 Dellino (CR16) 2013; 23 Driscoll, Dobkin, Alter (CR37) 1989; 86 Besnard (CR18) 2012; 19 McCall (CR59) 2008; 28 Fu (CR55) 2013; 9 Masai, Matsumoto, You, Yoshizawa-Sugata, Oda (CR10) 2010; 79 Debatisse, Le Tallec, Letessier, Dutrillaux, Brison (CR61) 2012; 28 Karmakar, Mahajan, Schulz, Boyapaty, Weissman (CR44) 2010; 29 Franz (CR30) 2011; 44 Jacob, Brenner (CR17) 1963; 256 Fu (CR35) 2006; 24 Seiler, Conti, Syed, Aladjem, Pommier (CR53) 2007; 27 Fu (CR62) 2015; 6 Cayrou, Coulombe, Mechali (CR52) 2010; 18 Lunyak, Ezrokhi, Smith, Gerbi (CR6) 2002; 22 Martin (CR4) 2011; 21 Lubelsky (CR15) 2011; 39 Eaton, Galani, Kang, Bell, MacAlpine (CR14) 2010; 24 Miotto, Struhl (CR23) 2011; 44 DePamphilis (CR8) 2006; 18 Aladjem, Rodewald, Kolman, Wahl (CR31) 1998; 281 Li (CR26) 2010; 584 Djeliova, Russev, Anachkova (CR42) 2002; 87 Noordermeer, de Laat (CR50) 2008; 60 Blow, Dutta (CR9) 2005; 6 De Semir (CR27) 2012; 109 Schneider, Schwenk, Bornkamm (CR45) 1977; 19 Aladjem (CR3) 2007; 8 H Masai (BFncomms11748_CR10) 2010; 79 MI Aladjem (BFncomms11748_CR31) 1998; 281 WC Forrester (BFncomms11748_CR38) 1990; 4 H Fu (BFncomms11748_CR55) 2013; 9 I Simon (BFncomms11748_CR40) 2001; 20 ML DePamphilis (BFncomms11748_CR8) 2006; 18 MI Aladjem (BFncomms11748_CR49) 1995; 270 E Epner (BFncomms11748_CR39) 1988; 85 N Donley (BFncomms11748_CR57) 2015; 11 M Mechali (BFncomms11748_CR1) 2010; 11 A Podcheko (BFncomms11748_CR25) 2007; 27 H Fu (BFncomms11748_CR62) 2015; 6 M Raman (BFncomms11748_CR29) 2011; 44 F Jacob (BFncomms11748_CR17) 1963; 256 U Schneider (BFncomms11748_CR45) 1977; 19 J Farhang-Fallah (BFncomms11748_CR24) 2000; 275 S Vashee (BFncomms11748_CR12) 2003; 17 ML Eaton (BFncomms11748_CR14) 2010; 24 S Li (BFncomms11748_CR26) 2010; 584 V Dhar (BFncomms11748_CR36) 1988; 8 UT Shankavaram (BFncomms11748_CR47) 2009; 10 M Debatisse (BFncomms11748_CR61) 2012; 28 S Thangavel (BFncomms11748_CR21) 2010; 30 L Wang (BFncomms11748_CR34) 2004; 24 AK Bielinsky (BFncomms11748_CR2) 2003; 2 A Franz (BFncomms11748_CR30) 2011; 44 WJ Yun (BFncomms11748_CR54) 2014; 42 Y Lubelsky (BFncomms11748_CR15) 2011; 39 JC Cadoret (BFncomms11748_CR51) 2008; 105 V Djeliova (BFncomms11748_CR42) 2002; 87 X Wei (BFncomms11748_CR48) 2011; 43 S Liu (BFncomms11748_CR58) 2011; 286 DM Gilbert (BFncomms11748_CR5) 2010; 75 E Besnard (BFncomms11748_CR18) 2012; 19 D Noordermeer (BFncomms11748_CR50) 2008; 60 ML DePamphilis (BFncomms11748_CR56) 1999; 21 T Shimura (BFncomms11748_CR63) 2008; 375 U Scherf (BFncomms11748_CR64) 2000; 24 J Mendez (BFncomms11748_CR11) 2003; 25 A Schepers (BFncomms11748_CR19) 2010; 18 C Cayrou (BFncomms11748_CR52) 2010; 18 A Chowdhury (BFncomms11748_CR20) 2010; 30 MP Francino (BFncomms11748_CR43) 2000; 17 JJ Blow (BFncomms11748_CR9) 2005; 6 JA Seiler (BFncomms11748_CR53) 2007; 27 S Giri (BFncomms11748_CR22) 2015; 4 B Miotto (BFncomms11748_CR23) 2011; 44 KA Henning (BFncomms11748_CR32) 1999; 96 L Huang (BFncomms11748_CR46) 2011; 31 MC Driscoll (BFncomms11748_CR37) 1989; 86 D Remus (BFncomms11748_CR13) 2004; 23 D Kitsberg (BFncomms11748_CR33) 1993; 366 S Kamath (BFncomms11748_CR41) 2001; 29 S Karmakar (BFncomms11748_CR44) 2010; 29 EN Markova (BFncomms11748_CR65) 2011; 112 MM Martin (BFncomms11748_CR4) 2011; 21 MI Aladjem (BFncomms11748_CR3) 2007; 8 C Cayrou (BFncomms11748_CR7) 2011; 21 GI Dellino (BFncomms11748_CR16) 2013; 23 H Fu (BFncomms11748_CR35) 2006; 24 D De Semir (BFncomms11748_CR27) 2012; 109 CM McCall (BFncomms11748_CR59) 2008; 28 JJ Blow (BFncomms11748_CR60) 2011; 36 J Jin (BFncomms11748_CR28) 2006; 23 VV Lunyak (BFncomms11748_CR6) 2002; 22 23754963 - PLoS Genet. 2013 Jun;9(6):e1003542 20066560 - Chromosome Res. 2010 Jan;18(1):137-45 17636024 - Mol Cell Biol. 2007 Sep;27(18):6484-96 11689454 - EMBO J. 2001 Nov 1;20(21):6150-7 12397609 - J Cell Biochem. 2002;87(3):279-83 18838675 - Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15837-42 16949367 - Mol Cell. 2006 Sep 1;23 (5):709-21 68013 - Int J Cancer. 1977 May 15;19(5):621-6 12851480 - Cell Cycle. 2003 Jul-Aug;2(4):307-9 9703500 - Science. 1998 Aug 14;281(5379):1005-9 20065034 - Mol Cell Biol. 2010 Mar;30(6):1495-507 21499247 - Nat Genet. 2011 May;43(5):442-6 10070250 - Bioessays. 1999 Jan;21(1):5-16 21139067 - Cold Spring Harb Symp Quant Biol. 2010;75:143-53 21856198 - Mol Cell. 2011 Oct 7;44(1):62-71 21148149 - Nucleic Acids Res. 2011 Apr;39(8):3141-55 16604060 - Nat Biotechnol. 2006 May;24(5):572-6 2798417 - Proc Natl Acad Sci U S A. 1989 Oct;86(19):7470-4 25922909 - Elife. 2015 Apr 29;4:null 25569254 - PLoS Genet. 2015 Jan 08;11(1):e1004923 22751019 - Nat Struct Mol Biol. 2012 Aug;19(8):837-44 15928711 - Nat Rev Mol Cell Biol. 2005 Jun;6(6):476-86 2850471 - Mol Cell Biol. 1988 Nov;8(11):4958-65 3186709 - Proc Natl Acad Sci U S A. 1988 Nov;85(21):8081-5 15060158 - Mol Cell Biol. 2004 Apr;24(8):3373-86 14635251 - Bioessays. 2003 Dec;25(12):1158-67 21690294 - Mol Cell Biol. 2011 Aug;31(16):3472-84 20351051 - Genes Dev. 2010 Apr 15;24(8):748-53 8255298 - Nature. 1993 Dec 9;366(6455):588-90 25879486 - Nat Commun. 2015 Apr 16;6:6746 7481774 - Science. 1995 Nov 3;270(5237):815-9 14765124 - EMBO J. 2004 Feb 25;23(4):897-907 13964280 - C R Hebd Seances Acad Sci. 1963 Jan 2;256:298-300 20861881 - Nat Rev Mol Cell Biol. 2010 Oct;11(10):728-38 22511720 - Proc Natl Acad Sci U S A. 2012 May 1;109(18):7067-72 19549304 - BMC Genomics. 2009 Jun 23;10:277 12897055 - Genes Dev. 2003 Aug 1;17(15):1894-908 18054789 - J Mol Biol. 2008 Jan 25;375(4):1152-64 19904620 - Chromosome Res. 2010 Jan;18(1):63-77 21981919 - Mol Cell. 2011 Oct 7;44(1):72-84 10700175 - Nat Genet. 2000 Mar;24(3):236-44 22094264 - Trends Genet. 2012 Jan;28(1):22-32 10723742 - Mol Biol Evol. 2000 Mar;17(3):416-22 11160905 - Nucleic Acids Res. 2001 Feb 1;29(3):809-17 18606781 - Mol Cell Biol. 2008 Sep;28(18):5621-33 21750104 - Genome Res. 2011 Sep;21(9):1438-49 20065033 - Mol Cell Biol. 2010 Mar;30(6):1382-96 20816727 - FEBS Lett. 2010 Sep 24;584(18):4121-7 21981920 - Mol Cell. 2011 Oct 7;44(1):85-96 17515603 - Mol Cell Biol. 2007 Aug;27(16):5806-18 21445863 - J Cell Biochem. 2011 Aug;112(8):1997-2005 20808282 - EMBO J. 2010 Oct 6;29(19):3260-71 9892678 - Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):592-7 11018022 - J Biol Chem. 2000 Dec 22;275(51):40492-7 12446763 - Mol Cell Biol. 2002 Dec;22(24):8426-37 16650748 - Curr Opin Cell Biol. 2006 Jun;18(3):231-9 21558276 - J Biol Chem. 2011 Jun 24;286(25):22314-22 24470145 - Nucleic Acids Res. 2014 Apr;42(7):4283-93 20373915 - Annu Rev Biochem. 2010;79:89-130 23187890 - Genome Res. 2013 Jan;23(1):1-11 2249769 - Genes Dev. 1990 Oct;4(10):1637-49 17621316 - Nat Rev Genet. 2007 Aug;8(8):588-600 18767169 - IUBMB Life. 2008 Dec;60(12):824-33 21813623 - Genome Res. 2011 Nov;21(11):1822-32 21641805 - Trends Biochem Sci. 2011 Aug;36(8):405-14 |
| References_xml | – volume: 23 start-page: 709 year: 2006 end-page: 721 ident: CR28 article-title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1 publication-title: Mol. Cell doi: 10.1016/j.molcel.2006.08.010 – volume: 366 start-page: 588 year: 1993 end-page: 590 ident: CR33 article-title: Replication structure of the human beta-globin gene domain publication-title: Nature doi: 10.1038/366588a0 – volume: 4 start-page: 1637 year: 1990 end-page: 1649 ident: CR38 article-title: A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus publication-title: Genes Dev. doi: 10.1101/gad.4.10.1637 – volume: 112 start-page: 1997 year: 2011 end-page: 2005 ident: CR65 article-title: Transcriptional regulation and spatial organisation of the human AML1/RUNX1 gene publication-title: J. Cell. Biochem. doi: 10.1002/jcb.23117 – volume: 2 start-page: 307 year: 2003 end-page: 309 ident: CR2 article-title: Replication origins: why do we need so many? publication-title: Cell Cycle doi: 10.4161/cc.2.4.435 – volume: 30 start-page: 1382 year: 2010 end-page: 1396 ident: CR21 article-title: Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation publication-title: Mol. Cell Biol. doi: 10.1128/MCB.01290-09 – volume: 4 start-page: e06496 year: 2015 ident: CR22 article-title: The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin publication-title: eLife doi: 10.7554/eLife.06496 – volume: 6 start-page: 6746 year: 2015 ident: CR62 article-title: The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage publication-title: Nat. Commun. doi: 10.1038/ncomms7746 – volume: 29 start-page: 809 year: 2001 end-page: 817 ident: CR41 article-title: Multiple sites of replication initiation in the human beta-globin gene locus publication-title: Nucleic Acids Res. doi: 10.1093/nar/29.3.809 – volume: 17 start-page: 1894 year: 2003 end-page: 1908 ident: CR12 article-title: Sequence-independent DNA binding and replication initiation by the human origin recognition complex publication-title: Genes Dev. doi: 10.1101/gad.1084203 – volume: 27 start-page: 5806 year: 2007 end-page: 5818 ident: CR53 article-title: The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses publication-title: Mol. Cell Biol. doi: 10.1128/MCB.02278-06 – volume: 9 start-page: e1003542 year: 2013 ident: CR55 article-title: Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1003542 – volume: 30 start-page: 1495 year: 2010 end-page: 1507 ident: CR20 article-title: The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation publication-title: Mol. Cell Biol. doi: 10.1128/MCB.00710-09 – volume: 44 start-page: 72 year: 2011 end-page: 84 ident: CR29 article-title: A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.06.036 – volume: 281 start-page: 1005 year: 1998 end-page: 1009 ident: CR31 article-title: Genetic dissection of a mammalian replicator in the human beta-globin locus publication-title: Science doi: 10.1126/science.281.5379.1005 – volume: 8 start-page: 4958 year: 1988 end-page: 4965 ident: CR36 article-title: The coordinate replication of the human beta-globin gene domain reflects its transcriptional activity and nuclease hypersensitivity publication-title: Mol. Cell Biol. doi: 10.1128/MCB.8.11.4958 – volume: 28 start-page: 22 year: 2012 end-page: 32 ident: CR61 article-title: Common fragile sites: mechanisms of instability revisited publication-title: Trends Genet. doi: 10.1016/j.tig.2011.10.003 – volume: 24 start-page: 236 year: 2000 end-page: 244 ident: CR64 article-title: A gene expression database for the molecular pharmacology of cancer publication-title: Nat. Genet. doi: 10.1038/73439 – volume: 87 start-page: 279 year: 2002 end-page: 283 ident: CR42 article-title: DNase I sensitive site in the core region of the human beta-globin origin of replication publication-title: J. Cell Biochem. doi: 10.1002/jcb.10298 – volume: 270 start-page: 815 year: 1995 end-page: 819 ident: CR49 article-title: Participation of the human beta-globin locus control region in initiation of DNA replication publication-title: Science doi: 10.1126/science.270.5237.815 – volume: 79 start-page: 89 year: 2010 end-page: 130 ident: CR10 article-title: Eukaryotic chromosome DNA replication: where, when, and how? publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.052308.103205 – volume: 25 start-page: 1158 year: 2003 end-page: 1167 ident: CR11 article-title: Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins publication-title: Bioessays doi: 10.1002/bies.10370 – volume: 10 start-page: 277 year: 2009 ident: CR47 article-title: CellMiner: a relational database and query tool for the NCI-60 cancer cell lines publication-title: BMC Genomics doi: 10.1186/1471-2164-10-277 – volume: 6 start-page: 476 year: 2005 end-page: 486 ident: CR9 article-title: Preventing re-replication of chromosomal DNA publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1663 – volume: 28 start-page: 5621 year: 2008 end-page: 5633 ident: CR59 article-title: Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development publication-title: Mol. Cell Biol. doi: 10.1128/MCB.00232-08 – volume: 17 start-page: 416 year: 2000 end-page: 422 ident: CR43 article-title: Strand symmetry around the beta-globin origin of replication in primates publication-title: Mol. Biol. Evol. doi: 10.1093/oxfordjournals.molbev.a026321 – volume: 11 start-page: e1004923 year: 2015 ident: CR57 article-title: ASAR15, a cis-acting locus that controls chromosome-wide replication timing and stability of human chromosome 15 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004923 – volume: 19 start-page: 837 year: 2012 end-page: 844 ident: CR18 article-title: Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.2339 – volume: 39 start-page: 3141 year: 2011 end-page: 3155 ident: CR15 article-title: Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq1276 – volume: 86 start-page: 7470 year: 1989 end-page: 7474 ident: CR37 article-title: Gamma delta beta-thalassemia due to a mutation deleting the 5' beta-globin gene activation-region hypersensitive sites publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.86.19.7470 – volume: 22 start-page: 8426 year: 2002 end-page: 8437 ident: CR6 article-title: Developmental changes in the Sciara II/9A initiation zone for DNA replication publication-title: Mol. Cell Biol. doi: 10.1128/MCB.22.24.8426-8437.2002 – volume: 21 start-page: 1438 year: 2011 end-page: 1449 ident: CR7 article-title: Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features publication-title: Genome Res. doi: 10.1101/gr.121830.111 – volume: 24 start-page: 572 year: 2006 end-page: 576 ident: CR35 article-title: Preventing gene silencing with human replicators publication-title: Nat. Biotechnol. doi: 10.1038/nbt1202 – volume: 29 start-page: 3260 year: 2010 end-page: 3271 ident: CR44 article-title: A multiprotein complex necessary for both transcription and DNA replication at the beta-globin locus publication-title: EMBO J. doi: 10.1038/emboj.2010.204 – volume: 44 start-page: 62 year: 2011 end-page: 71 ident: CR23 article-title: JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.06.021 – volume: 109 start-page: 7067 year: 2012 end-page: 7072 ident: CR27 article-title: Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1119949109 – volume: 21 start-page: 1822 year: 2011 end-page: 1832 ident: CR4 article-title: Genome-wide depletion of replication initiation events in highly transcribed regions publication-title: Genome Res. doi: 10.1101/gr.124644.111 – volume: 31 start-page: 3472 year: 2011 end-page: 3484 ident: CR46 article-title: Prevention of transcriptional silencing by a replicator-binding complex consisting of SWI/SNF, MeCP1, and hnRNP C1/C2 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.05587-11 – volume: 18 start-page: 63 year: 2010 end-page: 77 ident: CR19 article-title: Why are we where we are? Understanding replication origins and initiation sites in eukaryotes using ChIP-approaches publication-title: Chromosome Res. doi: 10.1007/s10577-009-9087-1 – volume: 584 start-page: 4121 year: 2010 end-page: 4127 ident: CR26 article-title: The full-length isoform of the mouse pleckstrin homology domain-interacting protein (PHIP) is required for postnatal growth publication-title: FEBS Lett. doi: 10.1016/j.febslet.2010.08.042 – volume: 275 start-page: 40492 year: 2000 end-page: 40497 ident: CR24 article-title: Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein publication-title: J. Biol. Chem. doi: 10.1074/jbc.C000611200 – volume: 18 start-page: 231 year: 2006 end-page: 239 ident: CR8 article-title: Regulating the licensing of DNA replication origins in metazoa publication-title: Curr. Opin. Cell. Biol. doi: 10.1016/j.ceb.2006.04.001 – volume: 8 start-page: 588 year: 2007 end-page: 600 ident: CR3 article-title: Replication in context: dynamic regulation of DNA replication patterns in metazoans publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2143 – volume: 24 start-page: 3373 year: 2004 end-page: 3386 ident: CR34 article-title: The human beta-globin replication initiation region consists of two modular independent replicators publication-title: Mol. Cell Biol. doi: 10.1128/MCB.24.8.3373-3386.2004 – volume: 42 start-page: 4283 year: 2014 end-page: 4293 ident: CR54 article-title: The hematopoietic regulator TAL1 is required for chromatin looping between the beta-globin LCR and human gamma-globin genes to activate transcription publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku072 – volume: 75 start-page: 143 year: 2010 end-page: 153 ident: CR5 article-title: Space and time in the nucleus: developmental control of replication timing and chromosome architecture publication-title: Cold Spring Harb. Symp. Quant. Biol. doi: 10.1101/sqb.2010.75.011 – volume: 96 start-page: 592 year: 1999 end-page: 597 ident: CR32 article-title: Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.96.2.592 – volume: 375 start-page: 1152 year: 2008 end-page: 1164 ident: CR63 article-title: Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2007.11.006 – volume: 24 start-page: 748 year: 2010 end-page: 753 ident: CR14 article-title: Conserved nucleosome positioning defines replication origins publication-title: Genes Dev. doi: 10.1101/gad.1913210 – volume: 85 start-page: 8081 year: 1988 end-page: 8085 ident: CR39 article-title: Asynchronous DNA replication within the human beta-globin gene locus publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.85.21.8081 – volume: 21 start-page: 5 year: 1999 end-page: 16 ident: CR56 article-title: Replication origins in metazoan chromosomes: fact or fiction? publication-title: Bioessays doi: 10.1002/(SICI)1521-1878(199901)21:1<5::AID-BIES2>3.0.CO;2-6 – volume: 11 start-page: 728 year: 2010 end-page: 738 ident: CR1 article-title: Eukaryotic DNA replication origins: many choices for appropriate answers publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2976 – volume: 27 start-page: 6484 year: 2007 end-page: 6496 ident: CR25 article-title: Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival publication-title: Mol. Cell Biol. doi: 10.1128/MCB.02409-06 – volume: 18 start-page: 137 year: 2010 end-page: 145 ident: CR52 article-title: Programming DNA replication origins and chromosome organization publication-title: Chromosome Res. doi: 10.1007/s10577-009-9105-3 – volume: 256 start-page: 298 year: 1963 end-page: 300 ident: CR17 article-title: On the regulation of DNA synthesis in bacteria: the hypothesis of the replicon publication-title: C. R. Hebd Seances Acad. Sci. – volume: 44 start-page: 85 year: 2011 end-page: 96 ident: CR30 article-title: CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.08.028 – volume: 43 start-page: 442 year: 2011 end-page: 446 ident: CR48 article-title: Exome sequencing identifies GRIN2A as frequently mutated in melanoma publication-title: Nat. Genet. doi: 10.1038/ng.810 – volume: 23 start-page: 897 year: 2004 end-page: 907 ident: CR13 article-title: DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding publication-title: EMBO J. doi: 10.1038/sj.emboj.7600077 – volume: 60 start-page: 824 year: 2008 end-page: 833 ident: CR50 article-title: Joining the loops: beta-globin gene regulation publication-title: IUBMB Life doi: 10.1002/iub.129 – volume: 105 start-page: 15837 year: 2008 end-page: 15842 ident: CR51 article-title: Genome-wide studies highlight indirect links between human replication origins and gene regulation publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0805208105 – volume: 286 start-page: 22314 year: 2011 end-page: 22322 ident: CR58 article-title: RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.222802 – volume: 20 start-page: 6150 year: 2001 end-page: 6157 ident: CR40 article-title: Developmental regulation of DNA replication timing at the human beta globin locus publication-title: EMBO J. doi: 10.1093/emboj/20.21.6150 – volume: 36 start-page: 405 year: 2011 end-page: 414 ident: CR60 article-title: How dormant origins promote complete genome replication publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2011.05.002 – volume: 19 start-page: 621 year: 1977 end-page: 626 ident: CR45 article-title: Characterization of EBV-genome negative ‘null’ and ‘T’ cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma publication-title: Int. J. Cancer doi: 10.1002/ijc.2910190505 – volume: 23 start-page: 1 year: 2013 end-page: 11 ident: CR16 article-title: Genome-wide mapping of human DNA-replication origins: Levels of transcription at ORC1 sites regulate origin selection and replication timing publication-title: Genome Res. doi: 10.1101/gr.142331.112 – volume: 109 start-page: 7067 year: 2012 ident: BFncomms11748_CR27 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1119949109 – volume: 30 start-page: 1382 year: 2010 ident: BFncomms11748_CR21 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.01290-09 – volume: 4 start-page: e06496 year: 2015 ident: BFncomms11748_CR22 publication-title: eLife doi: 10.7554/eLife.06496 – volume: 584 start-page: 4121 year: 2010 ident: BFncomms11748_CR26 publication-title: FEBS Lett. doi: 10.1016/j.febslet.2010.08.042 – volume: 24 start-page: 748 year: 2010 ident: BFncomms11748_CR14 publication-title: Genes Dev. doi: 10.1101/gad.1913210 – volume: 96 start-page: 592 year: 1999 ident: BFncomms11748_CR32 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.96.2.592 – volume: 24 start-page: 572 year: 2006 ident: BFncomms11748_CR35 publication-title: Nat. Biotechnol. doi: 10.1038/nbt1202 – volume: 18 start-page: 63 year: 2010 ident: BFncomms11748_CR19 publication-title: Chromosome Res. doi: 10.1007/s10577-009-9087-1 – volume: 43 start-page: 442 year: 2011 ident: BFncomms11748_CR48 publication-title: Nat. Genet. doi: 10.1038/ng.810 – volume: 25 start-page: 1158 year: 2003 ident: BFncomms11748_CR11 publication-title: Bioessays doi: 10.1002/bies.10370 – volume: 281 start-page: 1005 year: 1998 ident: BFncomms11748_CR31 publication-title: Science doi: 10.1126/science.281.5379.1005 – volume: 85 start-page: 8081 year: 1988 ident: BFncomms11748_CR39 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.85.21.8081 – volume: 256 start-page: 298 year: 1963 ident: BFncomms11748_CR17 publication-title: C. R. Hebd Seances Acad. Sci. – volume: 20 start-page: 6150 year: 2001 ident: BFncomms11748_CR40 publication-title: EMBO J. doi: 10.1093/emboj/20.21.6150 – volume: 270 start-page: 815 year: 1995 ident: BFncomms11748_CR49 publication-title: Science doi: 10.1126/science.270.5237.815 – volume: 366 start-page: 588 year: 1993 ident: BFncomms11748_CR33 publication-title: Nature doi: 10.1038/366588a0 – volume: 6 start-page: 476 year: 2005 ident: BFncomms11748_CR9 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1663 – volume: 8 start-page: 588 year: 2007 ident: BFncomms11748_CR3 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2143 – volume: 286 start-page: 22314 year: 2011 ident: BFncomms11748_CR58 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.222802 – volume: 11 start-page: 728 year: 2010 ident: BFncomms11748_CR1 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2976 – volume: 44 start-page: 62 year: 2011 ident: BFncomms11748_CR23 publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.06.021 – volume: 23 start-page: 709 year: 2006 ident: BFncomms11748_CR28 publication-title: Mol. Cell doi: 10.1016/j.molcel.2006.08.010 – volume: 44 start-page: 72 year: 2011 ident: BFncomms11748_CR29 publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.06.036 – volume: 75 start-page: 143 year: 2010 ident: BFncomms11748_CR5 publication-title: Cold Spring Harb. Symp. Quant. Biol. doi: 10.1101/sqb.2010.75.011 – volume: 44 start-page: 85 year: 2011 ident: BFncomms11748_CR30 publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.08.028 – volume: 42 start-page: 4283 year: 2014 ident: BFncomms11748_CR54 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku072 – volume: 79 start-page: 89 year: 2010 ident: BFncomms11748_CR10 publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.052308.103205 – volume: 18 start-page: 137 year: 2010 ident: BFncomms11748_CR52 publication-title: Chromosome Res. doi: 10.1007/s10577-009-9105-3 – volume: 24 start-page: 3373 year: 2004 ident: BFncomms11748_CR34 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.24.8.3373-3386.2004 – volume: 31 start-page: 3472 year: 2011 ident: BFncomms11748_CR46 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.05587-11 – volume: 27 start-page: 5806 year: 2007 ident: BFncomms11748_CR53 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.02278-06 – volume: 22 start-page: 8426 year: 2002 ident: BFncomms11748_CR6 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.22.24.8426-8437.2002 – volume: 21 start-page: 1438 year: 2011 ident: BFncomms11748_CR7 publication-title: Genome Res. doi: 10.1101/gr.121830.111 – volume: 39 start-page: 3141 year: 2011 ident: BFncomms11748_CR15 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq1276 – volume: 23 start-page: 1 year: 2013 ident: BFncomms11748_CR16 publication-title: Genome Res. doi: 10.1101/gr.142331.112 – volume: 4 start-page: 1637 year: 1990 ident: BFncomms11748_CR38 publication-title: Genes Dev. doi: 10.1101/gad.4.10.1637 – volume: 11 start-page: e1004923 year: 2015 ident: BFncomms11748_CR57 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004923 – volume: 17 start-page: 416 year: 2000 ident: BFncomms11748_CR43 publication-title: Mol. Biol. Evol. doi: 10.1093/oxfordjournals.molbev.a026321 – volume: 9 start-page: e1003542 year: 2013 ident: BFncomms11748_CR55 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1003542 – volume: 86 start-page: 7470 year: 1989 ident: BFncomms11748_CR37 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.86.19.7470 – volume: 87 start-page: 279 year: 2002 ident: BFncomms11748_CR42 publication-title: J. Cell Biochem. doi: 10.1002/jcb.10298 – volume: 275 start-page: 40492 year: 2000 ident: BFncomms11748_CR24 publication-title: J. Biol. Chem. doi: 10.1074/jbc.C000611200 – volume: 30 start-page: 1495 year: 2010 ident: BFncomms11748_CR20 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.00710-09 – volume: 18 start-page: 231 year: 2006 ident: BFncomms11748_CR8 publication-title: Curr. Opin. Cell. Biol. doi: 10.1016/j.ceb.2006.04.001 – volume: 23 start-page: 897 year: 2004 ident: BFncomms11748_CR13 publication-title: EMBO J. doi: 10.1038/sj.emboj.7600077 – volume: 21 start-page: 5 year: 1999 ident: BFncomms11748_CR56 publication-title: Bioessays doi: 10.1002/(SICI)1521-1878(199901)21:1<5::AID-BIES2>3.0.CO;2-6 – volume: 27 start-page: 6484 year: 2007 ident: BFncomms11748_CR25 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.02409-06 – volume: 21 start-page: 1822 year: 2011 ident: BFncomms11748_CR4 publication-title: Genome Res. doi: 10.1101/gr.124644.111 – volume: 10 start-page: 277 year: 2009 ident: BFncomms11748_CR47 publication-title: BMC Genomics doi: 10.1186/1471-2164-10-277 – volume: 105 start-page: 15837 year: 2008 ident: BFncomms11748_CR51 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0805208105 – volume: 8 start-page: 4958 year: 1988 ident: BFncomms11748_CR36 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.8.11.4958 – volume: 24 start-page: 236 year: 2000 ident: BFncomms11748_CR64 publication-title: Nat. Genet. doi: 10.1038/73439 – volume: 19 start-page: 621 year: 1977 ident: BFncomms11748_CR45 publication-title: Int. J. Cancer doi: 10.1002/ijc.2910190505 – volume: 19 start-page: 837 year: 2012 ident: BFncomms11748_CR18 publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.2339 – volume: 6 start-page: 6746 year: 2015 ident: BFncomms11748_CR62 publication-title: Nat. Commun. doi: 10.1038/ncomms7746 – volume: 60 start-page: 824 year: 2008 ident: BFncomms11748_CR50 publication-title: IUBMB Life doi: 10.1002/iub.129 – volume: 28 start-page: 5621 year: 2008 ident: BFncomms11748_CR59 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.00232-08 – volume: 29 start-page: 3260 year: 2010 ident: BFncomms11748_CR44 publication-title: EMBO J. doi: 10.1038/emboj.2010.204 – volume: 375 start-page: 1152 year: 2008 ident: BFncomms11748_CR63 publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2007.11.006 – volume: 28 start-page: 22 year: 2012 ident: BFncomms11748_CR61 publication-title: Trends Genet. doi: 10.1016/j.tig.2011.10.003 – volume: 29 start-page: 809 year: 2001 ident: BFncomms11748_CR41 publication-title: Nucleic Acids Res. doi: 10.1093/nar/29.3.809 – volume: 2 start-page: 307 year: 2003 ident: BFncomms11748_CR2 publication-title: Cell Cycle doi: 10.4161/cc.2.4.435 – volume: 17 start-page: 1894 year: 2003 ident: BFncomms11748_CR12 publication-title: Genes Dev. doi: 10.1101/gad.1084203 – volume: 36 start-page: 405 year: 2011 ident: BFncomms11748_CR60 publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2011.05.002 – volume: 112 start-page: 1997 year: 2011 ident: BFncomms11748_CR65 publication-title: J. Cell. Biochem. doi: 10.1002/jcb.23117 – reference: 21981919 - Mol Cell. 2011 Oct 7;44(1):72-84 – reference: 21856198 - Mol Cell. 2011 Oct 7;44(1):62-71 – reference: 10723742 - Mol Biol Evol. 2000 Mar;17(3):416-22 – reference: 21641805 - Trends Biochem Sci. 2011 Aug;36(8):405-14 – reference: 13964280 - C R Hebd Seances Acad Sci. 1963 Jan 2;256:298-300 – reference: 19904620 - Chromosome Res. 2010 Jan;18(1):63-77 – reference: 21445863 - J Cell Biochem. 2011 Aug;112(8):1997-2005 – reference: 22094264 - Trends Genet. 2012 Jan;28(1):22-32 – reference: 20816727 - FEBS Lett. 2010 Sep 24;584(18):4121-7 – reference: 16604060 - Nat Biotechnol. 2006 May;24(5):572-6 – reference: 20066560 - Chromosome Res. 2010 Jan;18(1):137-45 – reference: 21750104 - Genome Res. 2011 Sep;21(9):1438-49 – reference: 23187890 - Genome Res. 2013 Jan;23(1):1-11 – reference: 14765124 - EMBO J. 2004 Feb 25;23(4):897-907 – reference: 18767169 - IUBMB Life. 2008 Dec;60(12):824-33 – reference: 22511720 - Proc Natl Acad Sci U S A. 2012 May 1;109(18):7067-72 – reference: 21690294 - Mol Cell Biol. 2011 Aug;31(16):3472-84 – reference: 21148149 - Nucleic Acids Res. 2011 Apr;39(8):3141-55 – reference: 7481774 - Science. 1995 Nov 3;270(5237):815-9 – reference: 20065034 - Mol Cell Biol. 2010 Mar;30(6):1495-507 – reference: 2249769 - Genes Dev. 1990 Oct;4(10):1637-49 – reference: 9892678 - Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):592-7 – reference: 22751019 - Nat Struct Mol Biol. 2012 Aug;19(8):837-44 – reference: 68013 - Int J Cancer. 1977 May 15;19(5):621-6 – reference: 20351051 - Genes Dev. 2010 Apr 15;24(8):748-53 – reference: 19549304 - BMC Genomics. 2009 Jun 23;10:277 – reference: 2798417 - Proc Natl Acad Sci U S A. 1989 Oct;86(19):7470-4 – reference: 15060158 - Mol Cell Biol. 2004 Apr;24(8):3373-86 – reference: 2850471 - Mol Cell Biol. 1988 Nov;8(11):4958-65 – reference: 17636024 - Mol Cell Biol. 2007 Sep;27(18):6484-96 – reference: 17515603 - Mol Cell Biol. 2007 Aug;27(16):5806-18 – reference: 18838675 - Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15837-42 – reference: 25569254 - PLoS Genet. 2015 Jan 08;11(1):e1004923 – reference: 25922909 - Elife. 2015 Apr 29;4:null – reference: 24470145 - Nucleic Acids Res. 2014 Apr;42(7):4283-93 – reference: 11018022 - J Biol Chem. 2000 Dec 22;275(51):40492-7 – reference: 12397609 - J Cell Biochem. 2002;87(3):279-83 – reference: 12897055 - Genes Dev. 2003 Aug 1;17(15):1894-908 – reference: 21139067 - Cold Spring Harb Symp Quant Biol. 2010;75:143-53 – reference: 20861881 - Nat Rev Mol Cell Biol. 2010 Oct;11(10):728-38 – reference: 15928711 - Nat Rev Mol Cell Biol. 2005 Jun;6(6):476-86 – reference: 16949367 - Mol Cell. 2006 Sep 1;23 (5):709-21 – reference: 18054789 - J Mol Biol. 2008 Jan 25;375(4):1152-64 – reference: 20065033 - Mol Cell Biol. 2010 Mar;30(6):1382-96 – reference: 20373915 - Annu Rev Biochem. 2010;79:89-130 – reference: 3186709 - Proc Natl Acad Sci U S A. 1988 Nov;85(21):8081-5 – reference: 16650748 - Curr Opin Cell Biol. 2006 Jun;18(3):231-9 – reference: 23754963 - PLoS Genet. 2013 Jun;9(6):e1003542 – reference: 11689454 - EMBO J. 2001 Nov 1;20(21):6150-7 – reference: 20808282 - EMBO J. 2010 Oct 6;29(19):3260-71 – reference: 9703500 - Science. 1998 Aug 14;281(5379):1005-9 – reference: 12851480 - Cell Cycle. 2003 Jul-Aug;2(4):307-9 – reference: 21813623 - Genome Res. 2011 Nov;21(11):1822-32 – reference: 18606781 - Mol Cell Biol. 2008 Sep;28(18):5621-33 – reference: 14635251 - Bioessays. 2003 Dec;25(12):1158-67 – reference: 21558276 - J Biol Chem. 2011 Jun 24;286(25):22314-22 – reference: 10070250 - Bioessays. 1999 Jan;21(1):5-16 – reference: 10700175 - Nat Genet. 2000 Mar;24(3):236-44 – reference: 8255298 - Nature. 1993 Dec 9;366(6455):588-90 – reference: 11160905 - Nucleic Acids Res. 2001 Feb 1;29(3):809-17 – reference: 21981920 - Mol Cell. 2011 Oct 7;44(1):85-96 – reference: 25879486 - Nat Commun. 2015 Apr 16;6:6746 – reference: 17621316 - Nat Rev Genet. 2007 Aug;8(8):588-600 – reference: 12446763 - Mol Cell Biol. 2002 Dec;22(24):8426-37 – reference: 21499247 - Nat Genet. 2011 May;43(5):442-6 |
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| Snippet | Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential... Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein... |
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| SubjectTerms | 13/31 13/95 14/19 631/337/151 631/45/612/1229 Animals Base Sequence Binding sites Cell cycle Cell growth Cell Line Deoxyribonucleic acid DNA DNA Replication DNA-Binding Proteins - metabolism Embryo, Mammalian - cytology Fibroblasts - metabolism Genetic Loci Genome Genomes Humanities and Social Sciences Humans Locus Control Region Mammals Mammals - metabolism Mice Models, Biological multidisciplinary Protein Binding Proteins Replication Origin Science Science (multidisciplinary) Site selection Yeast |
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| Title | A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells |
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