An experimental phylogeny to benchmark ancestral sequence reconstruction

Ancestral sequence reconstruction (ASR) is a still-burgeoning method that has revealed many key mechanisms of molecular evolution. One criticism of the approach is an inability to validate its algorithms within a biological context as opposed to a computer simulation. Here we build an experimental p...

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Bibliographic Details
Published in:	Nature communications Vol. 7; no. 1; pp. 12847 - 6
Main Authors:	Randall, Ryan N., Radford, Caelan E., Roof, Kelsey A., Natarajan, Divya K., Gaucher, Eric A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.09.2016 Nature Publishing Group Nature Portfolio
Subjects:	631/181/2475 631/181/757 82 82/83 Accuracy Algorithms Amino acids Base Sequence Bayes Theorem Bioengineering Computer Simulation Genetic Techniques Genotypes Humanities and Social Sciences Leaves Luminescent Proteins - genetics multidisciplinary Mutagenesis Phenotype Phylogeny Proteins Red Fluorescent Protein Science Science (multidisciplinary) Taxonomy Atlanta Georgia United States > US Georgia
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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