Specialized interfaces of Smc5/6 control hinge stability and DNA association

The Structural Maintenance of Chromosomes (SMC) complexes: cohesin, condensin and Smc5/6 are involved in the organization of higher-order chromosome structure—which is essential for accurate chromosome duplication and segregation. Each complex is scaffolded by a specific SMC protein dimer (heterodim...

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Bibliographic Details
Published in:	Nature communications Vol. 8; no. 1; p. 14011
Main Authors:	Alt, Aaron, Dang, Hung Q., Wells, Owen S., Polo, Luis M., Smith, Matt A., McGregor, Grant A., Welte, Thomas, Lehmann, Alan R., Pearl, Laurence H., Murray, Johanne M., Oliver, Antony W.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.01.2017 Nature Publishing Group Nature Portfolio
Subjects:	631/337/103 631/337/641/2002 631/45/535 631/45/612/1229 Adenosine Triphosphatases - chemistry Binding Sites Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Survival - physiology Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosomes Cohesins Crystallography, X-Ray Deoxyribonucleic acid DNA DNA Damage DNA Repair - physiology DNA, Single-Stranded - metabolism DNA-Binding Proteins - chemistry Genomes Humanities and Social Sciences Humans Life sciences Models, Molecular multidisciplinary Multiprotein Complexes - chemistry Mutagenesis, Site-Directed Mutation Phenotype Protein Binding Protein Domains - physiology Protein Multimerization - physiology Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Schizosaccharomyces - physiology Schizosaccharomyces pombe Proteins - chemistry Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Science Science (multidisciplinary) Yeast Yeasts United Kingdom > UK
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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