Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia

Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq...

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Vydáno v:	Nature communications Ročník 9; číslo 1; s. 3121 - 15
Hlavní autoři:	Bryois, Julien, Garrett, Melanie E., Song, Lingyun, Safi, Alexias, Giusti-Rodriguez, Paola, Johnson, Graham D., Shieh, Annie W., Buil, Alfonso, Fullard, John F., Roussos, Panos, Sklar, Pamela, Akbarian, Schahram, Haroutunian, Vahram, Stockmeier, Craig A., Wray, Gregory A., White, Kevin P., Liu, Chunyu, Reddy, Timothy E., Ashley-Koch, Allison, Sullivan, Patrick F., Crawford, Gregory E.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 07.08.2018 Nature Publishing Group Nature Portfolio
Témata:	13 38 45 631/337/100/102 631/378/1689/1799 Accessibility Age Aged Aged, 80 and over Brain Brain - physiopathology Chromatin Chromatin - chemistry Conserved sequence Female Gene Expression Profiling Gene mapping Genome-wide association studies Genome-Wide Association Study Genomes Health risks Heritability High-Throughput Nucleotide Sequencing Humanities and Social Sciences Humans Male Mental disorders Middle Aged multidisciplinary Mutation Non-coding RNA Polymorphism, Single Nucleotide Prefrontal cortex Prefrontal Cortex - metabolism Quantitative Trait Loci Regulatory sequences Risk Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Science Science (multidisciplinary) Sequence Analysis, DNA
ISSN:	2041-1723, 2041-1723
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Abstract	Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq on adult prefrontal cortex brain samples from 135 individuals with schizophrenia and 137 controls, and identified 118,152 ATAC-seq peaks. These accessible chromatin regions in the brain are highly enriched for schizophrenia SNP heritability. Accessible chromatin regions that overlap evolutionarily conserved regions exhibit an even higher heritability enrichment, indicating that sequence conservation can further refine functional risk variants. We identify few differences in chromatin accessibility between cases and controls, in contrast to thousands of age-related differential accessible chromatin regions. Altogether, we characterize chromatin accessibility in the human prefrontal cortex, the effect of schizophrenia and age on chromatin accessibility, and provide evidence that our dataset will allow for fine mapping of risk variants. Chromatin accessibility may be altered in disease states. Here the authors carry out ATAC-seq on a large number of samples of dorsolateral prefrontal cortex from individuals with schizophrenia, and healthy controls.
AbstractList	Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq on adult prefrontal cortex brain samples from 135 individuals with schizophrenia and 137 controls, and identified 118,152 ATAC-seq peaks. These accessible chromatin regions in the brain are highly enriched for schizophrenia SNP heritability. Accessible chromatin regions that overlap evolutionarily conserved regions exhibit an even higher heritability enrichment, indicating that sequence conservation can further refine functional risk variants. We identify few differences in chromatin accessibility between cases and controls, in contrast to thousands of age-related differential accessible chromatin regions. Altogether, we characterize chromatin accessibility in the human prefrontal cortex, the effect of schizophrenia and age on chromatin accessibility, and provide evidence that our dataset will allow for fine mapping of risk variants. Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq on adult prefrontal cortex brain samples from 135 individuals with schizophrenia and 137 controls, and identified 118,152 ATAC-seq peaks. These accessible chromatin regions in the brain are highly enriched for schizophrenia SNP heritability. Accessible chromatin regions that overlap evolutionarily conserved regions exhibit an even higher heritability enrichment, indicating that sequence conservation can further refine functional risk variants. We identify few differences in chromatin accessibility between cases and controls, in contrast to thousands of age-related differential accessible chromatin regions. Altogether, we characterize chromatin accessibility in the human prefrontal cortex, the effect of schizophrenia and age on chromatin accessibility, and provide evidence that our dataset will allow for fine mapping of risk variants. Chromatin accessibility may be altered in disease states. Here the authors carry out ATAC-seq on a large number of samples of dorsolateral prefrontal cortex from individuals with schizophrenia, and healthy controls. Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq on adult prefrontal cortex brain samples from 135 individuals with schizophrenia and 137 controls, and identified 118,152 ATAC-seq peaks. These accessible chromatin regions in the brain are highly enriched for schizophrenia SNP heritability. Accessible chromatin regions that overlap evolutionarily conserved regions exhibit an even higher heritability enrichment, indicating that sequence conservation can further refine functional risk variants. We identify few differences in chromatin accessibility between cases and controls, in contrast to thousands of age-related differential accessible chromatin regions. Altogether, we characterize chromatin accessibility in the human prefrontal cortex, the effect of schizophrenia and age on chromatin accessibility, and provide evidence that our dataset will allow for fine mapping of risk variants. Chromatin accessibility may be altered in disease states. Here the authors carry out ATAC-seq on a large number of samples of dorsolateral prefrontal cortex from individuals with schizophrenia, and healthy controls. Chromatin accessibility may be altered in disease states. Here the authors carry out ATAC-seq on a large number of samples of dorsolateral prefrontal cortex from individuals with schizophrenia, and healthy controls. Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq on adult prefrontal cortex brain samples from 135 individuals with schizophrenia and 137 controls, and identified 118,152 ATAC-seq peaks. These accessible chromatin regions in the brain are highly enriched for schizophrenia SNP heritability. Accessible chromatin regions that overlap evolutionarily conserved regions exhibit an even higher heritability enrichment, indicating that sequence conservation can further refine functional risk variants. We identify few differences in chromatin accessibility between cases and controls, in contrast to thousands of age-related differential accessible chromatin regions. Altogether, we characterize chromatin accessibility in the human prefrontal cortex, the effect of schizophrenia and age on chromatin accessibility, and provide evidence that our dataset will allow for fine mapping of risk variants.Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq on adult prefrontal cortex brain samples from 135 individuals with schizophrenia and 137 controls, and identified 118,152 ATAC-seq peaks. These accessible chromatin regions in the brain are highly enriched for schizophrenia SNP heritability. Accessible chromatin regions that overlap evolutionarily conserved regions exhibit an even higher heritability enrichment, indicating that sequence conservation can further refine functional risk variants. We identify few differences in chromatin accessibility between cases and controls, in contrast to thousands of age-related differential accessible chromatin regions. Altogether, we characterize chromatin accessibility in the human prefrontal cortex, the effect of schizophrenia and age on chromatin accessibility, and provide evidence that our dataset will allow for fine mapping of risk variants.
ArticleNumber	3121
Author	Fullard, John F. Ashley-Koch, Allison Safi, Alexias Giusti-Rodriguez, Paola Garrett, Melanie E. White, Kevin P. Shieh, Annie W. Reddy, Timothy E. Roussos, Panos Johnson, Graham D. Liu, Chunyu Sullivan, Patrick F. Song, Lingyun Akbarian, Schahram Crawford, Gregory E. Buil, Alfonso Stockmeier, Craig A. Sklar, Pamela Bryois, Julien Haroutunian, Vahram Wray, Gregory A.
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Cites_doi	10.1371/journal.pgen.1004383 10.1186/s13059-014-0550-8 10.1038/s41588-018-0059-2 10.1016/j.molcel.2010.05.004 10.1371/journal.pgen.0020190 10.1523/JNEUROSCI.2319-13.2014 10.1001/jamapsychiatry.2013.3730 10.1016/B978-0-12-801311-3.00005-6 10.1146/annurev.bi.57.070188.001111 10.1016/j.celrep.2016.10.061 10.1242/dev.085621 10.1016/j.cell.2016.07.049 10.1073/pnas.1530509100 10.1038/ng.3404 10.1093/cercor/bhs307 10.1038/nbt.3853 10.1016/j.celrep.2014.10.015 10.1038/nn.2702 10.1038/nn.4156 10.1038/nn.3995 10.1111/j.1460-9568.2009.06768.x 10.1038/nature09230 10.1038/nature14590 10.1038/nn.4267 10.1073/pnas.0701946104 10.1038/nature10808 10.1001/archpsyc.60.12.1187 10.1176/appi.ajp.2017.17030283 10.1038/nbt.2931 10.1038/nmeth.1923 10.1038/nn.4181 10.1038/ncomms12230 10.1186/gb-2007-8-5-r72 10.1016/j.mcn.2004.01.004 10.1371/journal.pcbi.1004219 10.1074/jbc.M600521200 10.1038/nbt.1630 10.1186/gb-2012-13-8-418 10.1016/j.cell.2015.04.004 10.1001/archgenpsychiatry.2009.10 10.1523/JNEUROSCI.1641-17.2017 10.1093/bioinformatics/btp352 10.1093/hmg/ddn288 10.1093/hmg/ddx103 10.1016/j.cell.2014.11.021 10.1093/biostatistics/kxr034 10.1038/nature10530 10.1038/nature12929 10.1038/nmeth.2688 10.1038/nn.4399 10.1186/s13742-015-0047-8 10.1016/S0896-6273(03)00163-6 10.1038/nature14248 10.1038/s41588-018-0129-5 10.1038/mp.2011.11 10.1017/S0033291706008385 10.1093/bioinformatics/btv722 10.1371/journal.pbio.1001046 10.1101/gr.121541.111 10.1016/j.ydbio.2014.11.012 10.1002/0471250953.bi1112s47 10.1038/nature19847 10.1038/nature16549 10.1016/j.celrep.2015.02.025 10.3791/914 10.3390/cells6030026 10.7554/eLife.12717 10.1038/nature13595 10.1038/ng0417-651d 10.14806/ej.17.1.200
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References	Vockley (CR49) 2016; 166 Buenrostro (CR53) 2015; 523 Ramos, Gaudilliere, Bonni, Gill (CR39) 2007; 104 (CR14) 2011; 9 Li (CR59) 2009; 25 Heng (CR32) 2014; 24 Ma, Zheng, Zuo (CR28) 2006; 281 Won (CR12) 2016; 538 Gross, Garrard (CR21) 1988; 57 Langmead, Salzberg (CR58) 2012; 9 Storey, Tibshirani (CR63) 2003; 100 Sullivan (CR1) 2018; 175 de Leeuw, Mooij, Heskes, Posthuma (CR40) 2015; 11 Piper (CR37) 2014; 34 Pardinas (CR6) 2018; 50 Jaffe (CR20) 2016; 19 Mouse Encode (CR52) 2012; 13 Chang (CR56) 2015; 4 Fromer (CR11) 2016; 19 CR5 Huang (CR44) 2011; 14 CR8 Barbalat, Chambon, Franck, Koechlin, Farrer (CR54) 2009; 66 Degner (CR45) 2012; 482 Frank (CR47) 2015; 18 Liang (CR31) 2013; 140 CR43 Skene (CR46) 2018; 50 Roussos (CR13) 2014; 9 CR41 Stergiopoulos, Politis (CR42) 2016; 7 de Bakker (CR67) 2008; 17 Love, Huber, Anders (CR66) 2014; 15 Singh (CR7) 2016; 19 Buenrostro, Giresi, Zaba, Chang, Greenleaf (CR23) 2013; 10 McClard (CR38) 2018; 38 Åberg (CR19) 2014; 71 Fullard (CR22) 2017; 26 Psych (CR16) 2015; 18 Lupianez (CR48) 2015; 161 Patterson, Price, Reich (CR61) 2006; 22 Lindblad-Toh (CR26) 2011; 478 Klann (CR50) 2017; 35 CR57 (CR15) 2015; 518 Finucane (CR25) 2015; 47 CR51 Aruga (CR34) 2004; 26 Song (CR24) 2011; 21 Heinz (CR71) 2010; 38 Haslinger, Schwarz, Covic, Lie (CR33) 2009; 29 Rao (CR27) 2014; 159 McLean (CR70) 2010; 28 Giambartolomei (CR64) 2014; 10 Schmitt (CR65) 2016; 17 Whittington, Cunningham, Le, De Maria, Silva (CR30) 2015; 397 Risso, Ngai, Speed, Dudoit (CR68) 2014; 32 Gavin, Floreani (CR18) 2014; 115 Sullivan, Kendler, Neale (CR3) 2003; 60 CR29 Quinlan (CR60) 2014; 47 Petronis (CR17) 2010; 465 Van der Auwera (CR55) 2013; 11 Fromer (CR4) 2014; 506 Sekar (CR9) 2016; 530 Wong (CR36) 2007; 8 Ongen, Buil, Brown, Dermitzakis, Delaneau (CR62) 2016; 32 Gagnon-Bartsch, Speed (CR69) 2012; 13 Richards (CR10) 2012; 17 Lichtenstein (CR2) 2006; 36 Kim, Lo, Dormand, Anderson (CR35) 2003; 38 A Petronis (5379_CR17) 2010; 465 JA Gagnon-Bartsch (5379_CR69) 2012; 13 AL Richards (5379_CR10) 2012; 17 DS Gross (5379_CR21) 1988; 57 JK Huang (5379_CR44) 2011; 14 M Fromer (5379_CR11) 2016; 19 CM Vockley (5379_CR49) 2016; 166 YH Heng (5379_CR32) 2014; 24 B Ramos (5379_CR39) 2007; 104 NG Skene (5379_CR46) 2018; 50 5379_CR43 SS Rao (5379_CR27) 2014; 159 M Fromer (5379_CR4) 2014; 506 T Singh (5379_CR7) 2016; 19 5379_CR41 D Risso (5379_CR68) 2014; 32 YW Wong (5379_CR36) 2007; 8 CL Frank (5379_CR47) 2015; 18 MI Love (5379_CR66) 2014; 15 K Lindblad-Toh (5379_CR26) 2011; 478 C Giambartolomei (5379_CR64) 2014; 10 H Li (5379_CR59) 2009; 25 AF Pardinas (5379_CR6) 2018; 50 K Ma (5379_CR28) 2006; 281 EC Psych (5379_CR16) 2015; 18 5379_CR57 CK McClard (5379_CR38) 2018; 38 H Won (5379_CR12) 2016; 538 HK Finucane (5379_CR25) 2015; 47 G Barbalat (5379_CR54) 2009; 66 AD Schmitt (5379_CR65) 2016; 17 J Kim (5379_CR35) 2003; 38 5379_CR51 PF Sullivan (5379_CR1) 2018; 175 CY McLean (5379_CR70) 2010; 28 DP Gavin (5379_CR18) 2014; 115 Encode Project Consortium. (5379_CR14) 2011; 9 JD Storey (5379_CR63) 2003; 100 B Langmead (5379_CR58) 2012; 9 5379_CR5 S Heinz (5379_CR71) 2010; 38 L Song (5379_CR24) 2011; 21 5379_CR29 TS Klann (5379_CR50) 2017; 35 KA Åberg (5379_CR19) 2014; 71 5379_CR8 JF Fullard (5379_CR22) 2017; 26 AR Quinlan (5379_CR60) 2014; 47 P Lichtenstein (5379_CR2) 2006; 36 Roadmap Epigenomics Consortium (5379_CR15) 2015; 518 CA de Leeuw (5379_CR40) 2015; 11 AE Jaffe (5379_CR20) 2016; 19 M Piper (5379_CR37) 2014; 34 A Stergiopoulos (5379_CR42) 2016; 7 GA Van der Auwera (5379_CR55) 2013; 11 JD Buenrostro (5379_CR23) 2013; 10 N Patterson (5379_CR61) 2006; 22 Consortium Mouse Encode (5379_CR52) 2012; 13 PF Sullivan (5379_CR3) 2003; 60 H Liang (5379_CR31) 2013; 140 JD Buenrostro (5379_CR53) 2015; 523 N Whittington (5379_CR30) 2015; 397 A Sekar (5379_CR9) 2016; 530 J Aruga (5379_CR34) 2004; 26 PI de Bakker (5379_CR67) 2008; 17 P Roussos (5379_CR13) 2014; 9 JF Degner (5379_CR45) 2012; 482 A Haslinger (5379_CR33) 2009; 29 CC Chang (5379_CR56) 2015; 4 DG Lupianez (5379_CR48) 2015; 161 H Ongen (5379_CR62) 2016; 32
References_xml	– volume: 10 start-page: e1004383 year: 2014 ident: CR64 article-title: Bayesian test for colocalisation between pairs of genetic association studies using summary statistics publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004383 – volume: 15 year: 2014 ident: CR66 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – ident: CR51 – volume: 50 start-page: 381 year: 2018 end-page: 389 ident: CR6 article-title: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection publication-title: Nat. Genet. doi: 10.1038/s41588-018-0059-2 – volume: 38 start-page: 576 year: 2010 end-page: 589 ident: CR71 article-title: Simple combinations of lineage-determining transcription factors prime -regulatory elements required for macrophage and B cell identities publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.05.004 – volume: 22 start-page: e190 year: 2006 ident: CR61 article-title: Population structure and eigenanalysis publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0020190 – ident: CR29 – volume: 34 start-page: 2921 year: 2014 end-page: 2930 ident: CR37 article-title: NFIB-mediated repression of the epigenetic factor Ezh2 regulates cortical development publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2319-13.2014 – volume: 71 start-page: 255 year: 2014 end-page: 264 ident: CR19 article-title: Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2013.3730 – ident: CR8 – volume: 115 start-page: 155 year: 2014 end-page: 201 ident: CR18 article-title: Epigenetics of schizophrenia: an open and shut case publication-title: Int. Rev. Neurobiol. doi: 10.1016/B978-0-12-801311-3.00005-6 – volume: 57 start-page: 159 year: 1988 end-page: 197 ident: CR21 article-title: Nuclease hypersensitive sites in chromatin publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.bi.57.070188.001111 – volume: 17 start-page: 2042 year: 2016 end-page: 2059 ident: CR65 article-title: A compendium of chromatin contact maps reveals spatially active regions in the human genome publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.10.061 – volume: 140 start-page: 552 year: 2013 end-page: 561 ident: CR31 article-title: Neural development is dependent on the function of specificity protein 2 in cell cycle progression publication-title: Development doi: 10.1242/dev.085621 – volume: 166 start-page: 1269 year: 2016 end-page: 1281 e1219 ident: CR49 article-title: Direct GR binding sites potentiate clusters of TF binding across the human genome publication-title: Cell doi: 10.1016/j.cell.2016.07.049 – volume: 100 start-page: 9440 year: 2003 end-page: 9445 ident: CR63 article-title: Statistical significance for genomewide studies publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1530509100 – volume: 47 start-page: 1228 year: 2015 end-page: 1235 ident: CR25 article-title: Partitioning heritability by functional category using GWAS summary statistics publication-title: Nat. Genet. doi: 10.1038/ng.3404 – volume: 24 start-page: 261 year: 2014 end-page: 279 ident: CR32 article-title: NFIX regulates neural progenitor cell differentiation during hippocampal morphogenesis publication-title: Cereb. Cortex doi: 10.1093/cercor/bhs307 – volume: 35 start-page: 561 year: 2017 end-page: 568 ident: CR50 article-title: CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3853 – volume: 11 start-page: 11 10 11 year: 2013 end-page: 11 10 33 ident: CR55 article-title: From FastQ data to high confidence variant calls: the Genome Analysis Toolkit best practices pipeline publication-title: Curr. Protoc. Bioinform. – volume: 9 start-page: 1417 year: 2014 end-page: 1429 ident: CR13 article-title: A role for noncoding variation in schizophrenia publication-title: Cell Rep. doi: 10.1016/j.celrep.2014.10.015 – volume: 14 start-page: 45 year: 2011 end-page: 53 ident: CR44 article-title: Retinoid X receptor gamma signaling accelerates CNS remyelination publication-title: Nat. Neurosci. doi: 10.1038/nn.2702 – volume: 18 start-page: 1707 year: 2015 end-page: 1712 ident: CR16 article-title: The PsychENCODE project publication-title: Nat. Neurosci. doi: 10.1038/nn.4156 – volume: 18 start-page: 647 year: 2015 end-page: 656 ident: CR47 article-title: Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum publication-title: Nat. Neurosci. doi: 10.1038/nn.3995 – volume: 29 start-page: 2103 year: 2009 end-page: 2114 ident: CR33 article-title: Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2009.06768.x – ident: CR57 – volume: 465 start-page: 721 year: 2010 end-page: 727 ident: CR17 article-title: Epigenetics as a unifying principle in the aetiology of complex traits and diseases publication-title: Nature doi: 10.1038/nature09230 – volume: 523 start-page: 486 year: 2015 end-page: 490 ident: CR53 article-title: Single-cell chromatin accessibility reveals principles of regulatory variation publication-title: Nature doi: 10.1038/nature14590 – ident: CR5 – volume: 19 start-page: 571 year: 2016 end-page: 577 ident: CR7 article-title: Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders publication-title: Nat. Neurosci. doi: 10.1038/nn.4267 – volume: 104 start-page: 9882 year: 2007 end-page: 9887 ident: CR39 article-title: Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0701946104 – volume: 482 start-page: 390 year: 2012 end-page: 394 ident: CR45 article-title: DNase I sensitivity QTLs are a major determinant of human expression variation publication-title: Nature doi: 10.1038/nature10808 – volume: 60 start-page: 1187 year: 2003 end-page: 1192 ident: CR3 article-title: Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.60.12.1187 – volume: 175 start-page: 15 year: 2018 end-page: 27 ident: CR1 article-title: Psychiatric genomics: an update and an agenda publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2017.17030283 – volume: 32 start-page: 896 year: 2014 end-page: 902 ident: CR68 article-title: Normalization of RNA-seq data using factor analysis of control genes or samples publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2931 – volume: 9 start-page: 357 year: 2012 end-page: 359 ident: CR58 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 – volume: 19 start-page: 40 year: 2016 end-page: 47 ident: CR20 article-title: Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex publication-title: Nat. Neurosci. doi: 10.1038/nn.4181 – volume: 7 year: 2016 ident: CR42 article-title: Nuclear receptor NR5A2 controls neural stem cell fate decisions during development publication-title: Nat. Commun. doi: 10.1038/ncomms12230 – volume: 8 year: 2007 ident: CR36 article-title: Gene expression analysis of nuclear factor I–A deficient mice indicates delayed brain maturation publication-title: Genome Biol. doi: 10.1186/gb-2007-8-5-r72 – volume: 26 start-page: 205 year: 2004 end-page: 221 ident: CR34 article-title: The role of Zic genes in neural development publication-title: Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2004.01.004 – volume: 11 start-page: e1004219 year: 2015 ident: CR40 article-title: MAGMA: generalized gene-set analysis of GWAS data publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1004219 – ident: CR43 – volume: 281 start-page: 21250 year: 2006 end-page: 21255 ident: CR28 article-title: The transcription factor regulatory factor X1 increases the expression of neuronal glutamate transporter type 3 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M600521200 – volume: 28 start-page: 495 year: 2010 end-page: 501 ident: CR70 article-title: GREAT improves functional interpretation of -regulatory regions publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1630 – volume: 13 year: 2012 ident: CR52 article-title: An encyclopedia of mouse DNA elements (Mouse ENCODE) publication-title: Genome Biol. doi: 10.1186/gb-2012-13-8-418 – volume: 161 start-page: 1012 year: 2015 end-page: 1025 ident: CR48 article-title: Disruptions of topological chromatin domains cause pathogenic rewiring of gene–enhancer interactions publication-title: Cell doi: 10.1016/j.cell.2015.04.004 – volume: 66 start-page: 377 year: 2009 end-page: 386 ident: CR54 article-title: Organization of cognitive control within the lateral prefrontal cortex in schizophrenia publication-title: Arch. Gen. Psychiatry doi: 10.1001/archgenpsychiatry.2009.10 – volume: 38 start-page: 1443 year: 2018 end-page: 1461 ident: CR38 article-title: POU6f1 mediates neuropeptide-dependent plasticity in the adult brain publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1641-17.2017 – volume: 25 start-page: 2078 year: 2009 end-page: 2079 ident: CR59 article-title: The Sequence Alignment/Map format and SAMtools publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 17 start-page: R122 year: 2008 end-page: R128 ident: CR67 article-title: Practical aspects of imputation-driven meta-analysis of genome-wide association studies publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddn288 – volume: 26 start-page: 1942 year: 2017 end-page: 1951 ident: CR22 article-title: Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddx103 – volume: 159 start-page: 1665 year: 2014 end-page: 1680 ident: CR27 article-title: A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping publication-title: Cell doi: 10.1016/j.cell.2014.11.021 – volume: 13 start-page: 539 year: 2012 end-page: 552 ident: CR69 article-title: Using control genes to correct for unwanted variation in microarray data publication-title: Biostatistics doi: 10.1093/biostatistics/kxr034 – volume: 478 start-page: 476 year: 2011 end-page: 482 ident: CR26 article-title: A high-resolution map of human evolutionary constraint using 29 mammals publication-title: Nature doi: 10.1038/nature10530 – volume: 506 start-page: 179 year: 2014 end-page: 184 ident: CR4 article-title: De novo mutations in schizophrenia implicate synaptic networks publication-title: Nature doi: 10.1038/nature12929 – volume: 10 start-page: 1213 year: 2013 end-page: 1218 ident: CR23 article-title: Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position publication-title: Nat. Methods doi: 10.1038/nmeth.2688 – volume: 19 start-page: 1442 year: 2016 end-page: 1453 ident: CR11 article-title: Gene expression elucidates functional impact of polygenic risk for schizophrenia publication-title: Nat. Neurosci. doi: 10.1038/nn.4399 – volume: 4 year: 2015 ident: CR56 article-title: Second-generation PLINK: rising to the challenge of larger and richer datasets publication-title: Gigascience doi: 10.1186/s13742-015-0047-8 – volume: 38 start-page: 17 year: 2003 end-page: 31 ident: CR35 article-title: SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells publication-title: Neuron doi: 10.1016/S0896-6273(03)00163-6 – volume: 518 start-page: 317 year: 2015 end-page: 330 ident: CR15 article-title: Integrative analysis of 111 reference human epigenomes publication-title: Nature doi: 10.1038/nature14248 – volume: 50 start-page: 825 year: 2018 end-page: 833 ident: CR46 article-title: Genetic identification of brain cell types underlying schizophrenia publication-title: Nat. Genet. doi: 10.1038/s41588-018-0129-5 – volume: 17 start-page: 193 year: 2012 end-page: 201 ident: CR10 article-title: Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain publication-title: Mol. Psychiatry doi: 10.1038/mp.2011.11 – volume: 36 start-page: 1417 year: 2006 end-page: 1426 ident: CR2 article-title: Recurrence risks for schizophrenia in a Swedish national cohort publication-title: Psychol. Med. doi: 10.1017/S0033291706008385 – volume: 32 start-page: 1479 year: 2016 end-page: 1485 ident: CR62 article-title: Fast and efficient QTL mapper for thousands of molecular phenotypes publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv722 – volume: 9 start-page: e1001046 year: 2011 ident: CR14 article-title: A user’s guide to the encyclopedia of DNA elements (ENCODE) publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1001046 – volume: 21 start-page: 1757 year: 2011 end-page: 1767 ident: CR24 article-title: Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity publication-title: Genome Res. doi: 10.1101/gr.121541.111 – ident: CR41 – volume: 397 start-page: 237 year: 2015 end-page: 247 ident: CR30 article-title: Sox21 regulates the progression of neuronal differentiation in a dose-dependent manner publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2014.11.012 – volume: 47 start-page: 11 year: 2014 end-page: 34 ident: CR60 article-title: BEDTools: The Swiss-Army Tool for genome feature analysis publication-title: Curr. Protoc. Bioinform. doi: 10.1002/0471250953.bi1112s47 – volume: 538 start-page: 523 year: 2016 end-page: 527 ident: CR12 article-title: Chromosome conformation elucidates regulatory relationships in developing human brain publication-title: Nature doi: 10.1038/nature19847 – volume: 530 start-page: 177 year: 2016 end-page: 183 ident: CR9 article-title: Schizophrenia risk from complex variation of complement component 4 publication-title: Nature doi: 10.1038/nature16549 – volume: 140 start-page: 552 year: 2013 ident: 5379_CR31 publication-title: Development doi: 10.1242/dev.085621 – ident: 5379_CR29 doi: 10.1016/j.celrep.2015.02.025 – volume: 9 start-page: e1001046 year: 2011 ident: 5379_CR14 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1001046 – volume: 26 start-page: 1942 year: 2017 ident: 5379_CR22 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddx103 – volume: 66 start-page: 377 year: 2009 ident: 5379_CR54 publication-title: Arch. Gen. Psychiatry doi: 10.1001/archgenpsychiatry.2009.10 – volume: 71 start-page: 255 year: 2014 ident: 5379_CR19 publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2013.3730 – volume: 161 start-page: 1012 year: 2015 ident: 5379_CR48 publication-title: Cell doi: 10.1016/j.cell.2015.04.004 – volume: 50 start-page: 381 year: 2018 ident: 5379_CR6 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0059-2 – volume: 166 start-page: 1269 year: 2016 ident: 5379_CR49 publication-title: Cell doi: 10.1016/j.cell.2016.07.049 – volume: 29 start-page: 2103 year: 2009 ident: 5379_CR33 publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2009.06768.x – volume: 17 start-page: 2042 year: 2016 ident: 5379_CR65 publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.10.061 – volume: 38 start-page: 17 year: 2003 ident: 5379_CR35 publication-title: Neuron doi: 10.1016/S0896-6273(03)00163-6 – volume: 19 start-page: 571 year: 2016 ident: 5379_CR7 publication-title: Nat. Neurosci. doi: 10.1038/nn.4267 – ident: 5379_CR51 doi: 10.3791/914 – volume: 530 start-page: 177 year: 2016 ident: 5379_CR9 publication-title: Nature doi: 10.1038/nature16549 – volume: 4 year: 2015 ident: 5379_CR56 publication-title: Gigascience doi: 10.1186/s13742-015-0047-8 – volume: 11 start-page: e1004219 year: 2015 ident: 5379_CR40 publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1004219 – ident: 5379_CR41 doi: 10.3390/cells6030026 – volume: 506 start-page: 179 year: 2014 ident: 5379_CR4 publication-title: Nature doi: 10.1038/nature12929 – volume: 10 start-page: 1213 year: 2013 ident: 5379_CR23 publication-title: Nat. Methods doi: 10.1038/nmeth.2688 – volume: 38 start-page: 1443 year: 2018 ident: 5379_CR38 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1641-17.2017 – volume: 17 start-page: 193 year: 2012 ident: 5379_CR10 publication-title: Mol. Psychiatry doi: 10.1038/mp.2011.11 – volume: 35 start-page: 561 year: 2017 ident: 5379_CR50 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3853 – volume: 7 year: 2016 ident: 5379_CR42 publication-title: Nat. Commun. doi: 10.1038/ncomms12230 – volume: 13 year: 2012 ident: 5379_CR52 publication-title: Genome Biol. doi: 10.1186/gb-2012-13-8-418 – ident: 5379_CR43 doi: 10.7554/eLife.12717 – volume: 175 start-page: 15 year: 2018 ident: 5379_CR1 publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2017.17030283 – volume: 518 start-page: 317 year: 2015 ident: 5379_CR15 publication-title: Nature doi: 10.1038/nature14248 – volume: 60 start-page: 1187 year: 2003 ident: 5379_CR3 publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.60.12.1187 – volume: 21 start-page: 1757 year: 2011 ident: 5379_CR24 publication-title: Genome Res. doi: 10.1101/gr.121541.111 – volume: 28 start-page: 495 year: 2010 ident: 5379_CR70 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1630 – volume: 465 start-page: 721 year: 2010 ident: 5379_CR17 publication-title: Nature doi: 10.1038/nature09230 – volume: 523 start-page: 486 year: 2015 ident: 5379_CR53 publication-title: Nature doi: 10.1038/nature14590 – volume: 32 start-page: 896 year: 2014 ident: 5379_CR68 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2931 – ident: 5379_CR5 doi: 10.1038/nature13595 – volume: 11 start-page: 11 10 11 year: 2013 ident: 5379_CR55 publication-title: Curr. Protoc. Bioinform. – volume: 100 start-page: 9440 year: 2003 ident: 5379_CR63 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1530509100 – volume: 25 start-page: 2078 year: 2009 ident: 5379_CR59 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 47 start-page: 1228 year: 2015 ident: 5379_CR25 publication-title: Nat. Genet. doi: 10.1038/ng.3404 – volume: 397 start-page: 237 year: 2015 ident: 5379_CR30 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2014.11.012 – volume: 57 start-page: 159 year: 1988 ident: 5379_CR21 publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.bi.57.070188.001111 – volume: 104 start-page: 9882 year: 2007 ident: 5379_CR39 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0701946104 – volume: 159 start-page: 1665 year: 2014 ident: 5379_CR27 publication-title: Cell doi: 10.1016/j.cell.2014.11.021 – volume: 47 start-page: 11 year: 2014 ident: 5379_CR60 publication-title: Curr. Protoc. Bioinform. doi: 10.1002/0471250953.bi1112s47 – volume: 17 start-page: R122 year: 2008 ident: 5379_CR67 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddn288 – volume: 115 start-page: 155 year: 2014 ident: 5379_CR18 publication-title: Int. Rev. Neurobiol. doi: 10.1016/B978-0-12-801311-3.00005-6 – volume: 34 start-page: 2921 year: 2014 ident: 5379_CR37 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2319-13.2014 – volume: 22 start-page: e190 year: 2006 ident: 5379_CR61 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0020190 – volume: 38 start-page: 576 year: 2010 ident: 5379_CR71 publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.05.004 – volume: 36 start-page: 1417 year: 2006 ident: 5379_CR2 publication-title: Psychol. Med. doi: 10.1017/S0033291706008385 – volume: 281 start-page: 21250 year: 2006 ident: 5379_CR28 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M600521200 – volume: 19 start-page: 1442 year: 2016 ident: 5379_CR11 publication-title: Nat. Neurosci. doi: 10.1038/nn.4399 – volume: 13 start-page: 539 year: 2012 ident: 5379_CR69 publication-title: Biostatistics doi: 10.1093/biostatistics/kxr034 – volume: 18 start-page: 1707 year: 2015 ident: 5379_CR16 publication-title: Nat. Neurosci. doi: 10.1038/nn.4156 – volume: 14 start-page: 45 year: 2011 ident: 5379_CR44 publication-title: Nat. Neurosci. doi: 10.1038/nn.2702 – volume: 9 start-page: 357 year: 2012 ident: 5379_CR58 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 – volume: 32 start-page: 1479 year: 2016 ident: 5379_CR62 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv722 – volume: 9 start-page: 1417 year: 2014 ident: 5379_CR13 publication-title: Cell Rep. doi: 10.1016/j.celrep.2014.10.015 – volume: 538 start-page: 523 year: 2016 ident: 5379_CR12 publication-title: Nature doi: 10.1038/nature19847 – volume: 18 start-page: 647 year: 2015 ident: 5379_CR47 publication-title: Nat. Neurosci. doi: 10.1038/nn.3995 – volume: 50 start-page: 825 year: 2018 ident: 5379_CR46 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0129-5 – volume: 24 start-page: 261 year: 2014 ident: 5379_CR32 publication-title: Cereb. Cortex doi: 10.1093/cercor/bhs307 – volume: 26 start-page: 205 year: 2004 ident: 5379_CR34 publication-title: Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2004.01.004 – volume: 482 start-page: 390 year: 2012 ident: 5379_CR45 publication-title: Nature doi: 10.1038/nature10808 – ident: 5379_CR8 doi: 10.1038/ng0417-651d – volume: 478 start-page: 476 year: 2011 ident: 5379_CR26 publication-title: Nature doi: 10.1038/nature10530 – volume: 15 year: 2014 ident: 5379_CR66 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 8 year: 2007 ident: 5379_CR36 publication-title: Genome Biol. doi: 10.1186/gb-2007-8-5-r72 – ident: 5379_CR57 doi: 10.14806/ej.17.1.200 – volume: 19 start-page: 40 year: 2016 ident: 5379_CR20 publication-title: Nat. Neurosci. doi: 10.1038/nn.4181 – volume: 10 start-page: e1004383 year: 2014 ident: 5379_CR64 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004383
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Snippet	Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding... Chromatin accessibility may be altered in disease states. Here the authors carry out ATAC-seq on a large number of samples of dorsolateral prefrontal cortex...
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SubjectTerms	13 38 45 631/337/100/102 631/378/1689/1799 Accessibility Age Aged Aged, 80 and over Brain Brain - physiopathology Chromatin Chromatin - chemistry Conserved sequence Female Gene Expression Profiling Gene mapping Genome-wide association studies Genome-Wide Association Study Genomes Health risks Heritability High-Throughput Nucleotide Sequencing Humanities and Social Sciences Humans Male Mental disorders Middle Aged multidisciplinary Mutation Non-coding RNA Polymorphism, Single Nucleotide Prefrontal cortex Prefrontal Cortex - metabolism Quantitative Trait Loci Regulatory sequences Risk Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Science Science (multidisciplinary) Sequence Analysis, DNA
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Title	Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia
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