Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

The innate immune response to bacterial infections requires the interaction of neutrophils and platelets. Here, we show that a multistep reciprocal crosstalk exists between these two cell types, ultimately facilitating neutrophil influx into the lung to eliminate infections. Activated platelets adhe...

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Bibliographic Details
Published in:	Nature communications Vol. 7; no. 1; pp. 13464 - 14
Main Authors:	Rossaint, Jan, Kühne, Katharina, Skupski, Jennifer, Van Aken, Hugo, Looney, Mark R., Hidalgo, Andres, Zarbock, Alexander
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.11.2016 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/31 14/19 14/63 631/250/2504/223/1699 631/443/592/1339 64/60 Acids Animals Bacterial diseases Bacterial infections Biological Transport - immunology Blood Platelets - immunology Blood Platelets - metabolism Cyclooxygenase 1 - genetics Cyclooxygenase 1 - immunology Cyclooxygenase 1 - metabolism Escherichia coli Infections - genetics Escherichia coli Infections - immunology Escherichia coli Infections - metabolism Extracellular vesicles Extracellular Vesicles - immunology Extracellular Vesicles - metabolism Glycoproteins Humanities and Social Sciences Immune response Immunity - immunology Male Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Metabolism Metabolites Mice, Inbred C57BL Mice, Knockout multidisciplinary Neutrophils Neutrophils - immunology Neutrophils - metabolism P-Selectin - immunology P-Selectin - metabolism Platelet Adhesiveness - immunology Platelet Glycoprotein GPIb-IX Complex - immunology Platelet Glycoprotein GPIb-IX Complex - metabolism Pneumonia Pneumonia, Bacterial - genetics Pneumonia, Bacterial - immunology Pneumonia, Bacterial - metabolism Science Science (multidisciplinary) Thromboxane A2 - immunology Thromboxane A2 - metabolism United States > US Germany California
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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