NK cells are activated and primed for skin-homing during acute dengue virus infection in humans

Despite animal models showing that natural killer (NK) cells are important players in the early defense against many viral infections, the NK cell response is poorly understood in humans. Here we analyze the phenotype, temporal dynamics, regulation and trafficking of NK cells in a patient cohort wit...

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Veröffentlicht in:	Nature communications Jg. 10; H. 1; S. 3897 - 15
Hauptverfasser:	Zimmer, Christine L., Cornillet, Martin, Solà-Riera, Carles, Cheung, Ka-Wai, Ivarsson, Martin A., Lim, Mei Qiu, Marquardt, Nicole, Leo, Yee-Sin, Lye, David Chien, Klingström, Jonas, MacAry, Paul A., Ljunggren, Hans-Gustaf, Rivino, Laura, Björkström, Niklas K.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 29.08.2019 Nature Publishing Group Nature Portfolio
Schlagworte:	13 13/21 13/31 631/250/127/1213 631/250/2504/2506 631/250/255/2514 631/250/516 Animal models Animals Antigens, CD Antigens, Differentiation, T-Lymphocyte Blistering Blisters CD56 Antigen - genetics Cell Proliferation Chemokines Dengue - immunology Dengue fever Dengue Virus Homing Humanities and Social Sciences Humans Infections Interleukin 18 Interleukin-18 - metabolism Killer Cells, Natural - immunology Lectins, C-Type Lymphocyte Activation Mice multidisciplinary Natural killer cells Phenotype Phenotypes Priming Receptors, CCR5 Receptors, CXCR3 Receptors, Interleukin-18 - metabolism Science Science (multidisciplinary) Signal Transduction Skin Skin - immunology Vector-borne diseases Viral diseases Viral infections Viruses
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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