Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women

Objectives Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control...

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Vydáno v:	Cancer causes & control Ročník 21; číslo 6; s. 897 - 908
Hlavní autoři:	Lin, Jennifer, Zee, Robert Y. L, Liu, Kuang-Yu, Zhang, Shumin M, Lee, I-Min, Manson, JoAnn E, Giovannucci, Edward, Buring, Julie E, Cook, Nancy R
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Dordrecht Dordrecht : Springer Netherlands 01.06.2010 Springer Springer Netherlands Springer Nature B.V
Témata:	Aged Ambulatory care Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Cardiovascular disease Colorectal cancer colorectal neoplasms Colorectal Neoplasms - genetics CYP19A1 Cytochrome Dehydrogenases Disease prevention Endocrine therapy Enzymes Epidemiology Estradiol Dehydrogenases Estradiol Dehydrogenases - genetics Estrogen receptors Estrogens Ethnicity Ethnicity - genetics Female Females Genes Genetic loci Genetic Variation Genetic Variation - genetics genetics Gonadal Steroid Hormones Gonadal Steroid Hormones - genetics Haplotypes Health care Hematology Hormones Hospitals HSD17B2 Humans Logistic Models Middle Aged Odds Ratio Oncology Original Paper Polymorphism, Single Nucleotide Postmenopause Preventive medicine Progesterone receptor Public Health Receptors Receptors, Estrogen Receptors, Estrogen - genetics Receptors, Progesterone Receptors, Progesterone - genetics Receptors, Steroid Receptors, Steroid - genetics Risk Factors Sex hormone genes Sex hormones Steroids Tumors White People White People - genetics Womens health United States > US Estrogen receptors Sex hormone genes Progesterone receptor CYP19A1 Colorectal cancer HSD17B2
ISSN:	0957-5243, 1573-7225, 1573-7225
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