Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women
Objectives Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control...
Gespeichert in:
| Veröffentlicht in: | Cancer causes & control Jg. 21; H. 6; S. 897 - 908 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Dordrecht
Dordrecht : Springer Netherlands
01.06.2010
Springer Springer Netherlands Springer Nature B.V |
| Schlagworte: | |
| ISSN: | 0957-5243, 1573-7225, 1573-7225 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Objectives Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 and ESR2), progesterone receptor (PGR), aromatase cytochrome 450 enzyme (CYP19A1), and 17 beta-hydroxysteroid dehydrogenase type 2 gene (HSD17B2). Methods We included 158 incident cases of colorectal cancer and 563 randomly chosen control subjects from 28,345 women in the Women's Health Study aged 45 or older who provided blood samples and had no history of cancer or cardiovascular disease at baseline in 1993. All cases and controls were Caucasians of European descent. A total of 63 tagging and putative functional SNPs in the 5 genes were included for analysis. Unconditional logistic regression was used to estimate odds ratio (ORs) and 95% confidence intervals (CIs). Results There was no association between variation in ESR1, ESR2, PGR, CYP19A1 and HSD17B2 and colorectal cancer risk after correction for multiple comparisons (p values after correction ≥0.25). There was also no association with any of the haplotypes examined (p ≥ 0.15) and no evidence of joint effects of variants in the 5 genes (p ≥ 0.51). Conclusion Our data offer insufficient support for an association between variation in ESR1, ESR2, PGR, CYP19A1, and HSD17B2 and risk for developing colorectal cancer. |
|---|---|
| AbstractList | Objectives Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 and ESR2), progesterone receptor (PGR), aromatase cytochrome 450 enzyme (CYP19A1), and 17 beta-hydroxysteroid dehydrogenase type 2 gene (HSD17B2). Methods We included 158 incident cases of colorectal cancer and 563 randomly chosen control subjects from 28,345 women in the Women's Health Study aged 45 or older who provided blood samples and had no history of cancer or cardiovascular disease at baseline in 1993. All cases and controls were Caucasians of European descent. A total of 63 tagging and putative functional SNPs in the 5 genes were included for analysis. Unconditional logistic regression was used to estimate odds ratio (ORs) and 95% confidence intervals (CIs). Results There was no association between variation in ESR1, ESR2, PGR, CYP19A1 and HSD17B2 and colorectal cancer risk after correction for multiple comparisons (p values after correction ≥0.25). There was also no association with any of the haplotypes examined (p ≥ 0.15) and no evidence of joint effects of variants in the 5 genes (p ≥ 0.51). Conclusion Our data offer insufficient support for an association between variation in ESR1, ESR2, PGR, CYP19A1, and HSD17B2 and risk for developing colorectal cancer. Objectives: Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 and ESR2), progesterone receptor (PGR), aromatase cytochrome 450 enzyme (CYP19A1), and 17 beta-hydroxysteroid dehydrogenase type 2 gene (HSD17B2). Methods: We included 158 incident cases of colorectal cancer and 563 randomly chosen control subjects from 28,345 women in the Women's Health Study aged 45 or older who provided blood samples and had no history of cancer or cardiovascular disease at baseline in 1993. All cases and controls were Caucasians of European descent. A total of 63 tagging and putative functional SNPs in the 5 genes were included for analysis. Unconditional logistic regression was used to estimate odds ratio (ORs) and 95% confidence intervals (CIs). Results: There was no association between variation in ESR1, ESR2, PGR, CYP19A1 and HSD17B2 and colorectal cancer risk after correction for multiple comparisons (p values after correction .0.25). There was also no association with any of the haplotypes examined (p.0.15) and no evidence of joint effects of variants in the 5 genes (p.0.51). Conclusion: Our data offer insufficient support for an association between variation in ESR1, ESR2, PGR, CYP19A1, and HSD17B2 and risk for developing colorectal cancer. Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 and ESR2), progesterone receptor (PGR), aromatase cytochrome 450 enzyme (CYP19A1), and 17 beta-hydroxysteroid dehydrogenase type 2 gene (HSD17B2). We included 158 incident cases of colorectal cancer and 563 randomly chosen control subjects from 28,345 women in the Women's Health Study aged 45 or older who provided blood samples and had no history of cancer or cardiovascular disease at baseline in 1993. All cases and controls were Caucasians of European descent. A total of 63 tagging and putative functional SNPs in the 5 genes were included for analysis. Unconditional logistic regression was used to estimate odds ratio (ORs) and 95% confidence intervals (CIs). There was no association between variation in ESR1, ESR2, PGR, CYP19A1 and HSD17B2 and colorectal cancer risk after correction for multiple comparisons (p values after correction ≥0.25). There was also no association with any of the haplotypes examined (p ≥ 0.15) and no evidence of joint effects of variants in the 5 genes (p ≥ 0.51). Our data offer insufficient support for an association between variation in ESR1, ESR2, PGR, CYP19A1, and HSD17B2 and risk for developing colorectal cancer.[PUBLICATION ABSTRACT] Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 and ESR2), progesterone receptor (PGR), aromatase cytochrome 450 enzyme (CYP19A1), and 17 beta-hydroxysteroid dehydrogenase type 2 gene (HSD17B2). We included 158 incident cases of colorectal cancer and 563 randomly chosen control subjects from 28,345 women in the Women's Health Study aged 45 or older who provided blood samples and had no history of cancer or cardiovascular disease at baseline in 1993. All cases and controls were Caucasians of European descent. A total of 63 tagging and putative functional SNPs in the 5 genes were included for analysis. Unconditional logistic regression was used to estimate odds ratio (ORs) and 95% confidence intervals (CIs). There was no association between variation in ESR1, ESR2, PGR, CYP19A1 and HSD17B2 and colorectal cancer risk after correction for multiple comparisons (p values after correction > or =0.25). There was also no association with any of the haplotypes examined (p > or = 0.15) and no evidence of joint effects of variants in the 5 genes (p > or = 0.51). Our data offer insufficient support for an association between variation in ESR1, ESR2, PGR, CYP19A1, and HSD17B2 and risk for developing colorectal cancer. Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 and ESR2), progesterone receptor (PGR), aromatase cytochrome 450 enzyme (CYP19A1), and 17 beta-hydroxysteroid dehydrogenase type 2 gene (HSD17B2).OBJECTIVESSeveral lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 and ESR2), progesterone receptor (PGR), aromatase cytochrome 450 enzyme (CYP19A1), and 17 beta-hydroxysteroid dehydrogenase type 2 gene (HSD17B2).We included 158 incident cases of colorectal cancer and 563 randomly chosen control subjects from 28,345 women in the Women's Health Study aged 45 or older who provided blood samples and had no history of cancer or cardiovascular disease at baseline in 1993. All cases and controls were Caucasians of European descent. A total of 63 tagging and putative functional SNPs in the 5 genes were included for analysis. Unconditional logistic regression was used to estimate odds ratio (ORs) and 95% confidence intervals (CIs).METHODSWe included 158 incident cases of colorectal cancer and 563 randomly chosen control subjects from 28,345 women in the Women's Health Study aged 45 or older who provided blood samples and had no history of cancer or cardiovascular disease at baseline in 1993. All cases and controls were Caucasians of European descent. A total of 63 tagging and putative functional SNPs in the 5 genes were included for analysis. Unconditional logistic regression was used to estimate odds ratio (ORs) and 95% confidence intervals (CIs).There was no association between variation in ESR1, ESR2, PGR, CYP19A1 and HSD17B2 and colorectal cancer risk after correction for multiple comparisons (p values after correction > or =0.25). There was also no association with any of the haplotypes examined (p > or = 0.15) and no evidence of joint effects of variants in the 5 genes (p > or = 0.51).RESULTSThere was no association between variation in ESR1, ESR2, PGR, CYP19A1 and HSD17B2 and colorectal cancer risk after correction for multiple comparisons (p values after correction > or =0.25). There was also no association with any of the haplotypes examined (p > or = 0.15) and no evidence of joint effects of variants in the 5 genes (p > or = 0.51).Our data offer insufficient support for an association between variation in ESR1, ESR2, PGR, CYP19A1, and HSD17B2 and risk for developing colorectal cancer.CONCLUSIONOur data offer insufficient support for an association between variation in ESR1, ESR2, PGR, CYP19A1, and HSD17B2 and risk for developing colorectal cancer. Objectives Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 and ESR2), progesterone receptor (PGR), aromatase cytochrome 450 enzyme (CYP19A1), and 17 beta-hydroxysteroid dehydrogenase type 2 gene (HSD17B2). Methods We included 158 incident cases of colorectal cancer and 563 randomly chosen control subjects from 28,345 women in the Women’s Health Study aged 45 or older who provided blood samples and had no history of cancer or cardiovascular disease at baseline in 1993. All cases and controls were Caucasians of European descent. A total of 63 tagging and putative functional SNPs in the 5 genes were included for analysis. Unconditional logistic regression was used to estimate odds ratio (ORs) and 95% confidence intervals (CIs). Results There was no association between variation in ESR1, ESR2, PGR, CYP19A1 and HSD17B2 and colorectal cancer risk after correction for multiple comparisons ( p values after correction ≥0.25). There was also no association with any of the haplotypes examined ( p ≥ 0.15) and no evidence of joint effects of variants in the 5 genes ( p ≥ 0.51). Conclusion Our data offer insufficient support for an association between variation in ESR1, ESR2, PGR, CYP19A1, and HSD17B2 and risk for developing colorectal cancer. |
| Author | Manson, JoAnn E. Lee, I-Min Giovannucci, Edward Cook, Nancy R. Zhang, Shumin M. Lin, Jennifer Zee, Robert Y. L. Liu, Kuang-Yu Buring, Julie E. |
| AuthorAffiliation | 2 Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 3 Department of Epidemiology, Harvard School of Public Health, Boston, MA 1 Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 5 Department of Ambulatory Care and Prevention, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 4 Department of Nutrition, Harvard School of Public Health, Boston, MA |
| AuthorAffiliation_xml | – name: 2 Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA – name: 4 Department of Nutrition, Harvard School of Public Health, Boston, MA – name: 1 Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA – name: 3 Department of Epidemiology, Harvard School of Public Health, Boston, MA – name: 5 Department of Ambulatory Care and Prevention, Brigham and Women's Hospital and Harvard Medical School, Boston, MA |
| Author_xml | – sequence: 1 fullname: Lin, Jennifer – sequence: 2 fullname: Zee, Robert Y. L – sequence: 3 fullname: Liu, Kuang-Yu – sequence: 4 fullname: Zhang, Shumin M – sequence: 5 fullname: Lee, I-Min – sequence: 6 fullname: Manson, JoAnn E – sequence: 7 fullname: Giovannucci, Edward – sequence: 8 fullname: Buring, Julie E – sequence: 9 fullname: Cook, Nancy R |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20148360$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkjtvFDEUhS0URDaBH0ABjNJQDVy_Z5pIKIKAFIkCUlse752Nl1l7sWcDm18fL5MESBGoXNzvHN_HOSB7IQYk5DmFNxRAv80UpGQ1UKhbSZtaPiIzKjWvNWNyj8yglbqWTPB9cpDzEgCkYvCE7DOgouEKZmRxigFH76pLm7wdfQyVD1XGn3UeMUU_rxI6XI8x5cqGeZW3YbzA7K98WFQYrrYrnAouDrGgox0qZ4PDVCWfv-3MfsQVhqfkcW-HjM9u3kNy_uH915OP9dnn008n785qJ3Uz1rTvHHNaCHC90s4xjh22LYKynDOqO9rLvseetg1yrtTcdWJeECc76Fst-SE5nnzXm26Fc4dhTHYw6-RXNm1NtN78XQn-wizipWGN5lS0xeD1jUGK3zeYR7Py2eEw2IBxk40WUpVWmv8hmQbGgf-b5FyycjJayKN75DJuUigbM4xy0IoLUaCXf854N9ztVQugJ8ClmHPC3jg__jpuGdkPhoLZ5cdM-TElP2aXH7NbH72nvDV_SMMmTS5sWGD63fNDoheTaJlLtu5-EaDKfhtV6q-mem-jsYuSJXP-pQzIgTaCtkrzawt_6_c |
| CODEN | CCCNEN |
| CitedBy_id | crossref_primary_10_1186_1471_2350_12_78 crossref_primary_10_1016_j_gene_2019_06_017 crossref_primary_10_1007_s00384_012_1628_y crossref_primary_10_1038_s41598_022_22973_9 crossref_primary_10_1007_s10552_011_9768_x crossref_primary_10_1097_GME_0b013e31829e498d crossref_primary_10_1016_j_clinre_2014_07_016 crossref_primary_10_3389_fimmu_2023_1301452 crossref_primary_10_1093_jnci_djac094 crossref_primary_10_1158_0008_5472_CAN_12_2484 crossref_primary_10_1038_bjc_2015_443 crossref_primary_10_1007_s00384_012_1505_8 crossref_primary_10_1371_journal_pone_0169266 |
| Cites_doi | 10.1046/j.1365-2796.1999.00545.x 10.1023/A:1008879920140 10.1038/ng.133 10.1002/(SICI)1096-9098(199912)72:4<225::AID-JSO8>3.0.CO;2-S 10.1136/gut.37.6.737 10.1158/0008-5472.CAN-07-2946 10.1086/303069 10.1210/en.138.9.4030 10.1038/nature05887 10.1002/ijc.23127 10.1093/bioinformatics/btf869 10.1677/erc.1.01038 10.1534/genetics.104.036699 10.1158/0008-5472.CAN-06-3591 10.1093/hmg/ddg294 10.1093/bioinformatics/bth457 10.1586/14737159.4.6.795 10.1038/ng2085 10.1038/ng.2007.41 10.1158/0008-5472.CAN-06-4123 10.1038/ng.2007.18 10.1001/jama.291.14.1775 10.1136/gut.34.5.611 10.1158/1055-9965.EPI-08-0777 10.1677/joe.1.05770 10.1038/ng0894-536 10.1136/gut.51.2.147 10.1093/jnci/87.7.517 10.1038/ng2089 10.1038/ng2064 10.1016/S0960-0760(99)00144-2 10.1002/1097-0142(19851201)56:11<2627::AID-CNCR2820561116>3.0.CO;2-J 10.1002/gepi.20061 10.1093/jnci/90.17.1292 10.1159/000057986 10.1002/gepi.10218 10.3322/CA.2007.0010 10.1038/ng.318 10.1186/1471-2407-7-123 10.1093/hmg/ddn429 10.1093/carcin/17.1.95 10.1038/ng.111 10.1158/1055-9965.EPI-05-0514 10.1001/jama.288.3.321 10.1038/ng.353 10.1016/S0959-8049(01)00139-3 10.1038/ng2075 10.1056/NEJM200101253440407 10.1007/BF02048105 10.1093/jnci/djh167 10.1093/oxfordjournals.aje.a115165 10.1016/S0021-9258(19)47313-4 10.7326/0003-4819-142-6-200503150-00008 10.1093/jnci/dji007 10.1093/oxfordjournals.aje.a009059 10.1093/jnci/53.4.1093 10.1093/carcin/bgp273 10.1210/endo.138.9.5489 |
| ContentType | Journal Article |
| Copyright | 2010 Springer Springer Science+Business Media B.V. 2010 |
| Copyright_xml | – notice: 2010 Springer – notice: Springer Science+Business Media B.V. 2010 |
| DBID | FBQ AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7RV 7TO 7X7 7XB 88E 8AO 8C1 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH H94 K9. KB0 M0S M1P NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 7S9 L.6 7U1 C1K 5PM |
| DOI | 10.1007/s10552-010-9518-5 |
| DatabaseName | AGRIS CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Oncogenes and Growth Factors Abstracts Health & Medical Collection (ProQuest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central ProQuest One Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Health & Medical Collection Medical Database Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic AGRICOLA AGRICOLA - Academic Risk Abstracts Environmental Sciences and Pollution Management PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Oncogenes and Growth Factors Abstracts ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic AGRICOLA AGRICOLA - Academic Risk Abstracts Environmental Sciences and Pollution Management |
| DatabaseTitleList | Risk Abstracts AGRICOLA Oncogenes and Growth Factors Abstracts MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Public Health |
| EISSN | 1573-7225 |
| EndPage | 908 |
| ExternalDocumentID | PMC2873149 2034364641 20148360 10_1007_s10552_010_9518_5 40645686 US201301841967 |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | United States--US |
| GeographicLocations_xml | – name: United States--US |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: R01 HL043851 – fundername: NHLBI NIH HHS grantid: R01 HL080467 – fundername: NHLBI NIH HHS grantid: HL080467 – fundername: NCI NIH HHS grantid: K07 CA112529 – fundername: NCI NIH HHS grantid: R01 CA047988 – fundername: NCI NIH HHS grantid: CA47988 – fundername: NCI NIH HHS grantid: CA112529 – fundername: NHLBI NIH HHS grantid: HL43851 |
| GroupedDBID | --- -4W -5E -5G -BR -EM -Y2 -~C .86 .VR 04C 06C 06D 0R~ 0VY 199 1N0 1SB 203 28- 29B 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3SX 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5RE 5VS 67Z 6NX 78A 7RV 7X7 88E 8AO 8C1 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AABYN AACGO AAFGU AAHNG AAIAL AAJKR AANCE AANXM AANZL AARHV AARTL AATNV AATVU AAUYE AAWCG AAWTL AAYFA AAYIU AAYQN AAYTO ABBBX ABBHK ABBXA ABDZT ABECU ABELW ABFGW ABFTV ABHLI ABHQN ABIPD ABIVO ABJNI ABJOX ABKAS ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABPLY ABQBU ABSXP ABTEG ABTHY ABTKH ABTLG ABTMW ABULA ABUWG ABWNU ABXPI ACBMV ACBRV ACBYP ACGFS ACHSB ACHVE ACHXU ACIGE ACIPQ ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACTTH ACVWB ACWMK ADBBV ADHHG ADHIR ADIMF ADINQ ADJJI ADKNI ADKPE ADMDM ADOAH ADOXG ADRFC ADTPH ADULT ADURQ ADYFF ADYPR ADZKW ADZLD AEBTG AEEQQ AEFIE AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AENEX AEOHA AEPYU AESKC AESTI AETLH AEUPB AEVLU AEVTX AEXYK AEXZC AFEXP AFKRA AFLOW AFNRJ AFQWF AFRAH AFWTZ AFZKB AGAYW AGDGC AGGBP AGGDS AGJBK AGMZJ AGQMX AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHKAY AHMBA AHSBF AHYZX AIAKS AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AJZVZ AKMHD AKQUC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG AOSHJ ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBWZM BDATZ BENPR BGNMA BKEYQ BMSDO BPHCQ BVXVI CAG CCPQU COF CS3 CSCUP DCCCD DDRTE DL5 DNIVK DNJUQ DOOOF DPUIP DU5 DWIUU EBD EBLON EBS EIHBH EIOEI EJD EMB EMOBN EN4 EPAXT ESBYG EX3 F3I F5P FBQ FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GXS HF~ HG5 HG6 HGD HMCUK HMJXF HQ3 HQYDN HRMNR HTVGU HVGLF HZ~ I09 IHE IJ- IKXTQ IMOTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JAAYA JBMMH JBSCW JCJTX JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST JZLTJ KDC KOV KOW KPH LAK LLZTM M1P M4Y MA- N2Q NAPCQ NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P P9S PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S37 S3B SA0 SAP SBY SCLPG SDH SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TEORI TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK6 WK8 WOW YLTOR Z45 Z7U Z7W Z81 Z82 Z83 Z87 Z8O Z8V Z91 ZMTXR ZOVNA ~A9 ~EX ~KM AACDK AAJBT AAPKM AASML AAYZH ABAKF ABBRH ABDBE ABFSG ABQSL ABXSQ ACAOD ACDTI ACHIC ACPIV ACSTC ACZOJ ADHKG ADQXQ AEFQL AEMSY AEZWR AFBBN AFDZB AFHIU AGQEE AGQPQ AGRTI AHPBZ AHWEU AIGIU AIXLP ALIPV AQVQM ATHPR AYFIA BSONS H13 IPSME PHGZM PHGZT AAYXX ABRTQ AFFHD AFOHR CITATION PJZUB PPXIY CGR CUY CVF ECM EIF NPM 7TO 7XB 8FK H94 K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 7S9 L.6 7U1 C1K 5PM |
| ID | FETCH-LOGICAL-c578t-1fbc2c7440cf67cc23ebe99e06a33217b1f5ffef198e3366dcb4debec5b0f9753 |
| IEDL.DBID | 7RV |
| ISICitedReferencesCount | 17 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000277709800012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0957-5243 1573-7225 |
| IngestDate | Tue Nov 04 01:55:33 EST 2025 Tue Oct 07 09:36:00 EDT 2025 Sun Nov 09 09:10:27 EST 2025 Thu Oct 02 04:08:35 EDT 2025 Sat Nov 08 14:28:33 EST 2025 Mon Jul 21 05:54:43 EDT 2025 Sat Nov 29 04:22:09 EST 2025 Tue Nov 18 21:56:38 EST 2025 Fri Feb 21 02:40:54 EST 2025 Thu Jun 19 15:51:11 EDT 2025 Wed Dec 27 19:14:59 EST 2023 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Estrogen receptors Sex hormone genes Progesterone receptor CYP19A1 Colorectal cancer HSD17B2 |
| Language | English |
| License | http://www.springer.com/tdm |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c578t-1fbc2c7440cf67cc23ebe99e06a33217b1f5ffef198e3366dcb4debec5b0f9753 |
| Notes | http://dx.doi.org/10.1007/s10552-010-9518-5 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41392046 |
| PMID | 20148360 |
| PQID | 213076344 |
| PQPubID | 31057 |
| PageCount | 12 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2873149 proquest_miscellaneous_745633289 proquest_miscellaneous_742702303 proquest_miscellaneous_733522251 proquest_journals_213076344 pubmed_primary_20148360 crossref_citationtrail_10_1007_s10552_010_9518_5 crossref_primary_10_1007_s10552_010_9518_5 springer_journals_10_1007_s10552_010_9518_5 jstor_primary_40645686 fao_agris_US201301841967 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-06-01 |
| PublicationDateYYYYMMDD | 2010-06-01 |
| PublicationDate_xml | – month: 06 year: 2010 text: 2010-06-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Dordrecht |
| PublicationPlace_xml | – name: Dordrecht – name: Netherlands |
| PublicationSubtitle | An International Journal of Studies of Cancer in Human Populations |
| PublicationTitle | Cancer causes & control |
| PublicationTitleAbbrev | Cancer Causes Control |
| PublicationTitleAlternate | Cancer Causes Control |
| PublicationYear | 2010 |
| Publisher | Dordrecht : Springer Netherlands Springer Springer Netherlands Springer Nature B.V |
| Publisher_xml | – name: Dordrecht : Springer Netherlands – name: Springer – name: Springer Netherlands – name: Springer Nature B.V |
| References | Issa, Ottaviano, Celano, Hamilton, Davidson, Baylin (CR22) 1994; 7 Gilad, Bresler, Gnainsky, Smirnoff, Schwartz (CR66) 2005; 185 Speer, Cseh, Winkler, Takacs, Barna, Nagy (CR31) 2001; 37 Jassam, Bell, Speirs, Quirke (CR21) 2005; 14 Odagiri, Jibiki, Kato, Nakamura, Oda, Demura (CR4) 1985; 56 Oshima, Wonraht, Catarino, Mattos, Forones (CR25) 1999; 46 Tenesa, Farrington, Prendergast, Porteous, Walker, Haq (CR37) 2008; 40 Clendenen, Koenig, Shore, Levitz, Arslan, Zeleniuch-Jacquotte (CR16) 2009; 18 Cox, Bretsky, Kraft, Pharoah, Albanes, Altshuler (CR44) 2008; 122 Zhang, Buring, Lee, Cook, Ridker (CR40) 2005; 142 Rossouw, Anderson, Prentice, LaCroix, Kooperberg, Stefanick (CR13) 2002; 288 Clemons, Goss (CR30) 2001; 344 Watters, Campbell, Cunningham, Krebs, Dorsa (CR65) 1997; 138 Berta, Fronticelli Baldelli, Fazzari, Radice, Bargoni, Frairia (CR26) 2003; 45 Barrett, Fry, Maller, Daly (CR41) 2005; 21 Hankinson, Willett, Manson, Colditz, Hunter, Spiegelman (CR52) 1998; 90 Schumacher, Feigelson, Cox, Haiman, Albanes, Buring (CR59) 2007; 67 Dunning, Dowsett, Healey, Tee, Luben, Folkerd (CR56) 2004; 96 Froggatt, Green, Brassett, Evans, Bishop, Kolodner (CR2) 1999; 36 Tomlinson, Webb, Carvajal-Carmona, Broderick, Howarth, Pittman (CR36) 2008; 40 Thomas, Jacobs, Kraft, Yeager, Wacholder, Cox (CR61) 2009; 41 Gunter, Hoover, Yu, Wassertheil-Smoller, Rohan, Manson (CR15) 2008; 68 Hunter, Kraft, Jacobs, Cox, Yeager, Hankinson (CR58) 2007; 39 McMichael, Potter (CR12) 1980; 65 Haiman, Stram, Pike, Kolonel, Burtt, Altshuler (CR42) 2003; 12 Di Leo, Linsalata, Cavallini, Messa, Russo (CR23) 1992; 35 Singh, Sheppard, Langman (CR24) 1993; 34 Ochiai, Watanabe, Kushida, Wakabayashi, Sugimura, Nagao (CR3) 1996; 17 Zheng, Long, Gao, Li, Zheng, Xiang (CR62) 2009; 41 Means, Mahendroo, Corbin, Mathis, Powell, Mendelson (CR29) 1989; 264 Zeleniuch-Jacquotte, Bruning, Bonfrer, Koenig, Shore, Kim (CR53) 1997; 145 Jaeger, Webb, Howarth, Carvajal-Carmona, Rowan, Broderick (CR38) 2008; 40 Moore (CR50) 2004; 4 Gershbein (CR5) 1993; 81 Bethke, Webb, Sellick, Rudd, Penegar, Withey (CR33) 2007; 7 Kune, Kune, Watson (CR8) 1989; 129 Narisawa, Magadia, Weisburger, Wynder (CR10) 1974; 53 Kaklamanos, Bathe, Franceschi, Lazaris, Davaris, Glinatsis (CR27) 1999; 72 Anderson, Limacher, Assaf, Bassford, Beresford, Black (CR14) 2004; 291 Pearce, Hirschhorn, Wu, Burtt, Stram, Young (CR43) 2005; 97 Fiorelli, Picariello, Martineti, Tonelli, Brandi (CR28) 1999; 71 Easton, Pooley, Dunning, Pharoah, Thompson, Ballinger (CR57) 2007; 447 Dunning, Healey, Baynes, Maia, Scollen, Vega (CR63) 2009; 18 Calle, Miracle-McMahill, Thun, Heath (CR6) 1995; 87 Zanke, Greenwood, Rangrej, Kustra, Tenesa, Farrington (CR35) 2007; 39 Broderick, Carvajal-Carmona, Pittman, Webb, Howarth, Rowan (CR39) 2007; 39 Enmark, Gustafsson (CR18) 1999; 246 Kraft, Cox, Paynter, Hunter, De Vivo (CR47) 2005; 28 Zaykin, Westfall, Young, Karnoub, Wagner, Ehm (CR46) 2002; 53 Kaaks, Rinaldi, Key, Berrino, Peeters, Biessy (CR54) 2005; 12 Haiman, Dossus, Setiawan, Stram, Dunning, Thomas (CR55) 2007; 67 Hahn, Ritchie, Moore (CR49) 2003; 19 Fallin, Schork (CR45) 2000; 67 Slattery, Sweeney, Murtaugh, Ma, Wolff, Potter (CR32) 2005; 14 Benjamini, Yekutieli (CR51) 2005; 171 McMichael, Potter (CR11) 1985; 75 Tomlinson, Webb, Carvajal-Carmona, Broderick, Kemp, Spain (CR34) 2007; 39 Jemal, Siegel, Ward, Hao, Xu, Murray (CR1) 2008; 58 CR64 Singh, Langman (CR9) 1995; 37 Stacey, Manolescu, Sulem, Rafnar, Gudmundsson, Gudjonsson (CR60) 2007; 39 Campbell-Thompson, Lynch, Bhardwaj (CR19) 2001; 61 Giovannucci (CR17) 2002; 51 Ritchie, Hahn, Moore (CR48) 2003; 24 Kono, Honjo, Todoroki, Nishiwaki, Hamada, Nishikawa (CR20) 1998; 9 Potter, McMichael (CR7) 1983; 71 AM Dunning (9518_CR56) 2004; 96 SN Stacey (9518_CR60) 2007; 39 JE Rossouw (9518_CR13) 2002; 288 L Berta (9518_CR26) 2003; 45 E Jaeger (9518_CR38) 2008; 40 P Kraft (9518_CR47) 2005; 28 JJ Watters (9518_CR65) 1997; 138 W Zheng (9518_CR62) 2009; 41 M Clemons (9518_CR30) 2001; 344 SE Hankinson (9518_CR52) 1998; 90 IP Tomlinson (9518_CR36) 2008; 40 LW Hahn (9518_CR49) 2003; 19 JP Issa (9518_CR22) 1994; 7 MJ Gunter (9518_CR15) 2008; 68 T Narisawa (9518_CR10) 1974; 53 DF Easton (9518_CR57) 2007; 447 EE Calle (9518_CR6) 1995; 87 CA Haiman (9518_CR42) 2003; 12 R Kaaks (9518_CR54) 2005; 12 A Tenesa (9518_CR37) 2008; 40 LA Gilad (9518_CR66) 2005; 185 N Jassam (9518_CR21) 2005; 14 JC Barrett (9518_CR41) 2005; 21 G Thomas (9518_CR61) 2009; 41 L Bethke (9518_CR33) 2007; 7 GA Kune (9518_CR8) 1989; 129 AJ McMichael (9518_CR12) 1980; 65 M Campbell-Thompson (9518_CR19) 2001; 61 A Di Leo (9518_CR23) 1992; 35 MD Ritchie (9518_CR48) 2003; 24 E Enmark (9518_CR18) 1999; 246 CT Oshima (9518_CR25) 1999; 46 CA Haiman (9518_CR55) 2007; 67 9518_CR64 LL Gershbein (9518_CR5) 1993; 81 SM Zhang (9518_CR40) 2005; 142 IG Kaklamanos (9518_CR27) 1999; 72 S Singh (9518_CR9) 1995; 37 G Speer (9518_CR31) 2001; 37 D Fallin (9518_CR45) 2000; 67 GL Anderson (9518_CR14) 2004; 291 E Giovannucci (9518_CR17) 2002; 51 G Fiorelli (9518_CR28) 1999; 71 DJ Hunter (9518_CR58) 2007; 39 S Singh (9518_CR24) 1993; 34 A Jemal (9518_CR1) 2008; 58 JH Moore (9518_CR50) 2004; 4 TV Clendenen (9518_CR16) 2009; 18 GD Means (9518_CR29) 1989; 264 E Odagiri (9518_CR4) 1985; 56 NJ Froggatt (9518_CR2) 1999; 36 S Kono (9518_CR20) 1998; 9 AM Dunning (9518_CR63) 2009; 18 JD Potter (9518_CR7) 1983; 71 I Tomlinson (9518_CR34) 2007; 39 P Broderick (9518_CR39) 2007; 39 DG Cox (9518_CR44) 2008; 122 FR Schumacher (9518_CR59) 2007; 67 M Ochiai (9518_CR3) 1996; 17 A Zeleniuch-Jacquotte (9518_CR53) 1997; 145 Y Benjamini (9518_CR51) 2005; 171 ML Slattery (9518_CR32) 2005; 14 AJ McMichael (9518_CR11) 1985; 75 BW Zanke (9518_CR35) 2007; 39 DV Zaykin (9518_CR46) 2002; 53 CL Pearce (9518_CR43) 2005; 97 |
| References_xml | – volume: 246 start-page: 133 issue: 2 year: 1999 end-page: 138 ident: CR18 article-title: Oestrogen receptors—an overview publication-title: J Intern Med doi: 10.1046/j.1365-2796.1999.00545.x – volume: 9 start-page: 441 issue: 4 year: 1998 end-page: 446 ident: CR20 article-title: Glucose intolerance and adenomas of the sigmoid colon in Japanese men (Japan) publication-title: Cancer Causes Control doi: 10.1023/A:1008879920140 – volume: 40 start-page: 631 issue: 5 year: 2008 end-page: 637 ident: CR37 article-title: Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 publication-title: Nat Genet doi: 10.1038/ng.133 – volume: 72 start-page: 225 issue: 4 year: 1999 end-page: 229 ident: CR27 article-title: Expression of receptors for estrogen and progesterone in malignant colonic mucosa as a prognostic factor for patient survival publication-title: J Surg Oncol doi: 10.1002/(SICI)1096-9098(199912)72:4<225::AID-JSO8>3.0.CO;2-S – volume: 37 start-page: 737 issue: 6 year: 1995 end-page: 739 ident: CR9 article-title: Oestrogen and colonic epithelial cell growth publication-title: Gut doi: 10.1136/gut.37.6.737 – volume: 68 start-page: 329 issue: 1 year: 2008 end-page: 337 ident: CR15 article-title: Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-2946 – volume: 67 start-page: 947 issue: 4 year: 2000 end-page: 959 ident: CR45 article-title: Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data publication-title: Am J Hum Genet doi: 10.1086/303069 – volume: 65 start-page: 1201 issue: 6 year: 1980 end-page: 1207 ident: CR12 article-title: Reproduction, endogenous and exogenous sex hormones, and colon cancer: a review and hypothesis publication-title: J Natl Cancer Inst – volume: 138 start-page: 4030 issue: 9 year: 1997 end-page: 4033 ident: CR65 article-title: Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription publication-title: Endocrinology doi: 10.1210/en.138.9.4030 – volume: 447 start-page: 1087 issue: 7148 year: 2007 end-page: 1093 ident: CR57 article-title: Genome-wide association study identifies novel breast cancer susceptibility loci publication-title: Nature doi: 10.1038/nature05887 – volume: 122 start-page: 387 issue: 2 year: 2008 end-page: 392 ident: CR44 article-title: Haplotypes of the estrogen receptor beta gene and breast cancer risk publication-title: Int J Cancer doi: 10.1002/ijc.23127 – volume: 19 start-page: 376 issue: 3 year: 2003 end-page: 382 ident: CR49 article-title: Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions publication-title: Bioinformatics doi: 10.1093/bioinformatics/btf869 – volume: 12 start-page: 1071 issue: 4 year: 2005 end-page: 1082 ident: CR54 article-title: Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition publication-title: Endocr Relat Cancer doi: 10.1677/erc.1.01038 – volume: 171 start-page: 783 issue: 2 year: 2005 end-page: 790 ident: CR51 article-title: Quantitative trait loci analysis using the false discovery rate publication-title: Genetics doi: 10.1534/genetics.104.036699 – volume: 67 start-page: 2951 issue: 7 year: 2007 end-page: 2956 ident: CR59 article-title: A common 8q24 variant in prostate and breast cancer from a large nested case-control study publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-3591 – volume: 12 start-page: 2679 issue: 20 year: 2003 end-page: 2692 ident: CR42 article-title: A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort publication-title: Hum Mol Genet doi: 10.1093/hmg/ddg294 – volume: 21 start-page: 263 issue: 2 year: 2005 end-page: 265 ident: CR41 article-title: Haploview: analysis and visualization of LD and haplotype maps publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 – volume: 4 start-page: 795 issue: 6 year: 2004 end-page: 803 ident: CR50 article-title: Computational analysis of gene-gene interactions using multifactor dimensionality reduction publication-title: Expert Rev Mol Diagn doi: 10.1586/14737159.4.6.795 – volume: 45 start-page: 261 issue: 4 year: 2003 end-page: 266 ident: CR26 article-title: Sex steroid receptors, secondary bile acids and colorectal cancer. A possible mechanism of interaction publication-title: Panminerva Med – volume: 39 start-page: 984 issue: 8 year: 2007 end-page: 988 ident: CR34 article-title: A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 publication-title: Nat Genet doi: 10.1038/ng2085 – volume: 142 start-page: 425 issue: 6 year: 2005 end-page: 432 ident: CR40 article-title: C-reactive protein levels are not associated with increased risk for colorectal cancer in women publication-title: Ann Intern Med – volume: 40 start-page: 26 issue: 1 year: 2008 end-page: 28 ident: CR38 article-title: Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk publication-title: Nat Genet doi: 10.1038/ng.2007.41 – volume: 67 start-page: 1893 issue: 5 year: 2007 end-page: 1897 ident: CR55 article-title: Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-4123 – volume: 39 start-page: 1315 issue: 11 year: 2007 end-page: 1317 ident: CR39 article-title: A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk publication-title: Nat Genet doi: 10.1038/ng.2007.18 – volume: 291 start-page: 1701 issue: 14 year: 2004 end-page: 1712 ident: CR14 article-title: Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial publication-title: Jama doi: 10.1001/jama.291.14.1775 – volume: 34 start-page: 611 issue: 5 year: 1993 end-page: 615 ident: CR24 article-title: Sex differences in the incidence of colorectal cancer: an exploration of oestrogen and progesterone receptors publication-title: Gut doi: 10.1136/gut.34.5.611 – volume: 18 start-page: 275 issue: 1 year: 2009 end-page: 281 ident: CR16 article-title: Postmenopausal levels of endogenous sex hormones and risk of colorectal cancer publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-08-0777 – volume: 185 start-page: 577 issue: 3 year: 2005 end-page: 592 ident: CR66 article-title: Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells publication-title: J Endocrinol doi: 10.1677/joe.1.05770 – volume: 7 start-page: 536 issue: 4 year: 1994 end-page: 540 ident: CR22 article-title: Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon publication-title: Nat Genet doi: 10.1038/ng0894-536 – volume: 51 start-page: 147 issue: 2 year: 2002 ident: CR17 article-title: Obesity, gender, and colon cancer publication-title: Gut doi: 10.1136/gut.51.2.147 – ident: CR64 – volume: 87 start-page: 517 issue: 7 year: 1995 end-page: 523 ident: CR6 article-title: Estrogen replacement therapy and risk of fatal colon cancer in a prospective cohort of postmenopausal women publication-title: J Natl Cancer Inst doi: 10.1093/jnci/87.7.517 – volume: 264 start-page: 19385 issue: 32 year: 1989 end-page: 19391 ident: CR29 article-title: Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis publication-title: J Biol Chem – volume: 145 start-page: 1030 issue: 11 year: 1997 end-page: 1038 ident: CR53 article-title: Relation of serum levels of testosterone and dehydroepiandrosterone sulfate to risk of breast cancer in postmenopausal women publication-title: Am J Epidemiol – volume: 39 start-page: 989 issue: 8 year: 2007 end-page: 994 ident: CR35 article-title: Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 publication-title: Nat Genet doi: 10.1038/ng2089 – volume: 39 start-page: 865 issue: 7 year: 2007 end-page: 869 ident: CR60 article-title: Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer publication-title: Nat Genet doi: 10.1038/ng2064 – volume: 97 start-page: 51 issue: 1 year: 2005 end-page: 59 ident: CR43 article-title: Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis publication-title: J Natl Cancer Inst – volume: 71 start-page: 703 issue: 4 year: 1983 end-page: 709 ident: CR7 article-title: Large bowel cancer in women in relation to reproductive and hormonal factors: a case-control study publication-title: J Natl Cancer Inst – volume: 71 start-page: 223 issue: 5–6 year: 1999 end-page: 230 ident: CR28 article-title: Estrogen synthesis in human colon cancer epithelial cells publication-title: J Steroid Biochem Mol Biol doi: 10.1016/S0960-0760(99)00144-2 – volume: 56 start-page: 2627 issue: 11 year: 1985 end-page: 2634 ident: CR4 article-title: Steroid receptors in dimethylhydrazine-induced colon carcinogenesis publication-title: Cancer doi: 10.1002/1097-0142(19851201)56:11<2627::AID-CNCR2820561116>3.0.CO;2-J – volume: 28 start-page: 261 issue: 3 year: 2005 end-page: 272 ident: CR47 article-title: Accounting for haplotype uncertainty in matched association studies: a comparison of simple and flexible techniques publication-title: Genet Epidemiol doi: 10.1002/gepi.20061 – volume: 90 start-page: 1292 issue: 17 year: 1998 end-page: 1299 ident: CR52 article-title: Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women publication-title: J Natl Cancer Inst doi: 10.1093/jnci/90.17.1292 – volume: 53 start-page: 79 issue: 2 year: 2002 end-page: 91 ident: CR46 article-title: Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals publication-title: Hum Hered doi: 10.1159/000057986 – volume: 24 start-page: 150 issue: 2 year: 2003 end-page: 157 ident: CR48 article-title: Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity publication-title: Genet Epidemiol doi: 10.1002/gepi.10218 – volume: 58 start-page: 71 issue: 2 year: 2008 end-page: 96 ident: CR1 article-title: Cancer statistics, 2008 publication-title: CA Cancer J Clin doi: 10.3322/CA.2007.0010 – volume: 41 start-page: 324 issue: 3 year: 2009 end-page: 328 ident: CR62 article-title: Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1 publication-title: Nat Genet doi: 10.1038/ng.318 – volume: 36 start-page: 97 issue: 2 year: 1999 end-page: 102 ident: CR2 article-title: A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer publication-title: J Med Genet – volume: 129 start-page: 533 issue: 3 year: 1989 end-page: 542 ident: CR8 article-title: Children, age at first birth, and colorectal cancer risk data from the Melbourne Colorectal Cancer Study publication-title: Am J Epidemiol – volume: 61 start-page: 632 issue: 2 year: 2001 end-page: 640 ident: CR19 article-title: Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer publication-title: Cancer Res – volume: 7 start-page: 123 year: 2007 ident: CR33 article-title: Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk publication-title: BMC Cancer doi: 10.1186/1471-2407-7-123 – volume: 18 start-page: 1131 issue: 6 year: 2009 end-page: 1139 ident: CR63 article-title: Association of ESR1 gene tagging SNPs with breast cancer risk publication-title: Hum Mol Genet doi: 10.1093/hmg/ddn429 – volume: 46 start-page: 3155 issue: 30 year: 1999 end-page: 3158 ident: CR25 article-title: Estrogen and progesterone receptors in gastric and colorectal cancer publication-title: Hepatogastroenterology – volume: 17 start-page: 95 issue: 1 year: 1996 end-page: 98 ident: CR3 article-title: DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis publication-title: Carcinogenesis doi: 10.1093/carcin/17.1.95 – volume: 75 start-page: 185 issue: 2 year: 1985 end-page: 191 ident: CR11 article-title: Host factors in carcinogenesis: certain bile-acid metabolic profiles that selectively increase the risk of proximal colon cancer publication-title: J Natl Cancer Inst – volume: 40 start-page: 623 issue: 5 year: 2008 end-page: 630 ident: CR36 article-title: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 publication-title: Nat Genet doi: 10.1038/ng.111 – volume: 14 start-page: 2936 issue: 12 year: 2005 end-page: 2942 ident: CR32 article-title: Associations between ERalpha, ERbeta, and AR genotypes and colon and rectal cancer publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-05-0514 – volume: 53 start-page: 1093 issue: 4 year: 1974 end-page: 1097 ident: CR10 article-title: Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of -methyl- ′-nitro- -nitrosoguanidine in rats publication-title: J Natl Cancer Inst – volume: 288 start-page: 321 issue: 3 year: 2002 end-page: 333 ident: CR13 article-title: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial publication-title: Jama doi: 10.1001/jama.288.3.321 – volume: 41 start-page: 579 issue: 5 year: 2009 end-page: 584 ident: CR61 article-title: A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1) publication-title: Nat Genet doi: 10.1038/ng.353 – volume: 37 start-page: 1463 issue: 12 year: 2001 end-page: 1468 ident: CR31 article-title: Oestrogen and vitamin D receptor (VDR) genotypes and the expression of ErbB-2 and EGF receptor in human rectal cancers publication-title: Eur J Cancer doi: 10.1016/S0959-8049(01)00139-3 – volume: 39 start-page: 870 issue: 7 year: 2007 end-page: 874 ident: CR58 article-title: A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer publication-title: Nat Genet doi: 10.1038/ng2075 – volume: 344 start-page: 276 issue: 4 year: 2001 end-page: 285 ident: CR30 article-title: Estrogen and the risk of breast cancer publication-title: N Engl J Med doi: 10.1056/NEJM200101253440407 – volume: 14 start-page: 17 issue: 1 year: 2005 end-page: 21 ident: CR21 article-title: Loss of expression of oestrogen receptor beta in colon cancer and its association with Dukes’ staging publication-title: Oncol Rep – volume: 35 start-page: 305 issue: 4 year: 1992 end-page: 309 ident: CR23 article-title: Sex steroid hormone receptors, epidermal growth factor receptor, and polyamines in human colorectal cancer publication-title: Dis Colon Rectum doi: 10.1007/BF02048105 – volume: 81 start-page: 117 issue: 1 year: 1993 end-page: 120 ident: CR5 article-title: Action of estrogen and adrenocorticoids on adenocarcinoma induction by 1,2-dimethylhydrazine in male rats publication-title: Res Commun Chem Pathol Pharmacol – volume: 96 start-page: 936 issue: 12 year: 2004 end-page: 945 ident: CR56 article-title: Polymorphisms associated with circulating sex hormone levels in postmenopausal women publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djh167 – volume: 129 start-page: 533 issue: 3 year: 1989 ident: 9518_CR8 publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a115165 – volume: 21 start-page: 263 issue: 2 year: 2005 ident: 9518_CR41 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 – volume: 39 start-page: 865 issue: 7 year: 2007 ident: 9518_CR60 publication-title: Nat Genet doi: 10.1038/ng2064 – volume: 37 start-page: 1463 issue: 12 year: 2001 ident: 9518_CR31 publication-title: Eur J Cancer doi: 10.1016/S0959-8049(01)00139-3 – volume: 81 start-page: 117 issue: 1 year: 1993 ident: 9518_CR5 publication-title: Res Commun Chem Pathol Pharmacol – volume: 4 start-page: 795 issue: 6 year: 2004 ident: 9518_CR50 publication-title: Expert Rev Mol Diagn doi: 10.1586/14737159.4.6.795 – volume: 7 start-page: 536 issue: 4 year: 1994 ident: 9518_CR22 publication-title: Nat Genet doi: 10.1038/ng0894-536 – volume: 246 start-page: 133 issue: 2 year: 1999 ident: 9518_CR18 publication-title: J Intern Med doi: 10.1046/j.1365-2796.1999.00545.x – volume: 40 start-page: 26 issue: 1 year: 2008 ident: 9518_CR38 publication-title: Nat Genet doi: 10.1038/ng.2007.41 – volume: 12 start-page: 2679 issue: 20 year: 2003 ident: 9518_CR42 publication-title: Hum Mol Genet doi: 10.1093/hmg/ddg294 – volume: 24 start-page: 150 issue: 2 year: 2003 ident: 9518_CR48 publication-title: Genet Epidemiol doi: 10.1002/gepi.10218 – volume: 17 start-page: 95 issue: 1 year: 1996 ident: 9518_CR3 publication-title: Carcinogenesis doi: 10.1093/carcin/17.1.95 – volume: 67 start-page: 2951 issue: 7 year: 2007 ident: 9518_CR59 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-3591 – volume: 51 start-page: 147 issue: 2 year: 2002 ident: 9518_CR17 publication-title: Gut doi: 10.1136/gut.51.2.147 – volume: 34 start-page: 611 issue: 5 year: 1993 ident: 9518_CR24 publication-title: Gut doi: 10.1136/gut.34.5.611 – volume: 18 start-page: 275 issue: 1 year: 2009 ident: 9518_CR16 publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-08-0777 – volume: 39 start-page: 989 issue: 8 year: 2007 ident: 9518_CR35 publication-title: Nat Genet doi: 10.1038/ng2089 – volume: 96 start-page: 936 issue: 12 year: 2004 ident: 9518_CR56 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djh167 – volume: 18 start-page: 1131 issue: 6 year: 2009 ident: 9518_CR63 publication-title: Hum Mol Genet doi: 10.1093/hmg/ddn429 – volume: 171 start-page: 783 issue: 2 year: 2005 ident: 9518_CR51 publication-title: Genetics doi: 10.1534/genetics.104.036699 – volume: 19 start-page: 376 issue: 3 year: 2003 ident: 9518_CR49 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btf869 – volume: 185 start-page: 577 issue: 3 year: 2005 ident: 9518_CR66 publication-title: J Endocrinol doi: 10.1677/joe.1.05770 – volume: 40 start-page: 623 issue: 5 year: 2008 ident: 9518_CR36 publication-title: Nat Genet doi: 10.1038/ng.111 – volume: 39 start-page: 1315 issue: 11 year: 2007 ident: 9518_CR39 publication-title: Nat Genet doi: 10.1038/ng.2007.18 – volume: 56 start-page: 2627 issue: 11 year: 1985 ident: 9518_CR4 publication-title: Cancer doi: 10.1002/1097-0142(19851201)56:11<2627::AID-CNCR2820561116>3.0.CO;2-J – volume: 35 start-page: 305 issue: 4 year: 1992 ident: 9518_CR23 publication-title: Dis Colon Rectum doi: 10.1007/BF02048105 – volume: 14 start-page: 2936 issue: 12 year: 2005 ident: 9518_CR32 publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-05-0514 – volume: 122 start-page: 387 issue: 2 year: 2008 ident: 9518_CR44 publication-title: Int J Cancer doi: 10.1002/ijc.23127 – volume: 39 start-page: 870 issue: 7 year: 2007 ident: 9518_CR58 publication-title: Nat Genet doi: 10.1038/ng2075 – volume: 264 start-page: 19385 issue: 32 year: 1989 ident: 9518_CR29 publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)47313-4 – volume: 36 start-page: 97 issue: 2 year: 1999 ident: 9518_CR2 publication-title: J Med Genet – volume: 291 start-page: 1701 issue: 14 year: 2004 ident: 9518_CR14 publication-title: Jama doi: 10.1001/jama.291.14.1775 – volume: 28 start-page: 261 issue: 3 year: 2005 ident: 9518_CR47 publication-title: Genet Epidemiol doi: 10.1002/gepi.20061 – volume: 142 start-page: 425 issue: 6 year: 2005 ident: 9518_CR40 publication-title: Ann Intern Med doi: 10.7326/0003-4819-142-6-200503150-00008 – volume: 67 start-page: 1893 issue: 5 year: 2007 ident: 9518_CR55 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-4123 – volume: 288 start-page: 321 issue: 3 year: 2002 ident: 9518_CR13 publication-title: Jama doi: 10.1001/jama.288.3.321 – volume: 9 start-page: 441 issue: 4 year: 1998 ident: 9518_CR20 publication-title: Cancer Causes Control doi: 10.1023/A:1008879920140 – volume: 97 start-page: 51 issue: 1 year: 2005 ident: 9518_CR43 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/dji007 – volume: 12 start-page: 1071 issue: 4 year: 2005 ident: 9518_CR54 publication-title: Endocr Relat Cancer doi: 10.1677/erc.1.01038 – volume: 71 start-page: 223 issue: 5–6 year: 1999 ident: 9518_CR28 publication-title: J Steroid Biochem Mol Biol doi: 10.1016/S0960-0760(99)00144-2 – volume: 344 start-page: 276 issue: 4 year: 2001 ident: 9518_CR30 publication-title: N Engl J Med doi: 10.1056/NEJM200101253440407 – volume: 87 start-page: 517 issue: 7 year: 1995 ident: 9518_CR6 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/87.7.517 – volume: 53 start-page: 79 issue: 2 year: 2002 ident: 9518_CR46 publication-title: Hum Hered doi: 10.1159/000057986 – volume: 41 start-page: 579 issue: 5 year: 2009 ident: 9518_CR61 publication-title: Nat Genet doi: 10.1038/ng.353 – volume: 67 start-page: 947 issue: 4 year: 2000 ident: 9518_CR45 publication-title: Am J Hum Genet doi: 10.1086/303069 – volume: 145 start-page: 1030 issue: 11 year: 1997 ident: 9518_CR53 publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a009059 – volume: 447 start-page: 1087 issue: 7148 year: 2007 ident: 9518_CR57 publication-title: Nature doi: 10.1038/nature05887 – volume: 61 start-page: 632 issue: 2 year: 2001 ident: 9518_CR19 publication-title: Cancer Res – volume: 46 start-page: 3155 issue: 30 year: 1999 ident: 9518_CR25 publication-title: Hepatogastroenterology – volume: 90 start-page: 1292 issue: 17 year: 1998 ident: 9518_CR52 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/90.17.1292 – volume: 41 start-page: 324 issue: 3 year: 2009 ident: 9518_CR62 publication-title: Nat Genet doi: 10.1038/ng.318 – volume: 53 start-page: 1093 issue: 4 year: 1974 ident: 9518_CR10 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/53.4.1093 – volume: 45 start-page: 261 issue: 4 year: 2003 ident: 9518_CR26 publication-title: Panminerva Med – volume: 37 start-page: 737 issue: 6 year: 1995 ident: 9518_CR9 publication-title: Gut doi: 10.1136/gut.37.6.737 – volume: 65 start-page: 1201 issue: 6 year: 1980 ident: 9518_CR12 publication-title: J Natl Cancer Inst – volume: 39 start-page: 984 issue: 8 year: 2007 ident: 9518_CR34 publication-title: Nat Genet doi: 10.1038/ng2085 – volume: 75 start-page: 185 issue: 2 year: 1985 ident: 9518_CR11 publication-title: J Natl Cancer Inst – volume: 40 start-page: 631 issue: 5 year: 2008 ident: 9518_CR37 publication-title: Nat Genet doi: 10.1038/ng.133 – ident: 9518_CR64 doi: 10.1093/carcin/bgp273 – volume: 138 start-page: 4030 issue: 9 year: 1997 ident: 9518_CR65 publication-title: Endocrinology doi: 10.1210/endo.138.9.5489 – volume: 68 start-page: 329 issue: 1 year: 2008 ident: 9518_CR15 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-2946 – volume: 7 start-page: 123 year: 2007 ident: 9518_CR33 publication-title: BMC Cancer doi: 10.1186/1471-2407-7-123 – volume: 72 start-page: 225 issue: 4 year: 1999 ident: 9518_CR27 publication-title: J Surg Oncol doi: 10.1002/(SICI)1096-9098(199912)72:4<225::AID-JSO8>3.0.CO;2-S – volume: 71 start-page: 703 issue: 4 year: 1983 ident: 9518_CR7 publication-title: J Natl Cancer Inst – volume: 58 start-page: 71 issue: 2 year: 2008 ident: 9518_CR1 publication-title: CA Cancer J Clin doi: 10.3322/CA.2007.0010 – volume: 14 start-page: 17 issue: 1 year: 2005 ident: 9518_CR21 publication-title: Oncol Rep |
| SSID | ssj0005620 |
| Score | 2.0352266 |
| Snippet | Objectives Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which... Objectives Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which... Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex... Objectives: Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which... |
| SourceID | pubmedcentral proquest pubmed crossref springer jstor fao |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 897 |
| SubjectTerms | Aged Ambulatory care Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Cardiovascular disease Colorectal cancer colorectal neoplasms Colorectal Neoplasms - genetics CYP19A1 Cytochrome Dehydrogenases Disease prevention Endocrine therapy Enzymes Epidemiology Estradiol Dehydrogenases Estradiol Dehydrogenases - genetics Estrogen receptors Estrogens Ethnicity Ethnicity - genetics Female Females Genes Genetic loci Genetic Variation Genetic Variation - genetics genetics Gonadal Steroid Hormones Gonadal Steroid Hormones - genetics Haplotypes Health care Hematology Hormones Hospitals HSD17B2 Humans Logistic Models Middle Aged Odds Ratio Oncology Original Paper Polymorphism, Single Nucleotide Postmenopause Preventive medicine Progesterone receptor Public Health Receptors Receptors, Estrogen Receptors, Estrogen - genetics Receptors, Progesterone Receptors, Progesterone - genetics Receptors, Steroid Receptors, Steroid - genetics Risk Factors Sex hormone genes Sex hormones Steroids Tumors White People White People - genetics Womens health |
| SummonAdditionalLinks | – databaseName: SpringerLink Contemporary (1997 - Present) dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxQxDLZoQQgJ8Si0HQooB06gSPNIMpMjQlQcoEKUot6iTCZpR4LZamdbtf312PNaFspKcNhTPNnEcRw7tr8AvLKl0iJXgrtEey6qEHgRnMKNl8U6Vc6W_Up_zA8OiuNj_Xmo427HbPcxJNlp6l-K3aSkNIKYo1VQcLkBt_G0K-i9hi-H35Z5HarHYtQyRy9LZGMo86YuVg6jjWBnY1biTfbmn2mTv8VOuyNp_-F_TeYRPBgsUPa2F5nHcMs3W3D30xBj34L7_U0e6wuUnsAJIVMjLbtAt7pbR1Y3rPWXnDAWZnXFUGn6M3q1h9mmYu1Vg0ZlW1_jeJhvrq9--L6B8LFJv-KfO5K1OaO8duqsg4F4Ckf777---8CH5xm4w22-4EkoXeoIYNAFlTuXZigQWvtY2SxDT6dMggzBh0QXPsuUqlwpKpIZWcaB6nm3YbOZNX4XWIidrLT0Aq0z9E_RBLEqoC9nfVAOfxHE4zoZN2CX0xMa380SdZkYapChhhhqZASvp0_OeuCOdcS7uPjGnuC8zdFhSuFcdH1RO-URbHcSMXUiCOFPFTimvVFEzLDvW5Pih6ixhYiATa24YSkKYxs_O29NTlVuqEWTNSSCqgTRuFhHIhVyudAR7PRSOQ0wpUviTMUR5CvyOhEQovhqS1OfdsjiyPIMXeYI3oxSu5zaX5n37J-o9-Ben4BBF1nPYXMxP_cv4I67WNTt_GW3lX8C0uVCaw priority: 102 providerName: Springer Nature |
| Title | Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women |
| URI | https://www.jstor.org/stable/40645686 https://link.springer.com/article/10.1007/s10552-010-9518-5 https://www.ncbi.nlm.nih.gov/pubmed/20148360 https://www.proquest.com/docview/213076344 https://www.proquest.com/docview/733522251 https://www.proquest.com/docview/742702303 https://www.proquest.com/docview/745633289 https://pubmed.ncbi.nlm.nih.gov/PMC2873149 |
| Volume | 21 |
| WOSCitedRecordID | wos000277709800012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1573-7225 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0005620 issn: 0957-5243 databaseCode: 7X7 dateStart: 19990101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1573-7225 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0005620 issn: 0957-5243 databaseCode: 7RV dateStart: 19990101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1573-7225 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0005620 issn: 0957-5243 databaseCode: BENPR dateStart: 19990101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1573-7225 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0005620 issn: 0957-5243 databaseCode: 8C1 dateStart: 19990101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1573-7225 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005620 issn: 0957-5243 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED-xDSEkxMdgWxhMfuAJFJEvO_ETgmkTD1BNHZv6ZiWOvVWCpGu6ie2v5y5OUpWPvvBQS5Wvqe07X-58dz8DvMkLIZNUJL4OpfGT0lo_s1rgxosDGQmdF47TX9LRKJtM5EmXm9N0aZW9TmwVdVlrOiN_H6Gyxb2QJB9mVz5dGkXB1e4GjQ3YCsk0RnFOx-fLDA_hUBklT9HfSuI-qOkq5zinnITARxMj8_nKa2nD5nWfn_g3y_PPBMrfoqjty-n4yX9O6yk87qxS9tGJ0TO4Z6ptePC1i7tvwyN3usdc0dJzuCC0aqRlN-hqt7xl04o15qdPuAv1tGSoSM2MbvJheVWy5rZCQ7OZ3uHomanubn8Y10GY2aRz8c81yd-cUa47PayFhngBZ8dH3w4_-92VDb7Grb_wQ1voSBPooLYi1TqKUUikNIHI4xi9nyK03FpjQ5mZOBai1EVSkhzxIrBU47sDm1VdmT1gNtC8lNwkaLGhz4pmSS4s-ne5sULjx4Og55jSHZ45XavxXS2RmInJCpmsiMmKe_B2-MnMgXmsI95DMVD5Bc5bnZ1GFOJFdxg1VurBTisbw0MSQv0TGY5pv-ey6nRBowYWe8CGXtzEFJnJK1NfNyqlyjfUrOEakoQqB9HgWEfCBa5yJj3YdfI5DDCig-NYBB6kK5I7EBDK-GpPNb1s0cZxyWN0oz1418v4cmr_XLyXaxdiHx66JAw6zHoFm4v5tXkN9_XNYtrMD9pNTO0kbdsM2-wwPICtT0ejkzF-G5-e_wJNQVHF |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB61BQES4lEoDeXhA1xAEdnEcZIDQgioWnW7QqKV9uYmjl0iQbJstoXtf-I_MhMnWS2PvfXAYU92vPHkm_GMPfMZ4FmaiYRHgrtqkGiX58a4sVECFS_wEl-oNLNfehiNRvF4nHxcg59dLQylVXY2sTHUeaVoj_yVj8YWdYHzN5NvLl0aRYer3Q0aFhUHev4dI7b69f57_LzPfX_3w9G7Pbe9VMBVCM6ZOzCZ8hXR4ikjIqX8AKeRJNoTaRCgf54NTGiMNhiM6yAQIlcZz2mmYeYZqkLFcdfhCprxiGK9aBwtMkqEZYFMwgjjOx50h6i2Ui8MKQfCc9Glid1waRlcN2nV5UP-zdP9M2Hzt1PbZjHcvf2fifEO3Gq9bvbWqsldWNPlJlw7bPMKNuGm3b1ktijrHpwSGzf2Zefp1GKXFSWr9Q-XeCWqIme4UOgJ3VTE0jJn9bxER7ouLlBaTJcX86_aNhAnOK0p-OeK9GvKKJefBmuoL-7D8aVMews2yqrU28CMp8I8CTVHjxRjcnS7UmEwfk21EQp_DngdQqRq-drp2pAvcsE0TaCSCCpJoJKhAy_6RyaWrGRV522EnUxPcd7y-JNPR9gY7qNFjhzYarDYD8KJ1VDE-E47Hapka-tq2UPKAda3opGik6e01NVZLSOq7MOVY7CiC6fKSHSoVnUJBUo5Thx4YPWhf0GfNsYD4TkQLWlK34FY1JdbyuJzw6aOIg8GHMd82enUYmr_FN7DlYJ4Ctf3jg6Hcrg_OtiBGzbhhDbuHsHGbHqmH8NVdT4r6umTxoAwOLlsVfsFPjGsaw |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB61BVVIiEdpaSgPH-ACiprEjpMcEEItK6qWqhJU6s0kjl1Wguyy2Ra2_4x_x0ycpCyPvfXAYU92vPHkm_GMPfMZ4GleyEwkUvg6zIwvSmv91GqJiseDLJI6L9yXPkgOD9OTk-xoCX50tTCUVtnZxMZQlyNNe-TbERpb1AUhtm2bFXG0O3g1_urTBVJ00NrdpuEQsm9m3zB6q1_u7eKnfhZFgzcfdt767QUDvkagTv3QFjrSRJGnrUy0jjhOKctMIHPO0VcvQhtbaywG5oZzKUtdiJJmHReBpYpUHHcZriVccor70p1fskukY4TM4gRjPcG7A1VXtRfHlA8R-OjepH48tyQu23zU5Ub-zev9M3nztxPcZmEc3P6PRXoHbrXeOHvt1OcuLJlqDVbftfkGa3DT7WoyV6x1D06JpRv7svN84jDNhhWrzXef-CZGw5LhAmLGdIMRy6uS1bMKHex6eIGSY6a6mH0xroG4wmmtwT_XpHcTRjn-NFhDibEOx1cy7Q1YqUaV2QRmAx2XWWwEeqoYq6M7lkuLcW1urNT48yDo0KJ0y-NO14l8VpcM1AQwhQBTBDAVe_C8f2TsSEwWdd5ECKr8FOetjt9HdLQdpgItdeLBRoPLfhBBbIcyxXfa6hCmWhtYqx5eHrC-FY0XnUjllRmd1Sqhij9cUcIFXQRVTKKjtahLLFHKaebBfacb_QtGtGHOZeBBMqc1fQdiV59vqYafGpZ1FDkPBY75otOvy6n9U3gPFgriCayihqmDvcP9Lbjh8lBoP-8hrEwnZ-YRXNfn02E9edzYEgYfr1rTfgLIorTy |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+variation+in+sex-steroid+receptors+and+synthesizing+enzymes+and+colorectal+cancer+risk+in+women&rft.jtitle=Cancer+causes+%26+control&rft.au=Lin%2C+Jennifer&rft.au=Zee%2C+Robert+Y+L&rft.au=Liu%2C+Kuang-Yu&rft.au=Zhang%2C+Shumin+M&rft.date=2010-06-01&rft.eissn=1573-7225&rft.volume=21&rft.issue=6&rft.spage=897&rft_id=info:doi/10.1007%2Fs10552-010-9518-5&rft_id=info%3Apmid%2F20148360&rft.externalDocID=20148360 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0957-5243&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0957-5243&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0957-5243&client=summon |