Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers
Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance. We measured insulin sensitivity by glucose tolerance test and vascular function by ultrasound and venous occlusion plethysmograp...
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| Vydané v: | Arteriosclerosis, thrombosis, and vascular biology Ročník 27; číslo 12; s. 2650 |
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| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
01.12.2007
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| Predmet: | |
| ISSN: | 1524-4636, 1524-4636 |
| On-line prístup: | Zistit podrobnosti o prístupe |
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| Abstract | Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance.
We measured insulin sensitivity by glucose tolerance test and vascular function by ultrasound and venous occlusion plethysmography in 20 healthy subjects (14 men, 6 women) at baseline and during 5 days of bed rest. Bed rest led to a 67% increase in the insulin response to glucose loading (P<0.001) suggesting increased insulin resistance and produced increases in total cholesterol and triglycerides. Bed rest led to decreased reactive hyperemia in the forearm (1317+/-404 to 1112+/-260 mL/min, P=0.01) and the calf (28.5+/-7.0 to 22.2+/-8.7 mL/min/dL, P=0.003) indicating impaired microvascular function. Bed rest decreased brachial artery diameter and increased systolic blood pressure suggesting increased basal arterial tone. There were no changes in circulating inflammatory markers arguing against systemic inflammation as a mechanism for vascular dysfunction in this setting.
Physical inactivity was associated with the development of insulin resistance, dyslipidemia, increased blood pressure, and impaired microvascular function in healthy volunteers. Our findings may provide insight into the pathogenesis of vascular disease in sedentary individuals and emphasize that even short-term physical inactivity may have adverse metabolic and vascular consequences. |
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| AbstractList | Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance.OBJECTIVESedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance.We measured insulin sensitivity by glucose tolerance test and vascular function by ultrasound and venous occlusion plethysmography in 20 healthy subjects (14 men, 6 women) at baseline and during 5 days of bed rest. Bed rest led to a 67% increase in the insulin response to glucose loading (P<0.001) suggesting increased insulin resistance and produced increases in total cholesterol and triglycerides. Bed rest led to decreased reactive hyperemia in the forearm (1317+/-404 to 1112+/-260 mL/min, P=0.01) and the calf (28.5+/-7.0 to 22.2+/-8.7 mL/min/dL, P=0.003) indicating impaired microvascular function. Bed rest decreased brachial artery diameter and increased systolic blood pressure suggesting increased basal arterial tone. There were no changes in circulating inflammatory markers arguing against systemic inflammation as a mechanism for vascular dysfunction in this setting.METHODS AND RESULTSWe measured insulin sensitivity by glucose tolerance test and vascular function by ultrasound and venous occlusion plethysmography in 20 healthy subjects (14 men, 6 women) at baseline and during 5 days of bed rest. Bed rest led to a 67% increase in the insulin response to glucose loading (P<0.001) suggesting increased insulin resistance and produced increases in total cholesterol and triglycerides. Bed rest led to decreased reactive hyperemia in the forearm (1317+/-404 to 1112+/-260 mL/min, P=0.01) and the calf (28.5+/-7.0 to 22.2+/-8.7 mL/min/dL, P=0.003) indicating impaired microvascular function. Bed rest decreased brachial artery diameter and increased systolic blood pressure suggesting increased basal arterial tone. There were no changes in circulating inflammatory markers arguing against systemic inflammation as a mechanism for vascular dysfunction in this setting.Physical inactivity was associated with the development of insulin resistance, dyslipidemia, increased blood pressure, and impaired microvascular function in healthy volunteers. Our findings may provide insight into the pathogenesis of vascular disease in sedentary individuals and emphasize that even short-term physical inactivity may have adverse metabolic and vascular consequences.CONCLUSIONSPhysical inactivity was associated with the development of insulin resistance, dyslipidemia, increased blood pressure, and impaired microvascular function in healthy volunteers. Our findings may provide insight into the pathogenesis of vascular disease in sedentary individuals and emphasize that even short-term physical inactivity may have adverse metabolic and vascular consequences. Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance. We measured insulin sensitivity by glucose tolerance test and vascular function by ultrasound and venous occlusion plethysmography in 20 healthy subjects (14 men, 6 women) at baseline and during 5 days of bed rest. Bed rest led to a 67% increase in the insulin response to glucose loading (P<0.001) suggesting increased insulin resistance and produced increases in total cholesterol and triglycerides. Bed rest led to decreased reactive hyperemia in the forearm (1317+/-404 to 1112+/-260 mL/min, P=0.01) and the calf (28.5+/-7.0 to 22.2+/-8.7 mL/min/dL, P=0.003) indicating impaired microvascular function. Bed rest decreased brachial artery diameter and increased systolic blood pressure suggesting increased basal arterial tone. There were no changes in circulating inflammatory markers arguing against systemic inflammation as a mechanism for vascular dysfunction in this setting. Physical inactivity was associated with the development of insulin resistance, dyslipidemia, increased blood pressure, and impaired microvascular function in healthy volunteers. Our findings may provide insight into the pathogenesis of vascular disease in sedentary individuals and emphasize that even short-term physical inactivity may have adverse metabolic and vascular consequences. |
| Author | Keaney, Jr, John F McMackin, Craig J Schulz, Eberhard Gokce, Noyan Widlansky, Michael E Huang, Alex L Shenouda, Sherene M Vita, Joseph A Hamburg, Naomi M Ruderman, Neil B |
| Author_xml | – sequence: 1 givenname: Naomi M surname: Hamburg fullname: Hamburg, Naomi M organization: Section of Cardiology, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA – sequence: 2 givenname: Craig J surname: McMackin fullname: McMackin, Craig J – sequence: 3 givenname: Alex L surname: Huang fullname: Huang, Alex L – sequence: 4 givenname: Sherene M surname: Shenouda fullname: Shenouda, Sherene M – sequence: 5 givenname: Michael E surname: Widlansky fullname: Widlansky, Michael E – sequence: 6 givenname: Eberhard surname: Schulz fullname: Schulz, Eberhard – sequence: 7 givenname: Noyan surname: Gokce fullname: Gokce, Noyan – sequence: 8 givenname: Neil B surname: Ruderman fullname: Ruderman, Neil B – sequence: 9 givenname: John F surname: Keaney, Jr fullname: Keaney, Jr, John F – sequence: 10 givenname: Joseph A surname: Vita fullname: Vita, Joseph A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17932315$$D View this record in MEDLINE/PubMed |
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| PublicationTitle | Arteriosclerosis, thrombosis, and vascular biology |
| PublicationTitleAlternate | Arterioscler Thromb Vasc Biol |
| PublicationYear | 2007 |
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| Snippet | Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin... |
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| SubjectTerms | Adult Bed Rest - adverse effects Blood Glucose - metabolism Blood Pressure Brachial Artery - physiopathology Case-Control Studies Cholesterol - blood Dyslipidemias - blood Dyslipidemias - diagnostic imaging Dyslipidemias - etiology Dyslipidemias - physiopathology Female Forearm - blood supply Glucose Tolerance Test Humans Hyperemia - blood Hyperemia - diagnostic imaging Hyperemia - physiopathology Hypertension - blood Hypertension - diagnostic imaging Hypertension - etiology Hypertension - physiopathology Inflammation Mediators - blood Insulin - blood Insulin Resistance Laser-Doppler Flowmetry Leg - blood supply Male Microcirculation - physiopathology Motor Activity Reference Values Time Factors Triglycerides - blood Ultrasonography Vasodilation |
| Title | Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers |
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