Muscle Injury Induces Postoperative Cognitive Dysfunction

Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide va...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Scientific reports Ročník 10; číslo 1; s. 2768
Hlavní autoři: Guéniot, Lorna, Lepere, Victoria, De Medeiros, Gabriela Ferreira, Danckaert, Anne, Flamant, Patricia, Le Dudal, Marine, Langeron, Olivier, Goossens, Pierre L., Chrétien, Fabrice, Jouvion, Grégory
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 17.02.2020
Nature Publishing Group
Témata:
14/19
631/378/371
64/110
692/617/375
96/63
Aging - pathology
Animal cognition
Animal models
Animals
Behavioral plasticity
Brain - pathology
Brain - surgery
Brain research
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Cognitive ability
Cognitive science
Critical care
CX3C Chemokine Receptor 1 - genetics
Cytokines - metabolism
Disease Models, Animal
Experiments
Hippocampus - injuries
Hippocampus - pathology
Hippocampus - surgery
Human health and pathology
Humanities and Social Sciences
Humans
Inflammation
Life Sciences
Locomotion
Long term memory
Male
Memory
Mice
Microglia
Microglia - pathology
Morphology
multidisciplinary
Muscle, Skeletal - injuries
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Muscle, Skeletal - surgery
Nerve growth factor
Nerve Growth Factor - metabolism
Pathophysiology
Postoperative Cognitive Complications - etiology
Postoperative Cognitive Complications - metabolism
Postoperative Cognitive Complications - pathology
Postoperative Complications - etiology
Postoperative Complications - metabolism
Postoperative Complications - pathology
Regeneration
Science
Science (multidisciplinary)
Skeletal muscle
Surgery
Synaptic plasticity
Young adults
ISSN:2045-2322, 2045-2322
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide variety of rodent models, such as the murine tibial fracture, whose severity can limit mouse locomotion and proper behavioral assessment. Besides, influence of skeletal muscle injury, a lesion encountered in a wide range of surgeries, has not been explored in POCD occurrence. We propose a physical model of muscle injury in CX3CR1 GFP/+ mice (displaying green fluorescent microglial cells) to study POCD, with morphological, behavioral and molecular approaches. We highlighted: alteration of short- and long-term memory after muscle regeneration, wide microglial reactivity in the brain, including hippocampus area, 24 hours after muscle injury, and an alteration of central brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) balance, 28 days after muscle injury. Our results suggest for the first time that muscle injury can have early as well as late impacts on the brain. Our CX3CR1 GFP/+ model can also facilitate microglial investigation, more specifically their pivotal role in neuroinflammation and synaptic plasticity, in the pathophysiology of POCD.
AbstractList Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide variety of rodent models, such as the murine tibial fracture, whose severity can limit mouse locomotion and proper behavioral assessment. Besides, influence of skeletal muscle injury, a lesion encountered in a wide range of surgeries, has not been explored in POCD occurrence. We propose a physical model of muscle injury in CX3CR1 GFP/+ mice (displaying green fluorescent microglial cells) to study POCD, with morphological, behavioral and molecular approaches. We highlighted: alteration of short- and long-term memory after muscle regeneration, wide microglial reactivity in the brain, including hippocampus area, 24 hours after muscle injury, and an alteration of central brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) balance, 28 days after muscle injury. Our results suggest for the first time that muscle injury can have early as well as late impacts on the brain. Our CX3CR1 GFP/+ model can also facilitate microglial investigation, more specifically their pivotal role in neuroinflammation and synaptic plasticity, in the pathophysiology of POCD.
Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide variety of rodent models, such as the murine tibial fracture, whose severity can limit mouse locomotion and proper behavioral assessment. Besides, influence of skeletal muscle injury, a lesion encountered in a wide range of surgeries, has not been explored in POCD occurrence. We propose a physical model of muscle injury in CX3CR1GFP/+ mice (displaying green fluorescent microglial cells) to study POCD, with morphological, behavioral and molecular approaches. We highlighted: alteration of short- and long-term memory after muscle regeneration, wide microglial reactivity in the brain, including hippocampus area, 24 hours after muscle injury, and an alteration of central brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) balance, 28 days after muscle injury. Our results suggest for the first time that muscle injury can have early as well as late impacts on the brain. Our CX3CR1GFP/+ model can also facilitate microglial investigation, more specifically their pivotal role in neuroinflammation and synaptic plasticity, in the pathophysiology of POCD.
Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide variety of rodent models, such as the murine tibial fracture, whose severity can limit mouse locomotion and proper behavioral assessment. Besides, influence of skeletal muscle injury, a lesion encountered in a wide range of surgeries, has not been explored in POCD occurrence. We propose a physical model of muscle injury in CX3CR1 mice (displaying green fluorescent microglial cells) to study POCD, with morphological, behavioral and molecular approaches. We highlighted: alteration of short- and long-term memory after muscle regeneration, wide microglial reactivity in the brain, including hippocampus area, 24 hours after muscle injury, and an alteration of central brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) balance, 28 days after muscle injury. Our results suggest for the first time that muscle injury can have early as well as late impacts on the brain. Our CX3CR1 model can also facilitate microglial investigation, more specifically their pivotal role in neuroinflammation and synaptic plasticity, in the pathophysiology of POCD.
Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide variety of rodent models, such as the murine tibial fracture, whose severity can limit mouse locomotion and proper behavioral assessment. Besides, influence of skeletal muscle injury, a lesion encountered in a wide range of surgeries, has not been explored in POCD occurrence. We propose a physical model of muscle injury in CX3CR1GFP/+ mice (displaying green fluorescent microglial cells) to study POCD, with morphological, behavioral and molecular approaches. We highlighted: alteration of short- and long-term memory after muscle regeneration, wide microglial reactivity in the brain, including hippocampus area, 24 hours after muscle injury, and an alteration of central brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) balance, 28 days after muscle injury. Our results suggest for the first time that muscle injury can have early as well as late impacts on the brain. Our CX3CR1GFP/+ model can also facilitate microglial investigation, more specifically their pivotal role in neuroinflammation and synaptic plasticity, in the pathophysiology of POCD.Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide variety of rodent models, such as the murine tibial fracture, whose severity can limit mouse locomotion and proper behavioral assessment. Besides, influence of skeletal muscle injury, a lesion encountered in a wide range of surgeries, has not been explored in POCD occurrence. We propose a physical model of muscle injury in CX3CR1GFP/+ mice (displaying green fluorescent microglial cells) to study POCD, with morphological, behavioral and molecular approaches. We highlighted: alteration of short- and long-term memory after muscle regeneration, wide microglial reactivity in the brain, including hippocampus area, 24 hours after muscle injury, and an alteration of central brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) balance, 28 days after muscle injury. Our results suggest for the first time that muscle injury can have early as well as late impacts on the brain. Our CX3CR1GFP/+ model can also facilitate microglial investigation, more specifically their pivotal role in neuroinflammation and synaptic plasticity, in the pathophysiology of POCD.
ArticleNumber 2768
Author Flamant, Patricia
Lepere, Victoria
Jouvion, Grégory
Langeron, Olivier
Le Dudal, Marine
De Medeiros, Gabriela Ferreira
Chrétien, Fabrice
Goossens, Pierre L.
Danckaert, Anne
Guéniot, Lorna
Author_xml – sequence: 1
  givenname: Lorna
  surname: Guéniot
  fullname: Guéniot, Lorna
  organization: Institut Pasteur, Experimental Neuropathology Unit, Direction Générale de l’Armement, Ministère des Armées, Paris Descartes University, ED Bio-SPC, Sorbonne Paris Cité
– sequence: 2
  givenname: Victoria
  surname: Lepere
  fullname: Lepere, Victoria
  organization: Institut Pasteur, Experimental Neuropathology Unit, Multidisciplinary Intensive Care Unit, Department of Anesthesiology and Critical Care, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Polyvalent Surgical Resuscitation, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University
– sequence: 3
  givenname: Gabriela Ferreira
  surname: De Medeiros
  fullname: De Medeiros, Gabriela Ferreira
  organization: Institut Pasteur, Experimental Neuropathology Unit
– sequence: 4
  givenname: Anne
  orcidid: 0000-0001-8984-643X
  surname: Danckaert
  fullname: Danckaert, Anne
  organization: Institut Pasteur, UtechS Photonic BioImaging (Imagopole)
– sequence: 5
  givenname: Patricia
  surname: Flamant
  fullname: Flamant, Patricia
  organization: Institut Pasteur, Experimental Neuropathology Unit
– sequence: 6
  givenname: Marine
  surname: Le Dudal
  fullname: Le Dudal, Marine
  organization: Institut Pasteur, Experimental Neuropathology Unit
– sequence: 7
  givenname: Olivier
  surname: Langeron
  fullname: Langeron, Olivier
  organization: Institut Pasteur, Experimental Neuropathology Unit, Department of Anesthesia and Critical Care, Hôpitaux Universitaires Henri Mondor-Créteil-Assistance Publique Hôpitaux de Paris, Paris-Est Créteil University
– sequence: 8
  givenname: Pierre L.
  surname: Goossens
  fullname: Goossens, Pierre L.
  organization: Institut Pasteur, Experimental Neuropathology Unit
– sequence: 9
  givenname: Fabrice
  surname: Chrétien
  fullname: Chrétien, Fabrice
  organization: Institut Pasteur, Experimental Neuropathology Unit, Paris Descartes University, ED Bio-SPC, Sorbonne Paris Cité, Service de Neuropathologie, Centre Hospitalier Sainte Anne, GHU Paris Psychiatrie Neuroscience
– sequence: 10
  givenname: Grégory
  orcidid: 0000-0003-0188-2554
  surname: Jouvion
  fullname: Jouvion, Grégory
  email: gregory.jouvion@pasteur.fr
  organization: Institut Pasteur, Experimental Neuropathology Unit, Sorbonne Université, INSERM, Pathophysiology of pediatric genetic diseases, Assistance Publique-Hôpitaux de Paris, Hôpital Armand-Trousseau, UF Génétique moléculaire
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32066806$$D View this record in MEDLINE/PubMed
https://inserm.hal.science/inserm-02503658$$DView record in HAL
BookMark eNp9kU1vEzEQhi1UREvpH-CAInHpgYVZf-8FqQofrRQEBzhbjnc2dbSxg70bKf8ep9tCyaG-jCU_7-t3Zl6SkxADEvK6hvc1MP0h81o0ugIKlWgkayr2jJxR4KKijNKTR_dTcpHzGsoRtOF184KcMgpSapBnpPk2Ztfj7Casx7QvpR0d5tmPmIe4xWQHv8PZPK6Cv7t92uduDG7wMbwizzvbZ7y4r-fk15fPP-fX1eL715v51aJyQqmh6kpK0WqLndKaC1rTjslGW85t2zrKl7pWiCCXyinGABx2tGXQKIfcagR2Tj5OvttxucHWYRiS7c02-Y1NexOtN_-_BH9rVnFnFFBZZlQM3k0Gt0ey66uF8SFj2higApgUelcX_PL-vxR_j5gHs_HZYd_bgHHMhjKhuASQvKBvj9B1HFMo0zhQUgrVACvUm8cN_I3wsIQC6AlwKeacsDPOD_Yw49KP700N5rByM628ZAVzt3Jz8KZH0gf3J0VsEuUChxWmf7GfUP0BIdK9Ag
CitedBy_id crossref_primary_10_1007_s12035_023_03729_6
crossref_primary_10_3892_etm_2022_11405
crossref_primary_10_3389_fneur_2021_591223
crossref_primary_10_1080_21655979_2021_1967838
crossref_primary_10_3389_fphys_2024_1464326
crossref_primary_10_1213_ANE_0000000000005681
Cites_doi 10.1523/JNEUROSCI.3667-11.2011
10.1016/j.neubiorev.2017.11.011
10.1093/bja/aex103
10.1093/bja/82.6.867
10.1038/srep03766
10.1038/nm.4397
10.1523/JNEUROSCI.4040-14.2015
10.1073/pnas.1014557107
10.1016/0896-6273(92)90213-W
10.3390/ijms18040769
10.1016/j.cell.2013.11.030
10.1523/JNEUROSCI.20-16-06309.2000
10.1038/npp.2016.185
10.1523/JNEUROSCI.0910-11.2011
10.1038/nmeth.2019
10.1523/JNEUROSCI.21-08-02580.2001
10.1213/ANE.0000000000003514
10.1177/0300060517754032
10.1038/nprot.2013.155
10.1016/j.neubiorev.2004.06.006
10.1016/0166-4328(94)90008-6
10.1111/anae.14606
10.1096/fj.14-270090
10.1007/BF03021625
10.1172/jci.insight.91229
10.1002/jor.20649
10.1186/s12974-016-0614-7
10.1007/978-1-4939-3810-0_3
10.1213/01.ane.0000198602.29716.53
10.12740/PP/90648
10.1083/jcb.201201038
10.1017/S1461145709991015
10.1002/jnr.23883
10.1213/ANE.0b013e318215217e
10.1002/glia.23312
10.1152/jn.00839.2018
10.1371/journal.pbio.1000527
10.1111/j.1399-6576.2010.02268.x
10.1016/S0079-6123(08)61124-3
10.3389/fimmu.2017.00902
10.1177/0363546511413375
10.1371/journal.pone.0147198
10.1016/S0140-6736(55)92689-1
10.1093/bioinformatics/btp184
10.1007/s12017-015-8361-y
10.1073/pnas.1614017113
10.1046/j.1399-6576.2003.00238.x
10.1515/revneuro-2016-0031
10.1016/S0149-7634(01)00041-0
10.1097/ALN.0b013e318195b569
10.1097/01.anes.0000296071.19434.1e
10.1155/2018/6215350
10.3389/fnins.2019.00062
10.1155/2016/3271579
ContentType Journal Article
Copyright The Author(s) 2020
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Attribution
Copyright_xml – notice: The Author(s) 2020
– notice: This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Attribution
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
Q9U
7X8
1XC
VOOES
5PM
DOI 10.1038/s41598-020-59639-3
DatabaseName Springer Nature OA/Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
Health & Medical Collection (Alumni Edition)
Medical Database
Science Database
Biological Science Database
Proquest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
CrossRef


Publicly Available Content Database
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: PIMPY
  name: Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
ExternalDocumentID PMC7026159
oai:HAL:inserm-02503658v1
32066806
10_1038_s41598_020_59639_3
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFFHD
AFPKN
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
K9.
PKEHL
PQEST
PQUKI
Q9U
7X8
PUEGO
1XC
VOOES
5PM
ID FETCH-LOGICAL-c577t-f5985d8aef78845212f3698a44addc24b817ee06b7c73300cef2d3097ce4a8e03
IEDL.DBID M2P
ISICitedReferencesCount 10
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000563055400005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2045-2322
IngestDate Tue Nov 04 01:56:46 EST 2025
Sat Nov 29 15:09:42 EST 2025
Wed Oct 01 14:08:39 EDT 2025
Tue Oct 07 07:32:02 EDT 2025
Thu Apr 03 06:59:15 EDT 2025
Tue Nov 18 19:56:06 EST 2025
Sat Nov 29 05:32:11 EST 2025
Fri Feb 21 02:38:48 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Attribution: http://creativecommons.org/licenses/by
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c577t-f5985d8aef78845212f3698a44addc24b817ee06b7c73300cef2d3097ce4a8e03
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
PMCID: PMC7026159
ORCID 0000-0003-0188-2554
0000-0001-8984-643X
0000-0002-6510-1086
OpenAccessLink https://www.proquest.com/docview/2356657903?pq-origsite=%requestingapplication%
PMID 32066806
PQID 2356657903
PQPubID 2041939
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7026159
hal_primary_oai_HAL_inserm_02503658v1
proquest_miscellaneous_2357460064
proquest_journals_2356657903
pubmed_primary_32066806
crossref_citationtrail_10_1038_s41598_020_59639_3
crossref_primary_10_1038_s41598_020_59639_3
springer_journals_10_1038_s41598_020_59639_3
PublicationCentury 2000
PublicationDate 2020-02-17
PublicationDateYYYYMMDD 2020-02-17
PublicationDate_xml – month: 02
  year: 2020
  text: 2020-02-17
  day: 17
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2020
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Cheng (CR45) 2019; 74
Terrando (CR22) 2010; 107
Hutchison, Comper, Mainwaring, Richards (CR40) 2011; 39
Krenk, Rasmussen, Kehlet (CR2) 2010; 54
Terrando (CR12) 2010; 107
Lalonde (CR29) 2002; 26
Pillai (CR46) 2010; 13
CR38
Kumar (CR57) 2017; 28
Niraula, Sheridan, Godbout (CR19) 2017; 42
Forlenza (CR39) 2015; 17
Harry (CR26) 2008; 26
Czyż-Szypenbejl, Mędrzycka-Dąbrowska, Kwiecień-Jaguś, Lewandowska (CR3) 2019; 53
Schindelin (CR34) 2012; 9
Preibisch, Saalfeld, Tomancak (CR33) 2009; 25
Zhao, Lu, Wang, Ransohoff, Zhou (CR42) 2016; 30
Evered, Silbert (CR4) 2018; 127
Xu (CR24) 2014; 4
Parkhurst (CR48) 2014; 155
Setty, Stuart (CR49) 1986; 77
Hughes (CR31) 2004; 28
Boakye (CR53) 2019; 121
Kim (CR17) 2000; 20
Dieni (CR47) 2012; 196
Rizzi (CR50) 2018; 66
Rundshagen (CR5) 2014; 111
Feng (CR21) 2017; 2
Simon, Dupuis, Costentin (CR37) 1994; 61
Taylor, Mehrabani, Liu, Taylor, Cahill (CR52) 2017; 95
Spencer-Segal (CR54) 2011; 31
Fong, Sands, Leung (CR14) 2006; 102
DiStefano (CR55) 1992; 8
Zhang (CR15) 2016; 113
Steinmetz, Christensen, Lund, Lohse, Rasmussen (CR8) 2009; 110
CR16
Hardy (CR28) 2016; 11
Monk (CR1) 2008; 108
Bedford (CR9) 1955; 269
Verdonk (CR32) 2016; 13
Rogers (CR43) 2011; 31
Skvarc (CR13) 2018; 84
Tikka, Fiebich, Goldsteins, Keina (CR51) 2001; 21
Yang (CR25) 2017; 8
Lim (CR36) 2015; 35
Dijkstra, Houx, Jolles (CR7) 1999; 82
Evered, Scott, Silbert, Maruff (CR10) 2011; 112
CR23
Koellhoffer, Mccullough, Ritzel (CR20) 2017; 18
Tremblay, Lowery, Majewska (CR18) 2010; 8
Li (CR41) 2018; 46
Wyrobek (CR44) 2017; 119
Canet (CR11) 2003; 47
Le, Lowe, Kyba (CR27) 2016; 1460
DiStefano, Curtis (CR56) 1994; 103
Bryson, Wyand (CR6) 2006; 53
Leger (CR30) 2013; 8
Salter, Stevens (CR35) 2017; 23
PA Boakye (59639_CR53) 2019; 121
TKY Lim (59639_CR36) 2015; 35
RN Hughes (59639_CR31) 2004; 28
C Rizzi (59639_CR50) 2018; 66
W Li (59639_CR41) 2018; 46
M-È Tremblay (59639_CR18) 2010; 8
J Steinmetz (59639_CR8) 2009; 110
JB Dijkstra (59639_CR7) 1999; 82
R Lalonde (59639_CR29) 2002; 26
S Dieni (59639_CR47) 2012; 196
PS DiStefano (59639_CR55) 1992; 8
59639_CR38
W Zhao (59639_CR42) 2016; 30
A Pillai (59639_CR46) 2010; 13
G Le (59639_CR27) 2016; 1460
J Canet (59639_CR11) 2003; 47
MW Salter (59639_CR35) 2017; 23
K Czyż-Szypenbejl (59639_CR3) 2019; 53
S Preibisch (59639_CR33) 2009; 25
S Yang (59639_CR25) 2017; 8
EC Koellhoffer (59639_CR20) 2017; 18
PD Bedford (59639_CR9) 1955; 269
LE Harry (59639_CR26) 2008; 26
DR Skvarc (59639_CR13) 2018; 84
JL Spencer-Segal (59639_CR54) 2011; 31
L Krenk (59639_CR2) 2010; 54
A Niraula (59639_CR19) 2017; 42
X Feng (59639_CR21) 2017; 2
HK Fong (59639_CR14) 2006; 102
AMW Taylor (59639_CR52) 2017; 95
N Terrando (59639_CR12) 2010; 107
OV Forlenza (59639_CR39) 2015; 17
W Kim (59639_CR17) 2000; 20
59639_CR23
P Simon (59639_CR37) 1994; 61
TG Monk (59639_CR1) 2008; 108
CN Parkhurst (59639_CR48) 2014; 155
LA Evered (59639_CR4) 2018; 127
N Terrando (59639_CR22) 2010; 107
A Kumar (59639_CR57) 2017; 28
BN Setty (59639_CR49) 1986; 77
M Leger (59639_CR30) 2013; 8
GL Bryson (59639_CR6) 2006; 53
T Tikka (59639_CR51) 2001; 21
59639_CR16
L Evered (59639_CR10) 2011; 112
PS DiStefano (59639_CR56) 1994; 103
JT Rogers (59639_CR43) 2011; 31
XQ Cheng (59639_CR45) 2019; 74
I Rundshagen (59639_CR5) 2014; 111
F Verdonk (59639_CR32) 2016; 13
J Wyrobek (59639_CR44) 2017; 119
Z Xu (59639_CR24) 2014; 4
M-D Zhang (59639_CR15) 2016; 113
J Schindelin (59639_CR34) 2012; 9
D Hardy (59639_CR28) 2016; 11
M Hutchison (59639_CR40) 2011; 39
References_xml – volume: 31
  start-page: 16241
  year: 2011
  end-page: 50
  ident: CR43
  article-title: CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3667-11.2011
– volume: 84
  start-page: 116
  year: 2018
  end-page: 133
  ident: CR13
  article-title: Post-Operative Cognitive Dysfunction: An exploration of the inflammatory hypothesis and novel therapies
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2017.11.011
– volume: 119
  start-page: 324
  year: 2017
  end-page: 332
  ident: CR44
  article-title: Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults
  publication-title: Br. J. Anaesth.
  doi: 10.1093/bja/aex103
– volume: 82
  start-page: 867
  year: 1999
  end-page: 74
  ident: CR7
  article-title: Cognition after major surgery in the elderly: test performance and complaints
  publication-title: Br. J. Anaesth.
  doi: 10.1093/bja/82.6.867
– ident: CR16
– volume: 4
  year: 2014
  ident: CR24
  article-title: Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice
  publication-title: Sci. Rep.
  doi: 10.1038/srep03766
– volume: 23
  start-page: 1018
  year: 2017
  end-page: 1027
  ident: CR35
  article-title: Microglia emerge as central players in brain disease
  publication-title: Nat. Med.
  doi: 10.1038/nm.4397
– volume: 35
  start-page: 3346
  year: 2015
  end-page: 59
  ident: CR36
  article-title: Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4040-14.2015
– volume: 107
  start-page: 20518
  year: 2010
  end-page: 22
  ident: CR12
  article-title: Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1014557107
– volume: 8
  start-page: 983
  year: 1992
  end-page: 993
  ident: CR55
  article-title: The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons
  publication-title: Neuron
  doi: 10.1016/0896-6273(92)90213-W
– volume: 18
  start-page: 1
  year: 2017
  end-page: 25
  ident: CR20
  article-title: Old Maids: Aging and Its Impact on Microglia Function
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms18040769
– volume: 111
  start-page: 119
  year: 2014
  end-page: 25
  ident: CR5
  article-title: Postoperative cognitive dysfunction
  publication-title: Dtsch. Arztebl. Int.
– volume: 155
  start-page: 1596
  year: 2014
  end-page: 1609
  ident: CR48
  article-title: Microglia promote learning-dependent synapse formation through BDNF
  publication-title: Cell.
  doi: 10.1016/j.cell.2013.11.030
– volume: 20
  start-page: 6309
  year: 2000
  end-page: 6316
  ident: CR17
  article-title: Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-16-06309.2000
– volume: 42
  start-page: 318
  year: 2017
  end-page: 333
  ident: CR19
  article-title: Microglia Priming with Aging and Stress
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2016.185
– volume: 31
  start-page: 6780
  year: 2011
  end-page: 90
  ident: CR54
  article-title: Distribution of phosphorylated TrkB receptor in the mouse hippocampal formation depends on sex and estrous cycle stage
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0910-11.2011
– volume: 9
  start-page: 676
  year: 2012
  end-page: 682
  ident: CR34
  article-title: Fiji - an Open Source platform for biological image analysis
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2019
– volume: 21
  start-page: 2580
  year: 2001
  end-page: 8
  ident: CR51
  article-title: Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.21-08-02580.2001
– volume: 127
  start-page: 496
  year: 2018
  end-page: 505
  ident: CR4
  article-title: Postoperative Cognitive Dysfunction and Noncardiac Surgery
  publication-title: Anesth. Analg.
  doi: 10.1213/ANE.0000000000003514
– volume: 46
  start-page: 1404
  year: 2018
  end-page: 1413
  ident: CR41
  article-title: High doses of minocycline may induce delayed activation of microglia in aged rats and thus cannot prevent postoperative cognitive dysfunction
  publication-title: J. Int. Med. Res.
  doi: 10.1177/0300060517754032
– volume: 8
  start-page: 2531
  year: 2013
  end-page: 7
  ident: CR30
  article-title: Object recognition test in mice
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.155
– volume: 28
  start-page: 497
  year: 2004
  end-page: 505
  ident: CR31
  article-title: The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2004.06.006
– volume: 77
  start-page: 202
  year: 1986
  end-page: 11
  ident: CR49
  article-title: 15-Hydroxy-5,8,11,13-eicosatetraenoic acid inhibits human vascular cyclooxygenase
  publication-title: Potential role in diabetic vascular disease. J. Clin. Invest.
– volume: 61
  start-page: 59
  year: 1994
  end-page: 64
  ident: CR37
  article-title: Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions
  publication-title: Behav. Brain Res.
  doi: 10.1016/0166-4328(94)90008-6
– volume: 74
  start-page: 741
  year: 2019
  end-page: 750
  ident: CR45
  article-title: A multicentre randomised controlled trial of the effect of intra-operative dexmedetomidine on cognitive decline after surgery
  publication-title: Anaesthesia
  doi: 10.1111/anae.14606
– volume: 30
  start-page: 380
  year: 2016
  end-page: 393
  ident: CR42
  article-title: CX3CR1 deficiency delays acute skeletal muscle injury repair by impairing macrophage functions
  publication-title: FASEB J.
  doi: 10.1096/fj.14-270090
– volume: 53
  start-page: 669
  year: 2006
  end-page: 677
  ident: CR6
  article-title: Evidence-based clinical update: General anesthesia and the risk of delirium and postoperative cognitive dysfunction
  publication-title: Can. J. Anesth.
  doi: 10.1007/BF03021625
– volume: 2
  start-page: e91229
  year: 2017
  ident: CR21
  article-title: Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice
  publication-title: JCI insight
  doi: 10.1172/jci.insight.91229
– volume: 26
  start-page: 1238
  year: 2008
  end-page: 44
  ident: CR26
  article-title: Comparison of the healing of open tibial fractures covered with either muscle or fasciocutaneous tissue in a murine model
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.20649
– volume: 13
  year: 2016
  ident: CR32
  article-title: Phenotypic clustering: a novel method for microglial morphology analysis
  publication-title: J. Neuroinflammation
  doi: 10.1186/s12974-016-0614-7
– volume: 1460
  start-page: 33
  year: 2016
  end-page: 41
  ident: CR27
  article-title: Freeze injury of the tibialis anterior muscle
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-3810-0_3
– volume: 102
  start-page: 1255
  year: 2006
  end-page: 66
  ident: CR14
  article-title: The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review
  publication-title: Anesth. Analg.
  doi: 10.1213/01.ane.0000198602.29716.53
– volume: 53
  start-page: 145
  year: 2019
  end-page: 160
  ident: CR3
  article-title: The Occurrence of Postoperative Cognitive Dysfunction (POCD) - Systematic Review
  publication-title: Psychiatr. Pol.
  doi: 10.12740/PP/90648
– volume: 196
  start-page: 775
  year: 2012
  end-page: 88
  ident: CR47
  article-title: BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201201038
– volume: 13
  start-page: 535
  year: 2010
  end-page: 539
  ident: CR46
  article-title: Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: Correlation with plasma BDNF and psychopathology
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1017/S1461145709991015
– volume: 95
  start-page: 1330
  year: 2017
  end-page: 1335
  ident: CR52
  article-title: Topography of microglial activation in sensory and affect related brain regions in chronic pain
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.23883
– volume: 112
  start-page: 1179
  year: 2011
  end-page: 1185
  ident: CR10
  article-title: Postoperative cognitive dysfunction is independent of type of surgery and anesthetic
  publication-title: Anesth. Analg.
  doi: 10.1213/ANE.0b013e318215217e
– volume: 66
  start-page: 1395
  year: 2018
  end-page: 1416
  ident: CR50
  article-title: NGF steers microglia toward a neuroprotective phenotype
  publication-title: Glia
  doi: 10.1002/glia.23312
– volume: 121
  start-page: 2308
  year: 2019
  end-page: 2322
  ident: CR53
  article-title: Receptor dependence of BDNF actions in superficial dorsal horn: relation to central sensitization and actions of macrophage colony stimulating factor 1
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00839.2018
– volume: 8
  start-page: e1000527
  year: 2010
  ident: CR18
  article-title: Microglial interactions with synapses are modulated by visual experience
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1000527
– volume: 54
  start-page: 951
  year: 2010
  end-page: 6
  ident: CR2
  article-title: New insights into the pathophysiology of postoperative cognitive dysfunction
  publication-title: Acta Anaesthesiol. Scand.
  doi: 10.1111/j.1399-6576.2010.02268.x
– volume: 103
  start-page: 35
  year: 1994
  end-page: 42
  ident: CR56
  article-title: Receptor mediated retrograde axonal transport of neurotrophic factors is increased after peripheral nerve injury
  publication-title: Prog. Brain Res.
  doi: 10.1016/S0079-6123(08)61124-3
– volume: 8
  start-page: 902
  year: 2017
  ident: CR25
  article-title: Anesthesia and Surgery Impair Blood-Brain Barrier and Cognitive Function in Mice
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.00902
– volume: 39
  start-page: 2331
  year: 2011
  end-page: 2337
  ident: CR40
  article-title: The Influence of Musculoskeletal Injury on Cognition Implications for Concussion The Influence of Musculoskeletal Injury on Cognition: implications for concussion research
  publication-title: Am. J. Sports Med.
  doi: 10.1177/0363546511413375
– volume: 107
  start-page: 20518
  year: 2010
  end-page: 20522
  ident: CR22
  article-title: Tumor necrosis factor-a triggers a cytokine cascade yielding postoperative cognitive decline
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1014557107
– ident: CR23
– volume: 11
  start-page: e0147198
  year: 2016
  ident: CR28
  article-title: Comparative Study of Injury Models for Studying Muscle Regeneration in Mice
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0147198
– volume: 269
  start-page: 259
  year: 1955
  end-page: 63
  ident: CR9
  article-title: Adverse cerebral effects of anaesthesia on old people
  publication-title: Lancet (London, England)
  doi: 10.1016/S0140-6736(55)92689-1
– volume: 25
  start-page: 1463
  year: 2009
  end-page: 5
  ident: CR33
  article-title: Globally optimal stitching of tiled 3D microscopic image acquisitions
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp184
– volume: 17
  start-page: 326
  year: 2015
  end-page: 332
  ident: CR39
  article-title: Lower Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor Predicts Progression from Mild Cognitive Impairment to Alzheimer’s Disease
  publication-title: Neuro. Molecular Med.
  doi: 10.1007/s12017-015-8361-y
– volume: 113
  start-page: E6686
  year: 2016
  end-page: E6695
  ident: CR15
  article-title: Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1614017113
– volume: 47
  start-page: 1204
  year: 2003
  end-page: 10
  ident: CR11
  article-title: Cognitive dysfunction after minor surgery in the elderly
  publication-title: Acta Anaesthesiol. Scand.
  doi: 10.1046/j.1399-6576.2003.00238.x
– ident: CR38
– volume: 28
  start-page: 649
  year: 2017
  end-page: 673
  ident: CR57
  article-title: Regulatory role of NGFs in neurocognitive functions
  publication-title: Rev. Neurosci.
  doi: 10.1515/revneuro-2016-0031
– volume: 26
  start-page: 91
  year: 2002
  end-page: 104
  ident: CR29
  article-title: The neurobiological basis of spontaneous alternation
  publication-title: Neuroscience and Biobehavioral Reviews
  doi: 10.1016/S0149-7634(01)00041-0
– volume: 110
  start-page: 548
  year: 2009
  end-page: 555
  ident: CR8
  article-title: Long-term consequences of postoperative cognitive dysfunction
  publication-title: Anesthesiology
  doi: 10.1097/ALN.0b013e318195b569
– volume: 108
  start-page: 18
  year: 2008
  end-page: 30
  ident: CR1
  article-title: Predictors of cognitive dysfunction after major noncardiac surgery
  publication-title: Anesthesiology
  doi: 10.1097/01.anes.0000296071.19434.1e
– volume: 25
  start-page: 1463
  year: 2009
  ident: 59639_CR33
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp184
– volume: 119
  start-page: 324
  year: 2017
  ident: 59639_CR44
  publication-title: Br. J. Anaesth.
  doi: 10.1093/bja/aex103
– volume: 53
  start-page: 669
  year: 2006
  ident: 59639_CR6
  publication-title: Can. J. Anesth.
  doi: 10.1007/BF03021625
– volume: 8
  start-page: 2531
  year: 2013
  ident: 59639_CR30
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.155
– volume: 112
  start-page: 1179
  year: 2011
  ident: 59639_CR10
  publication-title: Anesth. Analg.
  doi: 10.1213/ANE.0b013e318215217e
– volume: 103
  start-page: 35
  year: 1994
  ident: 59639_CR56
  publication-title: Prog. Brain Res.
  doi: 10.1016/S0079-6123(08)61124-3
– volume: 107
  start-page: 20518
  year: 2010
  ident: 59639_CR22
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1014557107
– volume: 13
  start-page: 535
  year: 2010
  ident: 59639_CR46
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1017/S1461145709991015
– ident: 59639_CR16
  doi: 10.1155/2018/6215350
– volume: 18
  start-page: 1
  year: 2017
  ident: 59639_CR20
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms18040769
– volume: 2
  start-page: e91229
  year: 2017
  ident: 59639_CR21
  publication-title: JCI insight
  doi: 10.1172/jci.insight.91229
– ident: 59639_CR38
  doi: 10.3389/fnins.2019.00062
– volume: 54
  start-page: 951
  year: 2010
  ident: 59639_CR2
  publication-title: Acta Anaesthesiol. Scand.
  doi: 10.1111/j.1399-6576.2010.02268.x
– volume: 61
  start-page: 59
  year: 1994
  ident: 59639_CR37
  publication-title: Behav. Brain Res.
  doi: 10.1016/0166-4328(94)90008-6
– volume: 9
  start-page: 676
  year: 2012
  ident: 59639_CR34
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2019
– volume: 127
  start-page: 496
  year: 2018
  ident: 59639_CR4
  publication-title: Anesth. Analg.
  doi: 10.1213/ANE.0000000000003514
– volume: 21
  start-page: 2580
  year: 2001
  ident: 59639_CR51
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.21-08-02580.2001
– volume: 30
  start-page: 380
  year: 2016
  ident: 59639_CR42
  publication-title: FASEB J.
  doi: 10.1096/fj.14-270090
– volume: 74
  start-page: 741
  year: 2019
  ident: 59639_CR45
  publication-title: Anaesthesia
  doi: 10.1111/anae.14606
– volume: 28
  start-page: 649
  year: 2017
  ident: 59639_CR57
  publication-title: Rev. Neurosci.
  doi: 10.1515/revneuro-2016-0031
– volume: 26
  start-page: 91
  year: 2002
  ident: 59639_CR29
  publication-title: Neuroscience and Biobehavioral Reviews
  doi: 10.1016/S0149-7634(01)00041-0
– volume: 23
  start-page: 1018
  year: 2017
  ident: 59639_CR35
  publication-title: Nat. Med.
  doi: 10.1038/nm.4397
– volume: 113
  start-page: E6686
  year: 2016
  ident: 59639_CR15
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1614017113
– volume: 155
  start-page: 1596
  year: 2014
  ident: 59639_CR48
  publication-title: Cell.
  doi: 10.1016/j.cell.2013.11.030
– volume: 82
  start-page: 867
  year: 1999
  ident: 59639_CR7
  publication-title: Br. J. Anaesth.
  doi: 10.1093/bja/82.6.867
– volume: 31
  start-page: 6780
  year: 2011
  ident: 59639_CR54
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0910-11.2011
– volume: 8
  start-page: 983
  year: 1992
  ident: 59639_CR55
  publication-title: Neuron
  doi: 10.1016/0896-6273(92)90213-W
– volume: 42
  start-page: 318
  year: 2017
  ident: 59639_CR19
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2016.185
– volume: 102
  start-page: 1255
  year: 2006
  ident: 59639_CR14
  publication-title: Anesth. Analg.
  doi: 10.1213/01.ane.0000198602.29716.53
– volume: 66
  start-page: 1395
  year: 2018
  ident: 59639_CR50
  publication-title: Glia
  doi: 10.1002/glia.23312
– volume: 26
  start-page: 1238
  year: 2008
  ident: 59639_CR26
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.20649
– volume: 17
  start-page: 326
  year: 2015
  ident: 59639_CR39
  publication-title: Neuro. Molecular Med.
  doi: 10.1007/s12017-015-8361-y
– volume: 111
  start-page: 119
  year: 2014
  ident: 59639_CR5
  publication-title: Dtsch. Arztebl. Int.
– volume: 196
  start-page: 775
  year: 2012
  ident: 59639_CR47
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201201038
– volume: 8
  start-page: 902
  year: 2017
  ident: 59639_CR25
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.00902
– volume: 269
  start-page: 259
  year: 1955
  ident: 59639_CR9
  publication-title: Lancet (London, England)
  doi: 10.1016/S0140-6736(55)92689-1
– volume: 95
  start-page: 1330
  year: 2017
  ident: 59639_CR52
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.23883
– volume: 107
  start-page: 20518
  year: 2010
  ident: 59639_CR12
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1014557107
– volume: 20
  start-page: 6309
  year: 2000
  ident: 59639_CR17
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-16-06309.2000
– volume: 13
  year: 2016
  ident: 59639_CR32
  publication-title: J. Neuroinflammation
  doi: 10.1186/s12974-016-0614-7
– ident: 59639_CR23
  doi: 10.1155/2016/3271579
– volume: 39
  start-page: 2331
  year: 2011
  ident: 59639_CR40
  publication-title: Am. J. Sports Med.
  doi: 10.1177/0363546511413375
– volume: 77
  start-page: 202
  year: 1986
  ident: 59639_CR49
  publication-title: Potential role in diabetic vascular disease. J. Clin. Invest.
– volume: 84
  start-page: 116
  year: 2018
  ident: 59639_CR13
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2017.11.011
– volume: 31
  start-page: 16241
  year: 2011
  ident: 59639_CR43
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3667-11.2011
– volume: 8
  start-page: e1000527
  year: 2010
  ident: 59639_CR18
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1000527
– volume: 53
  start-page: 145
  year: 2019
  ident: 59639_CR3
  publication-title: Psychiatr. Pol.
  doi: 10.12740/PP/90648
– volume: 4
  year: 2014
  ident: 59639_CR24
  publication-title: Sci. Rep.
  doi: 10.1038/srep03766
– volume: 28
  start-page: 497
  year: 2004
  ident: 59639_CR31
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2004.06.006
– volume: 47
  start-page: 1204
  year: 2003
  ident: 59639_CR11
  publication-title: Acta Anaesthesiol. Scand.
  doi: 10.1046/j.1399-6576.2003.00238.x
– volume: 35
  start-page: 3346
  year: 2015
  ident: 59639_CR36
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4040-14.2015
– volume: 108
  start-page: 18
  year: 2008
  ident: 59639_CR1
  publication-title: Anesthesiology
  doi: 10.1097/01.anes.0000296071.19434.1e
– volume: 11
  start-page: e0147198
  year: 2016
  ident: 59639_CR28
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0147198
– volume: 46
  start-page: 1404
  year: 2018
  ident: 59639_CR41
  publication-title: J. Int. Med. Res.
  doi: 10.1177/0300060517754032
– volume: 110
  start-page: 548
  year: 2009
  ident: 59639_CR8
  publication-title: Anesthesiology
  doi: 10.1097/ALN.0b013e318195b569
– volume: 1460
  start-page: 33
  year: 2016
  ident: 59639_CR27
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-3810-0_3
– volume: 121
  start-page: 2308
  year: 2019
  ident: 59639_CR53
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00839.2018
SSID ssj0000529419
Score 2.3476574
Snippet Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to...
SourceID pubmedcentral
hal
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2768
SubjectTerms 14/19
631/378/371
64/110
692/617/375
96/63
Aging - pathology
Animal cognition
Animal models
Animals
Behavioral plasticity
Brain - pathology
Brain - surgery
Brain research
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Cognitive ability
Cognitive science
Critical care
CX3C Chemokine Receptor 1 - genetics
Cytokines - metabolism
Disease Models, Animal
Experiments
Hippocampus - injuries
Hippocampus - pathology
Hippocampus - surgery
Human health and pathology
Humanities and Social Sciences
Humans
Inflammation
Life Sciences
Locomotion
Long term memory
Male
Memory
Mice
Microglia
Microglia - pathology
Morphology
multidisciplinary
Muscle, Skeletal - injuries
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Muscle, Skeletal - surgery
Nerve growth factor
Nerve Growth Factor - metabolism
Pathophysiology
Postoperative Cognitive Complications - etiology
Postoperative Cognitive Complications - metabolism
Postoperative Cognitive Complications - pathology
Postoperative Complications - etiology
Postoperative Complications - metabolism
Postoperative Complications - pathology
Regeneration
Science
Science (multidisciplinary)
Skeletal muscle
Surgery
Synaptic plasticity
Young adults
Title Muscle Injury Induces Postoperative Cognitive Dysfunction
URI https://link.springer.com/article/10.1038/s41598-020-59639-3
https://www.ncbi.nlm.nih.gov/pubmed/32066806
https://www.proquest.com/docview/2356657903
https://www.proquest.com/docview/2357460064
https://inserm.hal.science/inserm-02503658
https://pubmed.ncbi.nlm.nih.gov/PMC7026159
Volume 10
WOSCitedRecordID wos000563055400005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: DOA
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: M~E
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: M7P
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: 7X7
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: BENPR
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: PIMPY
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Science Database (ProQuest)
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: M2P
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/sciencejournals
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED_RFSRe-B4ERhUkeIJoSezknCc0xqZNWqsIgVSerNRxtCJIy9JO2n_PnZN0KhN74cUPsaPEvvPd-e58P4C3FmWFVYVBHBUYcPkWkoNFEkgjUrSlIZXmUEvOcDJR02mWdw63pkur7GWiE9TlwrCPfD8WCQcJslB8XP4OGDWKo6sdhMYAhmTZRJzSNY7zjY-Fo1gyyrq7MqFQ-w3pK75TRmemhFgvC8SWPhqcczbkTVPzZsbkX2FTp42OH_7vPB7Bg84O9Q9axnkMd2z9BO61yJRXTyEbrxt67p_WP2jRfQb4IIHiM7TvYmnbauH-YZ965H--alhBMpGfwbfjo6-HJ0GHshCYBHEVVLQgSakKW9FpWPJV3kqkmSqkJNFnYjlTEVobpjM0KEQYGlvFpQgzNFYWyoZiF3bqRW1fgG-LxFpVzZQoURpSgyiiKJMyLNOCoz0eRP1aa9OVIGckjJ_ahcKF0i19NNFHO_po4cH7zTvLtgDHraPfEQk3A7l29snBmZ7XtJ9_abb3BJlcl5EHez11dLdpG31NGg_ebLppu3EMpajtYu3GoEzZkPPgecsTm68JLo2vwtQD3OKWrd_Z7qnn566kN_JROMk8-NDz1fVv_Xu2L2-fxSu4HzOnM3wN7sHO6mJtX8Ndc7maNxcjGOAUXatGMPx0NMm_jJxHYuQ2EbdI7TA_Heff_wC4ACBZ
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB61BQQX3o9AgSDRE42axE7GPiBUtVS76nbVQ5F6M1nHURdBdml2i_ZP8RuZyWOrpaK3HrgmTmLHn-fhGc8H8N6hLLAoMIijDAMu30JyMEsCaUWKLrek0mrWkgEOh-r0VB-vwe_uLAynVXYysRbU-cTyHvlOLBIOEuhQfJr-DJg1iqOrHYVGA4tDt_hFLlv1sb9P87sVxwefT_Z6QcsqENgEcRYUiVZJrjJXkPcn-ehqIVKtMilpqdtYjlSEzoXpCC2Ssx9aV8S5CDVaJzPlQkHvXYdbkiuLcapgfLzc0-GomYx0ezYnFGqnIv3IZ9jIR0sI6joQK_pv_YyzL6-atlczNP8K09ba7-DB__bfHsL91s72d5uF8QjWXPkY7jTMm4snoI_mFV33--U3ApXPBCYkMH2mLp5MXVMN3d_rUqv8_UXFBgCD-Cl8uZF-P4ONclK6F-C7LHFOFSMlcpSW1DyKKNKEhDzNOJrlQdTNrbFtiXVm-vhu6lC_UKbBgyE8mBoPRnjwYfnMtCkwcm3rLYLMsiHXBu_tDsy4JHn1w7A9K8ikvIg82OzQYFqhVJlLKHjwbnmbxAnHiLLSTeZ1G5QpG6oePG8wuPya4NL_Kkw9wBV0rnRn9U45PqtLliO7-on2YLvD8WW3_j3al9eP4i3c7Z0cDcygPzx8BfdiXmVM1YObsDE7n7vXcNtezMbV-Zt6mfrw9abx_QfLVnYz
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3Nb9MwFH_aOkBc-GYEBgSJnSBqEjuxfUBoWqlWrat6AGmcTOo4WhGk3dJu6r-2v4738jWVid124Jo4iR3_3of9nt8P4L0VPBNZJrwwSIRH5VtQDyaRxw2LhU0NmrSStWQoRiN5fKzGG3DZnIWhtMpGJ5aKOp0Z2iPvhiyiIIHyWTer0yLGvf7n-alHDFIUaW3oNCqIHNrVBS7fik-DHs71bhj2v3zdP_BqhgHPREIsvCxSMkplYjNcCXI6xpqxWMmEcxR7E_KJDIS1fjwRRuDC3zc2C1PmK2EsT6T1Gb53E7bQJedhB7bGg6Px93aHh2JoPFD1SR2fyW6B1pJOtOGKLULgK4-tWcPNE8rFvO7oXs_X_CtoW9rC_sP_-S8-gge1B-7uVSLzGDZs_gTuVpycq6egjpYFXncH-U-Em0vUJqhKXSI1ns1tVSfd3W-SrtzeqiDXgOD9DL7dSr-fQyef5fYFuDaJrJXZRLJUcIMOgGBBoDj30zihOJcDQTPP2tTF14kD5JcukwCY1BU2NGJDl9jQzIEP7TPzqvTIja13ET5tQ6oafrA31NMcNdlvTZ4uQ2fzPHBgp0GGrtVVoa9g4cC79jYqGooeJbmdLcs2gsfkwjqwXeGx_RojUgDpxw6INaSudWf9Tj49KYuZC9oEiJQDHxtMX3Xr36N9efMo3sI9hLUeDkaHr-B-SAJHHD5iBzqLs6V9DXfM-WJanL2pZdaFH7cN8D-T34B8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Muscle+Injury+Induces+Postoperative+Cognitive+Dysfunction&rft.jtitle=Scientific+reports&rft.au=Gu%C3%A9niot%2C+Lorna&rft.au=Lepere%2C+Victoria&rft.au=De+Medeiros%2C+Gabriela+Ferreira&rft.au=Danckaert%2C+Anne&rft.date=2020-02-17&rft.eissn=2045-2322&rft.volume=10&rft.issue=1&rft.spage=2768&rft_id=info:doi/10.1038%2Fs41598-020-59639-3&rft_id=info%3Apmid%2F32066806&rft.externalDocID=32066806
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon