A zebrafish functional genomics model to investigate the role of human A20 variants in vivo

Germline loss-of-function variation in TNFAIP3 , encoding A20, has been implicated in a wide variety of autoinflammatory and autoimmune conditions, with acquired somatic missense mutations linked to cancer progression. Furthermore, human sequence data reveals that the A20 locus contains ~ 400 non-sy...

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Veröffentlicht in:	Scientific reports Jg. 10; H. 1; S. 19085
Hauptverfasser:	Cultrone, Daniele, Zammit, Nathan W., Self, Eleanor, Postert, Benno, Han, Jeremy Z. R., Bailey, Jacqueline, Warren, Joanna, Croucher, David R., Kikuchi, Kazu, Bogdanovic, Ozren, Chtanova, Tatyana, Hesselson, Daniel, Grey, Shane T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 05.11.2020 Nature Publishing Group
Schlagworte:	631/181 631/208 631/250 631/337 692/4017 692/699 Alanine Amino Acid Substitution Animals Animals, Genetically Modified Autoimmune diseases Autoimmune Diseases - etiology Autoimmune Diseases - genetics Conserved Sequence Danio rerio Evolution, Molecular Genetic diversity Genetic variance Genetic Variation Genomics Humanities and Social Sciences Humans Immune response Inflammation - etiology Inflammation - genetics Lethality Macrophages - immunology Macrophages - metabolism Missense mutation Models, Animal Models, Genetic multidisciplinary Mutation Mutation, Missense NF-kappa B - metabolism Phosphorylation Recombinant Proteins - genetics Recombinant Proteins - metabolism Science Science (multidisciplinary) Tumor Necrosis Factor alpha-Induced Protein 3 - deficiency Tumor Necrosis Factor alpha-Induced Protein 3 - genetics Tumor Necrosis Factor alpha-Induced Protein 3 - physiology Zebrafish Zebrafish - genetics Zebrafish - physiology Zebrafish Proteins - deficiency Zebrafish Proteins - genetics Zebrafish Proteins - physiology
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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