Sleep Timing, Stability, and BP in the Sueño Ancillary Study of the Hispanic Community Health Study/Study of Latinos

Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk. In this multicenter, cross-sectional...

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Published in:	Chest Vol. 155; no. 1; p. 60
Main Authors:	Abbott, Sabra M, Weng, Jia, Reid, Kathryn J, Daviglus, Martha L, Gallo, Linda C, Loredo, Jose S, Nyenhuis, Sharmilee M, Ramos, Alberto R, Shah, Neomi A, Sotres-Alvarez, Daniela, Patel, Sanjay R, Zee, Phyllis C
Format:	Journal Article
Language:	English
Published:	United States 01.01.2019
Subjects:	Actigraphy Adolescent Adult Blood Pressure - physiology Circadian Rhythm - physiology Cross-Sectional Studies Female Follow-Up Studies Hispanic or Latino Humans Incidence Information Systems Male Middle Aged Prevalence Public Health Retrospective Studies Self Report Sleep - physiology Sleep Initiation and Maintenance Disorders - ethnology Sleep Initiation and Maintenance Disorders - physiopathology Time Factors United States - epidemiology Young Adult United States sleep cardiovascular diseases hypertension circadian rhythm
ISSN:	1931-3543, 1931-3543
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Abstract	Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk. In this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status. Each 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P < .05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P < .05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P < .05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P < .01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P < .01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance. These results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP.
AbstractList	Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk.BACKGROUNDTiming and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk.In this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status.METHODSIn this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status.Each 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P < .05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P < .05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P < .05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P < .01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P < .01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance.RESULTSEach 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P < .05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P < .05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P < .05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P < .01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P < .01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance.These results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP.CONCLUSIONSThese results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP. Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk. In this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status. Each 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P < .05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P < .05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P < .05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P < .01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P < .01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance. These results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP.
Author	Gallo, Linda C Loredo, Jose S Weng, Jia Nyenhuis, Sharmilee M Reid, Kathryn J Daviglus, Martha L Ramos, Alberto R Sotres-Alvarez, Daniela Zee, Phyllis C Abbott, Sabra M Patel, Sanjay R Shah, Neomi A
Author_xml	– sequence: 1 givenname: Sabra M surname: Abbott fullname: Abbott, Sabra M email: sabra.abbott@northwestern.edu organization: Department of Neurology, Northwestern University, Chicago, IL. Electronic address: sabra.abbott@northwestern.edu – sequence: 2 givenname: Jia surname: Weng fullname: Weng, Jia organization: Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA – sequence: 3 givenname: Kathryn J surname: Reid fullname: Reid, Kathryn J organization: Department of Neurology, Northwestern University, Chicago, IL – sequence: 4 givenname: Martha L surname: Daviglus fullname: Daviglus, Martha L organization: Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL – sequence: 5 givenname: Linda C surname: Gallo fullname: Gallo, Linda C organization: Department of Psychology, San Diego State University, San Diego, CA – sequence: 6 givenname: Jose S surname: Loredo fullname: Loredo, Jose S organization: Division of Pulmonary and Critical Care Medicine, University of California San Diego, San Diego, CA – sequence: 7 givenname: Sharmilee M surname: Nyenhuis fullname: Nyenhuis, Sharmilee M organization: Department of Medicine, University of Illinois at Chicago, Chicago, IL – sequence: 8 givenname: Alberto R surname: Ramos fullname: Ramos, Alberto R organization: Department of Neurology, University of Miami, Miami, FL – sequence: 9 givenname: Neomi A surname: Shah fullname: Shah, Neomi A organization: Division of Pulmonary, Critical Care and Sleep, Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 10 givenname: Daniela surname: Sotres-Alvarez fullname: Sotres-Alvarez, Daniela organization: Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC – sequence: 11 givenname: Sanjay R surname: Patel fullname: Patel, Sanjay R organization: Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA – sequence: 12 givenname: Phyllis C surname: Zee fullname: Zee, Phyllis C organization: Department of Neurology, Northwestern University, Chicago, IL
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SubjectTerms	Actigraphy Adolescent Adult Blood Pressure - physiology Circadian Rhythm - physiology Cross-Sectional Studies Female Follow-Up Studies Hispanic or Latino Humans Incidence Information Systems Male Middle Aged Prevalence Public Health Retrospective Studies Self Report Sleep - physiology Sleep Initiation and Maintenance Disorders - ethnology Sleep Initiation and Maintenance Disorders - physiopathology Time Factors United States - epidemiology Young Adult
Title	Sleep Timing, Stability, and BP in the Sueño Ancillary Study of the Hispanic Community Health Study/Study of Latinos
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