Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis

Obesity has been linked to increased mortality in several cancer types; however, the relation between obesity and survival outcomes in metastatic melanoma is unknown. The aim of this study was to examine the association between body-mass index (BMI) and progression-free survival or overall survival...

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Published in:	The lancet oncology Vol. 19; no. 3; pp. 310 - 322
Main Authors:	McQuade, Jennifer L, Daniel, Carrie R, Hess, Kenneth R, Mak, Carmen, Wang, Daniel Y, Rai, Rajat R, Park, John J, Haydu, Lauren E, Spencer, Christine, Wongchenko, Matthew, Lane, Stephen, Lee, Dung-Yang, Kaper, Mathilde, McKean, Meredith, Beckermann, Kathryn E, Rubinstein, Samuel M, Rooney, Isabelle, Musib, Luna, Budha, Nageshwar, Hsu, Jessie, Nowicki, Theodore S, Avila, Alexandre, Haas, Tomas, Puligandla, Maneka, Lee, Sandra, Fang, Shenying, Wargo, Jennifer A, Gershenwald, Jeffrey E, Lee, Jeffrey E, Hwu, Patrick, Chapman, Paul B, Sosman, Jeffrey A, Schadendorf, Dirk, Grob, Jean-Jacques, Flaherty, Keith T, Walker, Dana, Yan, Yibing, McKenna, Edward, Legos, Jeffrey J, Carlino, Matteo S, Ribas, Antoni, Kirkwood, John M, Long, Georgina V, Johnson, Douglas B, Menzies, Alexander M, Davies, Michael A
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.03.2018 Elsevier Limited
Subjects:	Adipocytes Adolescent Adult Aged Aged, 80 and over Antineoplastic Agents, Immunological - adverse effects Antineoplastic Agents, Immunological - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Body Mass Index Body weight Cancer Cancer therapies Chemotherapy Clinical outcomes Clinical trials Dacarbazine Female Gender differences Hematology, Oncology, and Palliative Medicine Humans Immunotherapy Male Medical prognosis Medical research Melanoma Melanoma - drug therapy Melanoma - immunology Melanoma - mortality Melanoma - secondary Metastases Metastasis Middle Aged Molecular Targeted Therapy - adverse effects Molecular Targeted Therapy - mortality Mutation Obesity Obesity - diagnosis Obesity - epidemiology Obesity - mortality Overweight Patients Pembrolizumab Progression-Free Survival Protective Factors Randomized Controlled Trials as Topic Retrospective Studies Risk Assessment Risk Factors Skin Neoplasms - drug therapy Skin Neoplasms - immunology Skin Neoplasms - mortality Skin Neoplasms - pathology Studies Survival Time Factors Treatment Outcome Underweight Young Adult United States > US
ISSN:	1470-2045, 1474-5488, 1474-5488
Online Access:	Get full text
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