Increased Severity of Ulcerative Colitis in the Terminal Phase of the Metabolic Syndrome
Ulcerative colitis is chronic immune-mediated disorder that affects primarily colonic mucosa. The metabolic syndrome has increasing global prevalence with a significant impact on biology of chronic diseases, such as ulcerative colitis. Today it is known that the metabolic syndrome attenuates severit...
Uloženo v:
| Vydáno v: | Tohoku journal of experimental medicine Ročník 254; číslo 3; s. 171 |
|---|---|
| Hlavní autoři: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Japan
2021
|
| Témata: | |
| ISSN: | 1349-3329, 1349-3329 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Ulcerative colitis is chronic immune-mediated disorder that affects primarily colonic mucosa. The metabolic syndrome has increasing global prevalence with a significant impact on biology of chronic diseases, such as ulcerative colitis. Today it is known that the metabolic syndrome attenuates severity of ulcerative colitis. Still, there is no evidence that different stages of metabolic syndrome alter the course of the ulcerative colitis. The aim of this study was to dissect out how progression of the metabolic syndrome impacted the biology of ulcerative colitis and severity of clinical presentation. Seventy-two patients (41 men and 31 women, 22-81 years old) were enrolled in this observational cross-sectional study. Concentrations of pro- and anti-inflammatory cytokines in serum and feces samples were measured and phenotype of colon infiltrating cells was analyzed. Patients in the terminal phase of the metabolic syndrome have clinically and pathohistologically more severe form of ulcerative colitis, which is followed by decreased concentrations of systemic galectin-1, increased values of systemic pro-inflammatory mediators and increased influx of lymphocytes in affected colon tissue. Our data suggest that reduced concentrations of galectin-1 and predomination of the pro-inflammatory mediators in patients with terminal stage of the metabolic syndrome enhance local chronic inflammatory response and subsequent tissue damage, and together point on important role of galectin-1 in immune response in ulcerative colitis patients with the metabolic syndrome. |
|---|---|
| AbstractList | Ulcerative colitis is chronic immune-mediated disorder that affects primarily colonic mucosa. The metabolic syndrome has increasing global prevalence with a significant impact on biology of chronic diseases, such as ulcerative colitis. Today it is known that the metabolic syndrome attenuates severity of ulcerative colitis. Still, there is no evidence that different stages of metabolic syndrome alter the course of the ulcerative colitis. The aim of this study was to dissect out how progression of the metabolic syndrome impacted the biology of ulcerative colitis and severity of clinical presentation. Seventy-two patients (41 men and 31 women, 22-81 years old) were enrolled in this observational cross-sectional study. Concentrations of pro- and anti-inflammatory cytokines in serum and feces samples were measured and phenotype of colon infiltrating cells was analyzed. Patients in the terminal phase of the metabolic syndrome have clinically and pathohistologically more severe form of ulcerative colitis, which is followed by decreased concentrations of systemic galectin-1, increased values of systemic pro-inflammatory mediators and increased influx of lymphocytes in affected colon tissue. Our data suggest that reduced concentrations of galectin-1 and predomination of the pro-inflammatory mediators in patients with terminal stage of the metabolic syndrome enhance local chronic inflammatory response and subsequent tissue damage, and together point on important role of galectin-1 in immune response in ulcerative colitis patients with the metabolic syndrome. Ulcerative colitis is chronic immune-mediated disorder that affects primarily colonic mucosa. The metabolic syndrome has increasing global prevalence with a significant impact on biology of chronic diseases, such as ulcerative colitis. Today it is known that the metabolic syndrome attenuates severity of ulcerative colitis. Still, there is no evidence that different stages of metabolic syndrome alter the course of the ulcerative colitis. The aim of this study was to dissect out how progression of the metabolic syndrome impacted the biology of ulcerative colitis and severity of clinical presentation. Seventy-two patients (41 men and 31 women, 22-81 years old) were enrolled in this observational cross-sectional study. Concentrations of pro- and anti-inflammatory cytokines in serum and feces samples were measured and phenotype of colon infiltrating cells was analyzed. Patients in the terminal phase of the metabolic syndrome have clinically and pathohistologically more severe form of ulcerative colitis, which is followed by decreased concentrations of systemic galectin-1, increased values of systemic pro-inflammatory mediators and increased influx of lymphocytes in affected colon tissue. Our data suggest that reduced concentrations of galectin-1 and predomination of the pro-inflammatory mediators in patients with terminal stage of the metabolic syndrome enhance local chronic inflammatory response and subsequent tissue damage, and together point on important role of galectin-1 in immune response in ulcerative colitis patients with the metabolic syndrome.Ulcerative colitis is chronic immune-mediated disorder that affects primarily colonic mucosa. The metabolic syndrome has increasing global prevalence with a significant impact on biology of chronic diseases, such as ulcerative colitis. Today it is known that the metabolic syndrome attenuates severity of ulcerative colitis. Still, there is no evidence that different stages of metabolic syndrome alter the course of the ulcerative colitis. The aim of this study was to dissect out how progression of the metabolic syndrome impacted the biology of ulcerative colitis and severity of clinical presentation. Seventy-two patients (41 men and 31 women, 22-81 years old) were enrolled in this observational cross-sectional study. Concentrations of pro- and anti-inflammatory cytokines in serum and feces samples were measured and phenotype of colon infiltrating cells was analyzed. Patients in the terminal phase of the metabolic syndrome have clinically and pathohistologically more severe form of ulcerative colitis, which is followed by decreased concentrations of systemic galectin-1, increased values of systemic pro-inflammatory mediators and increased influx of lymphocytes in affected colon tissue. Our data suggest that reduced concentrations of galectin-1 and predomination of the pro-inflammatory mediators in patients with terminal stage of the metabolic syndrome enhance local chronic inflammatory response and subsequent tissue damage, and together point on important role of galectin-1 in immune response in ulcerative colitis patients with the metabolic syndrome. |
| Author | Jovanovic, Marina Milun Maric, Veljko Jovo Zdravkovic, Natasa Dragan Gajovic, Nevena Miroslav Arsenijevic, Nebojsa Nikola Djukic, Aleksandar Ljubodrag Jurisevic, Milena Milenko Jocic, Miodrag Vukasin Jovanovic, Ivan Petar Jovanovic, Milan Milorad |
| Author_xml | – sequence: 1 givenname: Marina Milun surname: Jovanovic fullname: Jovanovic, Marina Milun organization: Department of Internal medicine, Faculty of Medical Sciences, University of Kragujevac – sequence: 2 givenname: Milena Milenko surname: Jurisevic fullname: Jurisevic, Milena Milenko organization: Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac – sequence: 3 givenname: Nevena Miroslav surname: Gajovic fullname: Gajovic, Nevena Miroslav organization: Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac – sequence: 4 givenname: Nebojsa Nikola surname: Arsenijevic fullname: Arsenijevic, Nebojsa Nikola organization: Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac – sequence: 5 givenname: Miodrag Vukasin surname: Jocic fullname: Jocic, Miodrag Vukasin organization: Institute for Transfusiology and Haemobiology, Military Medical Academy – sequence: 6 givenname: Ivan Petar surname: Jovanovic fullname: Jovanovic, Ivan Petar organization: Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac – sequence: 7 givenname: Natasa Dragan surname: Zdravkovic fullname: Zdravkovic, Natasa Dragan organization: Department of Internal medicine, Faculty of Medical Sciences, University of Kragujevac – sequence: 8 givenname: Aleksandar Ljubodrag surname: Djukic fullname: Djukic, Aleksandar Ljubodrag organization: Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac – sequence: 9 givenname: Veljko Jovo surname: Maric fullname: Maric, Veljko Jovo organization: Department of Surgery, Faculty of Medicine Foca, University of East Sarajevo – sequence: 10 givenname: Milan Milorad surname: Jovanovic fullname: Jovanovic, Milan Milorad organization: Department of Abdominal surgery, Military Medical Academy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34248084$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkM1Lw0AQxRep2A-9eZY9ekndr-wmRylWCxWFtuAtTJIJ3ZKPurst9L83xQqeZhh-b3jvjcmg7Vok5J6zKdeCPYUdNlMRqyk3_IqMuFRpJKVIB__2IRl7v2NMKmb0DRlKJVTCEjUiX4u2cAgeS7rCIzobTrSr6KYu0EGwR6SzrrbBempbGrZI1-ga20JNP7e96syer-8YIO_Bgq5Obem6Bm_JdQW1x7vLnJDN_GU9e4uWH6-L2fMyKmJjQoSiwgohByUZB0ygKjiTmApApnWq44rFWsi8MCZOcgFGmN66RgBRGlQgJuTx9-_edd8H9CFrrC-wrqHF7uAzEcdM97nTpEcfLughb7DM9s424E7ZXxviB4akY1I |
| CitedBy_id | crossref_primary_10_3390_metabo12100930 crossref_primary_10_3748_wjg_v31_i25_107260 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1620/tjem.254.171 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1349-3329 |
| ExternalDocumentID | 34248084 |
| Genre | Journal Article Observational Study |
| GroupedDBID | --- -~X .55 .GJ 123 29Q 2WC 36B 3O- 53G 5RE 7.U ABCQX ACGFO ADBBV AEGXH AENEX AIAGR ALMA_UNASSIGNED_HOLDINGS BAWUL CGR CS3 CUY CVF DIK DU5 E3Z EBD ECM EIF EMB EMOBN F5P GX1 JSF JSH KQ8 L7B MK0 M~E NPM OK1 P2P RJT RNS RZJ SV3 TKC TR2 W2D WH7 X7J X7M XSB ZGI ZXP 7X8 OVT |
| ID | FETCH-LOGICAL-c577t-e2fefeaba4301ae8afc103e92ae066965f05623bc7758b2a7272486eaa2d7e4a2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 4 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000693259900004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1349-3329 |
| IngestDate | Wed Oct 01 13:57:46 EDT 2025 Thu Jan 02 22:56:43 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | ulcerative colitis immune response disease severity metabolic syndrome progression |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c577t-e2fefeaba4301ae8afc103e92ae066965f05623bc7758b2a7272486eaa2d7e4a2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/tjem/254/3/254_171/_pdf |
| PMID | 34248084 |
| PQID | 2550634098 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2550634098 pubmed_primary_34248084 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-00-00 |
| PublicationDateYYYYMMDD | 2021-01-01 |
| PublicationDate_xml | – year: 2021 text: 2021-00-00 |
| PublicationDecade | 2020 |
| PublicationPlace | Japan |
| PublicationPlace_xml | – name: Japan |
| PublicationTitle | Tohoku journal of experimental medicine |
| PublicationTitleAlternate | Tohoku J Exp Med |
| PublicationYear | 2021 |
| SSID | ssj0034076 |
| Score | 2.2648485 |
| Snippet | Ulcerative colitis is chronic immune-mediated disorder that affects primarily colonic mucosa. The metabolic syndrome has increasing global prevalence with a... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 171 |
| SubjectTerms | Adult Aged Aged, 80 and over Anti-Inflammatory Agents - therapeutic use Colitis, Ulcerative - drug therapy Colon Female Humans Intestinal Mucosa Male Metabolic Syndrome - complications Middle Aged Young Adult |
| Title | Increased Severity of Ulcerative Colitis in the Terminal Phase of the Metabolic Syndrome |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34248084 https://www.proquest.com/docview/2550634098 |
| Volume | 254 |
| WOSCitedRecordID | wos000693259900004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LSwMxEA5qRbz4ftQXEbym3d2k-ziJFIuXlkJb2FvJY4KVultt9fc72U31JAhe9pBN2GX4Mvkm8zFDyF1sNMLWSBbyMGZC8oClqTJONI6nrdJBaGzVbCIZDNI8z4b-wm3pZZVrn1g5alNqd0feRuqLpylGI-n94o25rlEuu-pbaGySBkcq41Cd5N9ZBJxdNZdzFfgY51Hmhe9xFLRXL_DawuCoFSbh7-SyOmR6-__9vQOy5-klfajxcEg2oDgiO32fQD8mOfoDJ0MHQ0eAKEYOTktLJ3MNdQlw2q0EcUs6KyhyQzquxTJzOnzGVW6uG-3DCsEzn2k68hUPTsik9zjuPjHfXIHpTpKsGEQWLEglBW5xCam0Ogw4ZJEEZCFZ3LEVNVI6wYhCRdIlbEUag5SRSUDI6JRsFWUB54Rqhe8sx8BIKNFRRrkCPtxqC5mxiosmuV3bbIrgdRkJWUD5sZz-WK1JzmrDTxd1lY0pF_i9IBUXf1h9SXYjpzWprkauSMPi1oVrsq0_0WDvNxUq8DkY9r8AwvXCfg |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Increased+Severity+of+Ulcerative+Colitis+in+the+Terminal+Phase+of+the+Metabolic+Syndrome&rft.jtitle=Tohoku+journal+of+experimental+medicine&rft.au=Jovanovic%2C+Marina+Milun&rft.au=Jurisevic%2C+Milena+Milenko&rft.au=Gajovic%2C+Nevena+Miroslav&rft.au=Arsenijevic%2C+Nebojsa+Nikola&rft.date=2021-01-01&rft.eissn=1349-3329&rft.volume=254&rft.issue=3&rft.spage=171&rft_id=info:doi/10.1620%2Ftjem.254.171&rft_id=info%3Apmid%2F34248084&rft_id=info%3Apmid%2F34248084&rft.externalDocID=34248084 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1349-3329&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1349-3329&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1349-3329&client=summon |